Chris Myers 💻🧬🧪 ☕ ℏ⁻³/N!∬exp(-βĤ) d𝓅 d𝓺

Professor Physics/Chemical Biophysics 💻🧬☕ 🌇 @fordhamnyc
🎓: @bcmhouston ⚕ @riceuniversity🦉 Formerly: @NYUniversity 🗽
@UmBiophys〽@UTMBhealth

[Chris Myers 💻🧬🧪 ☕ ℏ⁻³/N!∬exp(-βĤ) d𝓅 d𝓺 @bayouphysicist]

This is a great analogy, @ylecun!

[ANRF-National cryo-EM Facility @IITK @GpcrLab3434]

A structure of CXCR4 in complex with a de-novo designed miniprotein blocker determined at our @ANRFIndia facility @IITKanpur is published in @Nature! Spearheaded by the lab of Prof. David Baker (Nobel Prize, 2024) @UWproteindesign, it also involves @arshukla and team @IITKanpur.

[Eric Volkmann @e_volkmann]

Introducing gyaradax 🐉: A JAX solver for local flux-tube gyrokinetics with custom CUDA kernels for acceleration.

This entire code was vibecoded by @ggalletti_ and me in a month.

Validated against GKW (CPU-only Fortran code) with 10x speedups. Details and code in the replies.

[Jun Liu Lab @JunLiuLab]

Congratulations to @JunLiuLab @YaleMicroPath researcher @guowangbiao for receiving the poster award at the 11th Annual @Yale Biophysics and Structural Biology Symposium!

[NatureStructMolBiol @NatureSMB]

New online! Atomic models of the Toxoplasma cell invasion machinery https://t.co/k2lgsir5Q4

[Biophysics from Cambridge University Press @Biophysics_CUP]

8/8
@MishaKudryashev puts it simply:
CryoET offers biological realism — but demands we evolve, technologically and intellectually.
Will we rise to the occasion?
🧵 What’s your take on cryoET’s challenges?
#CryoET #FutureOfBiology #ElectronMicroscopy
https://t.co/5HdGNOydcl

[Biophysics from Cambridge University Press @Biophysics_CUP]

1/8
Cryogenic electron tomography (cryoET) is a revolution already in motion!
@MishaKudryashev argues that in situ structural biology is exploding, forcing us to rethink cells, molecules, and collaborations: https://t.co/5HdGNOxFmN
Let’s unpack that 👇
#CryoET #StructuralBiology

[rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 @buildmodels]

"The AlphaFold advance was possible only because of the Protein Data Bank, a laboriously created database of protein structures that the National Science Foundation began funding in the 1970s. No Protein Data Bank, no AlphaFold."

https://t.co/xoFyzAJPV8

[rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 @buildmodels]

Myoglobin Fold (1987) by Irving Geis
Used with permission from the Howard Hughes Medical Institute. All rights reserved.
Learn more about Irving Geis and his his iconic images of DNA, hemoglobin, and other important macromolecules at PDB-101
https://t.co/mOVSr7R2JQ

[NVIDIA Healthcare @NVIDIAHealth]

🧩 We’re thrilled to collaborate with @StanfordMed and @HHMIJanelia on the Stanford RNA 3D Folding Part 2 Challenge.

Help advance the science of RNA structure prediction and push the boundaries of AI for biology.
Kickstart your solution with RNAPro, our new baseline model built on key insights from the first competition.

🤔 Can you solve it https://t.co/iQATEOv3Rm

[Das Lab @RDasLab]

Inspired by 2025 Stanford #RNA 3D folding @kaggle challenge outcome, we’ve collected cryo-EM of new-to-Nature RNA folds, RNA complexes with small molecules and proteins, and assemblies up to 6000 nts - and launched PART 2! Deadline: March 19, 2026. https://t.co/eHQ673sFm7

[rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 @buildmodels]

First Molecule of the Month of 2026: Natural RNA-Only Assemblies
https://t.co/oiBdEp4YTD

[Richard Held @rgsheld]

Main change is a better movie 😬

[John Briggs @BriggsGroup]

From @ZunlongKe, collaboration with @PeacockFlu @CrollTristan @Dr_Shepp @AbhayKot @influenzal @wendybarclay11

[John Briggs @BriggsGroup]

Our work on HIV-1 matrix, led by James Stacey and Dominik Hrebik @F4ustus, is in this week's @Nature.
Extended explanatory video from @MargotRiggi.

https://t.co/e4bKvzBZhn

[Curt Jaimungal @TOEwithCurt]

“Your worst sin is that you have destroyed and betrayed yourself for nothing.” - Fyodor Dostoevsky

[Das Lab @RDasLab]

First AI-generated RNA with novel atomically ordered 3D fold! With @eternagame @StanfordBiochem @chaitjo @PossuHuangLab @UWproteindesign @ShujunHe0717 @navtejtoor @HHMIJanelia on bioRxiv https://t.co/rO8OVU1Avd

[Saloni @salonium]

What made this dramatic change possible?

In the article, I describe the progress achieved and some concrete reasons behind it.

You can read it here:
https://t.co/6vgrJNR4x2

[Saloni @salonium]

I wrote a new piece on how much progress has been made in treating childhood leukemia.

The answer is: quite a lot!

Before the 1970s, fewer than 10% of children diagnosed survived 5 years after diagnosis.

Now most are cured and around 85% survive that long.

[Richard Shuai @richardwshuai]

Excited to share Caliby 🐈, our new model for structure-conditioned sequence design! Caliby is a Potts model-based sequence design method that can condition on structural ensembles. We use this to average out non-structural signal (e.g. evolutionary bias) learned by models 🧵1/N

[Aaron Ring @aaronmring]

We need a more nimble regulatory framework for outbreaks like hantavirus.

There is already a compelling therapeutic candidate: a human mAb isolated from a recovered patient, with strong preclinical activity against the Andes variant.

Yet access remains months to years away.