David Foote

CEO - zennya health | Biologist & HealthTech Founder Building AI-driven home health systems for personalized care & longevity. 1M+ services delivered

[David Foote @davidrfoote]

@dr_ericberg High dosage creatine (10-15)g per day.

[David Foote @davidrfoote]

@JJonahJames2 @mamoun_linda She quoted Haaretz. One of the top news outlets in Israel and referenced an article written by an award winning journalist. And yet you chose to spend your time insulting her rather than taking a few minutes to educate yourself.

[David Foote @davidrfoote]

@wolfejosh @ComicDaveSmith This is not a serious standard for genocide. Genocide under international law is about intent and conduct not maximal capacity. Weren’t there a significant number of genocide scholars including Israeli that concluded this met the standards for a genocide ?

[David Foote @davidrfoote]

Calling dissent an “insurrection” after an unarmed American citizen is killed by masked federal agents is reckless.

Treating protest as “Democrat” and obedience as “patriot” is a false tribal frame that shuts down serious constitutional discussion.

I’ll be donating to Patty’s campaign.

[Aaron Levie @levie]

https://t.co/UVlRDGJu5I

[Andrew D. Huberman, Ph.D. @hubermanlab]

Important paper, also for adults who “enjoy” stimulants. A new class of actual focus enhancing stimulants is emerging too— and they seem to enhance REM duration that night. Most are for narcolepsy and no, not Modafinil. 2026 is going to be a banner year for Rx stimulants.

[David Sinclair @davidasinclair]

Modeling across seven nations shows that swapping meat and sweets for beans, nuts, and whole grains could add a decade to life expectancy https://t.co/CsySRVctyg

[Aaron Levie @levie]

We’re going to enter a new phase of AI where the average consumer may not perceive a huge difference in any one model upgrade, but specific industries will feel significant improvements occur.

The next phase of AI be about making models better and better for AI agents in real world knowledge work domains.

We’re going to see new evals emerge that test for relevant tasks in these spaces, the generation of high quality data and environments that align to real work, training against specific tools and software in these spaces, and more.

The test case of how to improve models on axis of real world capability has been proven out in coding, but now the same will start to happen across other high value fields like financial services, law, healthcare, life sciences and more.

We’re only at the very beginning of this cycle.

[David Sinclair @davidasinclair]

Boston-based @lifebiosciences is set to be testing age reversal in humans in the coming months. Stay tuned. Wish them luck🤞

[Arnaud Bertrand @RnaudBertrand]

Extraordinary words by Nvidia's CEO.

In polite terms, he effectively says that the chips export controls on China were one of the most self-destructive decisions ever taken by the US government: https://t.co/6SSe1ObSsN

He says it caused Nvidia to go "from 95% market share to 0%" in China, and that he "cannot imagine any policymaker thinking that’s a good idea. That whatever policy we implemented caused America to lose one of the largest markets in the world to 0%.”

In a separate interview (linked below) he effectively says that might have lost the US the AI race. Because, as he puts it, "winning" the AI race means that "80% of the world uses the American tech stack" and that, given that China on its own is "50% of AI research" and "30% of the technology market", then them not using the American tech stack means that by definition America is "forfeiting and conceding" the AI race.

In that separate interview he also completely ridicules the narrative - used by the US to justify the export controls - that they were to prevent "dual use" of advanced Western chips for military purposes by China, saying that "no government, surely the Chinese government, is going to be building their defense on Western technology nor does the Pentagon use Chinese chips to build our national security."

So to sum up: in a foolish attempt to slow China's AI development, not only did the US lose its largest market, they may have lost the AI race itself.

[Brandon Luu, MD @BrandonLuuMD]

The majority of exercise's benefits are gained in the first few minutes you do

Just 15 minutes of moderate daily exercise is linked to a 14% reduction in mortality

[David Sinclair @davidasinclair]

Muscles are an endocrine organ. When you move, they release molecules (myokines) that protect your brain, heart & immune system

[David Sinclair @davidasinclair]

Aging isn’t the buildup of damage, it’s the loss of information. The software (epigenome) gets scrambled, even if the hardware (DNA) is fine

The good news? Software can be reinstalled

[Eric Topol @EricTopol]

Why does the naked mole rat have the longest lifespan and healthspan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
https://t.co/gtkefjgWyi

[Bryan Johnson @bryan_johnson]

Omega-3s help muscles recover faster.

