A structure of CXCR4 in complex with a de-novo designed miniprotein blocker determined at our @ANRFIndia facility @IITKanpur is published in @Nature! Spearheaded by the lab of Prof. David Baker (Nobel Prize, 2024) @UWproteindesign, it also involves @arshukla and team @IITKanpur.
Introducing gyaradax 🐉: A JAX solver for local flux-tube gyrokinetics with custom CUDA kernels for acceleration.
This entire code was vibecoded by @ggalletti_ and me in a month.
Validated against GKW (CPU-only Fortran code) with 10x speedups. Details and code in the replies.
Congratulations to @JunLiuLab@YaleMicroPath researcher @guowangbiao for receiving the poster award at the 11th Annual @Yale Biophysics and Structural Biology Symposium!
8/8
@MishaKudryashev puts it simply:
CryoET offers biological realism — but demands we evolve, technologically and intellectually.
Will we rise to the occasion?
🧵 What’s your take on cryoET’s challenges?
#CryoET#FutureOfBiology#ElectronMicroscopy
https://t.co/5HdGNOydcl
1/8
Cryogenic electron tomography (cryoET) is a revolution already in motion!
@MishaKudryashev argues that in situ structural biology is exploding, forcing us to rethink cells, molecules, and collaborations: https://t.co/5HdGNOxFmN
Let’s unpack that 👇
#CryoET#StructuralBiology
"The AlphaFold advance was possible only because of the Protein Data Bank, a laboriously created database of protein structures that the National Science Foundation began funding in the 1970s. No Protein Data Bank, no AlphaFold."
https://t.co/xoFyzAJPV8
Myoglobin Fold (1987) by Irving Geis
Used with permission from the Howard Hughes Medical Institute. All rights reserved.
Learn more about Irving Geis and his his iconic images of DNA, hemoglobin, and other important macromolecules at PDB-101
https://t.co/mOVSr7R2JQ
🧩 We’re thrilled to collaborate with @StanfordMed and @HHMIJanelia on the Stanford RNA 3D Folding Part 2 Challenge.
Help advance the science of RNA structure prediction and push the boundaries of AI for biology.
Kickstart your solution with RNAPro, our new baseline model built on key insights from the first competition.
🤔 Can you solve it https://t.co/iQATEOv3Rm
Inspired by 2025 Stanford #RNA 3D folding @kaggle challenge outcome, we’ve collected cryo-EM of new-to-Nature RNA folds, RNA complexes with small molecules and proteins, and assemblies up to 6000 nts - and launched PART 2! Deadline: March 19, 2026. https://t.co/eHQ673sFm7
Our work on HIV-1 matrix, led by James Stacey and Dominik Hrebik @F4ustus, is in this week's @Nature.
Extended explanatory video from @MargotRiggi.
https://t.co/e4bKvzBZhn
What made this dramatic change possible?
In the article, I describe the progress achieved and some concrete reasons behind it.
You can read it here:
https://t.co/6vgrJNR4x2
I wrote a new piece on how much progress has been made in treating childhood leukemia.
The answer is: quite a lot!
Before the 1970s, fewer than 10% of children diagnosed survived 5 years after diagnosis.
Now most are cured and around 85% survive that long.
Excited to share Caliby 🐈, our new model for structure-conditioned sequence design! Caliby is a Potts model-based sequence design method that can condition on structural ensembles. We use this to average out non-structural signal (e.g. evolutionary bias) learned by models 🧵1/N
We need a more nimble regulatory framework for outbreaks like hantavirus.
There is already a compelling therapeutic candidate: a human mAb isolated from a recovered patient, with strong preclinical activity against the Andes variant.
Yet access remains months to years away.