iiiiiiiiii A knack for Lipid, membrane and curiosity driven biology iiiiiiiiiiii
!!!!!!!!! PhD researcher👨🔬| @HolthuisL 🔬|Osnabrück University !!!!!!!!!!!
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics#neuroscience#BrainAtlas
The Lipid Brain Atlas is out now! If you think lipids are boring and membranes are all
the same, prepare to be surprised. Led by Luca Fusar Bassini with Gioele La Manno's lab, we mapped membrane lipids in the mouse brain at high resolution.
https://t.co/q3AeqGsIS1
In @eLife: Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes https://t.co/jglEwm4l3v
Finally!!
It was just plain fun working with @SakshiShambhav1 and @SudiptaCCMB. Congratulations to all involved. 🧪✨🔬
If you’re looking to explore lipid cell heterogeneity and dynamics at single-cell level from a fresh perspective, we encourage you to check out this review on single-cell lipid biology!!! @tynitaa@Asaro_Anto@Gio_Dangel0@TrendsCellBio
https://t.co/Ub9IudxSn8
The opportunity to present my ongoing work (thanks to @HolthuisL) was a pleasure at this beautiful meeting @EMBO ER 2024 in Barga,Italy!
Great talks, terrific discussions, good food, & lots of open questions fenced this well organized dedicated meeting!
🥂
📢 I am so incredibly happy and proud about this one!
🔟+ years in the making, 2,5 years since first submission, 1⃣ year since we posted it @biorxivpreprint, it finally found it’s home @NatureCellBio!
Open access 👇
https://t.co/IWJTxkvmIv
Detailed 🧵down below ⏬
Since long time we tried to achieve “permanent” labelling of plasma membranes. Now it become possible with MemGraft probes, which exploit a new principle of lipid-directed covalent fluorescent labeling of membrane proteins. The MemGraft probes are compatible with fixation, permeabilization, trypsinization, presence of serum in the medium and enable long-term cell imaging, co-culture of cells and their imaging in multiple colors, cell barcoding and cell manipulation. Congrats and thanks to co-authors: Nathan Aknine @n_aknine & Remi Pelletier. @unistra@CNRS@CNRS_Alsace@LBP_Illkirch
Just out in biorXiv:
https://t.co/tKxnUhvFxT
Hello everyone, excited to share our preprint: https://t.co/DoThdFBDLT
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Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate? Lets chat!
Awesome paper by @KayTrue and co answering the age old questions: how many lipids do you need (to form liquid domains)? Answer is only 2 but with interesting caveats!
https://t.co/zqnJg57jN7
We are thrilled to share a truly exciting discovery by cryo electron tomography: the “hemifusome”- a new cellular organelle complex containing a hemifusion diaphragm! Tavakoli et al.
https://t.co/YPio7TscYJ
@amirrasoultav, @HuShiqiong and @Becharakachar
Tweetorial below (1/8)
We’ve worked out how the molecular machines that create acidic compartments can recruit autophagy (self-eating) machinery when they can’t maintain a pH gradient. We are really pleased with this discovery, out in @MolecularCell https://t.co/XOFj4lJ2I7. 1/16
Indeed a historic and very very special moment for India.
Congratulate #IndianHockey Team on winning consecutive bronze medals in #Olympics after so many decades. Indian team’s historic medal at #ParisOlympics2024 has swelled every Indian’s heart in pride. It is also a deeply emotional moment for me personally. May this bring back the halcyon days for hockey, bringing more and more laurels for the country. Best wishes.
Today in @ScienceMagazine we report how lipids specialize for life under the crushing pressures of the deep sea and what this means more broadly for the composition of cell membranes (1/n) https://t.co/AwHsqs6TkZ
Advanced cryo-EM approaches reveal surprising insights into the molecular structure that allows nascent proteins to be inserted into the membrane of the endoplasmic reticulum. https://t.co/1anZpYvJRi