40% less soreness at 24h
30% less damage markers post-exercise

With EPA/DHA, athletes maintained muscle strength and range of motion. Those on placebo lost up to 40% of muscle strength and 20% of range of motion.

[Dr Singularity @Dr_Singularity]

This New Drug Could Be the Biggest Anti-Aging Breakthrough Since Rapamycin

Researchers at Queen Mary University of London tested Rapalink-1, a new drug based on rapamycin, known for extending lifespan in cells and rodents.

In yeast experiments, Rapalink-1 extended lifespan similarly to rapamycin. Molecular analysis showed it boosted enzymes that convert agmatine, a gut bacteria compound into other chemicals.

This conversion influences genes linked to aging, explaining part of Rapalink-1’s anti-aging effect.

[Derya Unutmaz, MD @DeryaTR_]

In my opinion, this is the most important aging-related paper of the year! It identifies a critical protein that could eventually extend lifespan by many years. Not surprisingly, it involves DNA repair and regulation of the immune response. Below is a breakdown of the key points (via GPT-5):

What did they find and why important?

•Naked mole-rats live a very long time and rarely get cancer.

•A key reason is a tiny change in a cell sensor called cGAS. This sensor usually detects stray DNA inside cells and sounds an alarm to the immune system.

•In humans, cGAS can drift into the nucleus and get in the way of one of our best DNA repair tools (called homologous recombination). That means more un-fixed DNA damage over time.

•In naked mole-rats, four small amino acid changes in cGAS flip the script. Their version does not block repair. Instead, it helps the high-fidelity repair process work better.

Why is this big for aging?

•Aging is partly the story of accumulating DNA damage. Better repair means fewer mutations, less cellular dysfunction, and a slower march toward age-related diseases.

•If we can make human cGAS behave more like the mole-rat version, we might reduce the daily damage load, which could:
•Lower cancer risk
•Preserve tissue function longer
•Delay multiple age-related declines at once

How could this translate to people?

1.Drug design: Create small molecules that keep human cGAS from interfering with DNA repair inside the nucleus, while still letting it do its normal immune-sensing job in the cytosol.

2.Protein engineering or gene therapy: Introduce cGAS variants that mimic the mole-rat’s four changes in high-risk tissues, carefully and locally.

3.Biomarkers and screening: Use cGAS activity and DNA repair efficiency as readouts to find who might benefit and to measure whether a therapy is working.

4.Combination strategies: Pair cGAS-tuning with other repair boosters and senescence-reducers for a bigger effect.

Bottom line:

A few precise tweaks to one protein can shift the balance from ongoing damage toward cleaner, faster DNA repair. That is exactly the kind of leverage aging research needs: change a small control knob, get system-wide benefits. The naked mole-rat just showed us one such knob.

Paper link in the thread.

[David Sinclair @davidasinclair]

I am very proud of the team at MetroBiotech, who have developed a stabilized, GMP grade, patented form of NMN & have taken it into multiple FDA-regulated clinical trials to treat major diseases. Why does this matter? 🧵

[Bryan Johnson @bryan_johnson]

A single night of 4 hour sleep can drop insulin sensitivity by up to 25%.

Your body handles carbs worse, stores more fat, and spikes glucose longer. Chronic poor sleep can lead to prediabetes.

What to do:
+ Prioritize 7.5+ hrs of sleep
+ Eat earlier (at least 4 hrs before bed)
+ No coffee 6 hours before bed
+ No heavy exercise 4 hours before bed
+ Keep your room dark and cool
+ Avoid blue light and screens 1–2 hrs before sleep

[David Sinclair @davidasinclair]

BIG NEWS. FDA reverses its 2022 stance: NMN is once again allowed to be sold in the U.S. as a dietary supplement

As a founder of the field, here's my take: 🧵