#easySHARE-Seq: Flexible and high-throughput simultaneous profiling of gene expression and chromatin accessibility in single cells | bioRxiv https://t.co/4lx5DErWPV
We created a cross-disorder atlas of the human DLPFC exploring inter-individual & cross-disorder transcriptome variations. We aimed to provide a foundational framework for targeted, cross-disorder treatments that address the molecular complexity of brain dysfunction. #PsychAD
Only the 1st installment with much more to come…the 1st ReDLat Genomics Report 🧬 highlights ancestral background and pathogenic variation! Full-sized ms w/local ancestry mapping, pedigrees, + detailed clinical vignettes will be in published paper! https://t.co/ETe1YeThUw
Check out our new preprint showing our ability to use epigenetic age measured from blood to predict AD progression & cortical atrophy! @dwsir @UCSFimaging @UCSFmac @nanosanta @AgustinMIbanez @Cornell https://t.co/QiB9IcvJhR
Cool work from @spyros_darmanis that performs combinatorial-based superloading of @10xGenomics for scRNA-seq and multiome assays. Interesting idea to add the 10x barcode first, then the second barcode later: https://t.co/b9UUYpcoIT
Stop by my poster tomorrow to hear about how progranulin insufficiency influences inflammation in response to TDP-opathy! October 6th from 8-12, poster C13! #sfn2024
If you’re at SFN this week, come by my poster! Especially if you like Tau, regulatory elements, and MPRAs. I’m excited to share what I’ve been working on during my postdoc. Poster B133 today (Saturday) from 1-5. #sfn2024#sfn24
We identified Widespread transposable element dysregulation in human aging brains with Alzheimer’s disease and validated it by CRISPR from @YinShenLab Thanks @NIHAging@CCLRI@YinShenLab https://t.co/vlWVLOy2DW
Dr. @bbrogers_, a postdoc associate in Dr. @jNickCochran's lab at HudsonAlpha, is embarking on a groundbreaking project with the @APDAParkinsons!
Learn more about the cutting-edge research she will be conducting now: https://t.co/rWs3jzJXyU
Excited to share our latest work is published @GenomeResearch! We explored allele-specific transcription factor binding across nine brain regions, offering new insights into gene regulation and the role of genetic variation in the brain https://t.co/eTcWqI1pN0 1/
Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics
Exciting work @RexachLab & @GeschwindLab, comparing #Alzheimers & other tauopathies
Suggests shared & disease-specific mechanisms of selective vulnerability & glia
https://t.co/BlJZIsZbAO
Excited to share that I’ve been awarded a fellowship from the American Parkinson Disease Association (APDA)! Thanks to APDA for their generous support and @jNickCochran for his mentorship in designing this project! @APDAParkinsons@hudsonalpha
APDA is excited to announce the inspiring researchers and exciting projects being funded for the 2024-2025 year! With $2.6 Million in new funding an increase of over 30 percent from the year before, find out more on our website and see the full list:
https://t.co/BXxctlFbK1
NEW: @jNickCochran & @RickMyers_PhD were awarded an @NIH grant to study a gene linked to various dementias. Their research could bring us closer to understanding and potentially treating different complex conditions.
Read more: https://t.co/FFIExPkctx
UPDATED: we have identified 313 (!) funding opportunities and fellowships for postdoctoral fellows.
Download this database freely here: https://t.co/EbTahdzJ9X
For each entry, we provide description, amount, deadline, eligibility, and link to funder.
Good luck!
Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n)
Link: https://t.co/MeEmOzMptv
Excited to share our preprint "Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome & epigenome". This work extends single-cell CRISPR screens to simultaneously profile gene expression & chromatin accessibility.
It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇
https://t.co/I2j2pAel69
📢Thrilled! My 1st piece of work of my postdoc at @Arlottalab is out @Nature! This has been a huge co-lead effort with @IreneFaravelli👩🔬👩🔬🤩
Link: https://t.co/9HmNVh0SQZ
Tweetorial 👇🧵
Interested in 3' UTR changes in scRNA-seq? Check out our:
* CPA-Perturb-seq paper
* UCSC Perturb-seq tracks (see who regulates your favorite 3’ UTR!)
* Seurat extension for polyA site analysis (PASTA)
* Deep neural perturbation network (APARENT-Perturb)
https://t.co/XXYEBHV1iG