Dong Li

Cell biologist; Postdoc at UCSF. Interested in cell dynamics at the variable levels

[Dong Li @dongli02]

Super happy to share my latest PhD paper. In this work, we uncover a novel mechanism responsible for the branched F-actin polymerization in the rear of cells. This work reveals that Arp2/3-based actin carries out a previously unappreciated function in building the rear cortex.

[Journal of Cell Biology @JCellBiol]

.@dongli02, Yihong Yang, Huaqing Cai et al. delineate a signaling pathway responsible for the polarized assembly of cortical F-actin in rapidly migrating cells. https://t.co/q36FkbTpmI

🎥 See video summary by Dong Li: https://t.co/HlnEqazzhi

#Cytoskeleton #Migration #motility

[Luke Timmerman @ldtimmerman]

NIH cuts are hitting young scientists the hardest. By David Baker. https://t.co/mwFPkbp9OA

[Brisa Palikuqi @BrisaPalikuqi]

We need new members to join our lab! Please share!

[Dong Li @dongli02]

@HiroFujiwara congrats

[Dong Li @dongli02]

@yjgaoustc Congrats!

[Dr Naomi Moris @nmoris]

Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)

[Cedric Blanpain @CedricBlanpain]

I am delighted to share our new study published in ⁦@NatureComms⁩ in which we uncover a common mechanism by which collagen signaling and matrix stiffness regulate stem cell multipotency in glandular epithelia. https://t.co/8XLjcSRc7u

[Dong Li @dongli02]

@lizhuoai congrats, Lizhuo!

[Eric Topol @EricTopol]

New @Nature
A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells
https://t.co/bfyTkvWS1P
@vonMeyenn @laurahinte

[Zhen Gu @guzhenlab]

Our smart oral insulin ⁦@NatureNano⁩ ⁦@ZJU_China⁩ ⁦@JDRFUK⁩ ⁦⁦@JDRFResearch⁩ https://t.co/1Bpr8KgBYf

[Leo Yuan @greatysp]

Congratulations to Katie and the team at @ElaineFuchsLab

[Dong Li @dongli02]

@ReiterLab It is a really interesting paper and provides a lot of information. Inspired by this paper (preprint version), I have established the primary astrocyte culture.

[Eric Betzig @Eric_Betzig]

#FluorescenceFriday #cellbiology 3D dynamics of six organelles in a COS-7 cell as revealed by lattice #lightsheet microscopy with multichannel unmixing. In collaboration with @Valm_Lab and @cohenlaboratory, then in @JLS_Lab. https://t.co/T5Tg5xeMEC

[Dong Li @dongli02]

@KajimuraLab awesome!

[Muziyue Wu @MuziyueW]

Super excited to share my thesis work!

doi:https://t.co/w6apJ2tNvf

We found how cells manage to build the extremely flat and thin membrane protrusions with the WAVE complex, that organizes into a linear polymer-like structure at the tips of lamellipodia.

[Dong Li @dongli02]

It is good example how alphafold helps a cell biologist understands molecular mechanisms in more depth. Another interesting observation is that Leep2 is absent from the pseudopodia during cell migration, while enriched at the MP cups, a front structure similar to pseudopodia.

[Journal of Cell Biology @JCellBiol]

Predicted structures of the Leep2 complex. Chao, Yang, Cai et al. (Institute of Biophysics, CAS) identify a RasGAP complex that plays a specific role in the regulation of macropinosome formation. https://t.co/IHud0P3csm

@dongli02
#Organelles #Trafficking

[Dong Li @dongli02]

While the Nf1 mutation, a Ras GAP, is required to maintain high level of macropinocytosis in the axenic Dicty line, the Ras activity still needs to be optimized. This paper shows a novel RasGAP complex modulates Ras activity, which is important for macropinocytosis.

[Journal of Cell Biology @JCellBiol]

Xiaoting Chao, Yihong Yang, Huaqing Cai et al. identify a RasGAP complex that plays a specific role in the regulation of macropinosome formation. They demonstrate that both deletion and overexpression of this complex compromise macropinocytic activity. https://t.co/DhCKY011oS

[Scholarship for PhD @ScholarshipfPhd]

How to Write Clearly

[Dong Li @dongli02]

@BrisaPalikuqi Congratulations to you Brisa!

[Dong Li @dongli02]

@SeptinLab @NikonInst why is the membrane puncta like？not smooth？

[Dong Li @dongli02]

@KajimuraLab @phillipwhite14 Congrats!