Emily Davis-Marcisak, PhD

Human Genetics PhD @HopkinsMedicine.
F31 fellow studying immunology and single-cell genomics in pancreatic cancer. @FertigLab

[Moderna @moderna_tx]

mRNA-4157/V940 is an investigational personalized #cancer #vaccine consisting of a single #mRNA coding for up to 34 neoantigens that is designed to stimulate an immune response by generating specific T cell responses based on the unique mutational signature of a patient’s #tumor.

[Simona Cristea @simocristea]

New🔥 #DataScience #Bioinformatics resource: 850,000‼️ #scRNAseq cells from 226 samples across 10 cancer types draw a map of the tumor microenvironment, in particular fibroblasts.

Let’s see👇what are the main contributions of this work & what this means for #cancer #Genomics🧵

[Anirban Maitra @Aiims1742]

It’s spatial profiling day on @biorxivpreprint!
Now @10xGenomics out with a preprint on integrated single cell, spatial and in situ analysis of FFPE tissue. Very excited by the extension of these high dimensional technologies to archival samples!
https://t.co/2ekTRvIoAG

[Sophia Liu @immunoliugy]

Presenting Slide-TCR-seq: our method for measuring the transcriptomes of cells & T cell receptor (TCR) sequences in situ!

This collaboration w/ Bryan Iorgulescu, Shuqiang Li, Catherine Wu, and @insitubiology led to some cool findings...

https://t.co/bamg5yCToX
1/8

[Simona Cristea @simocristea]

Cancer #immunotherapy #DataScience resource of the week: #scRNAseq & #scTCRseq atlas of 400,000‼️T cells from 316 patients of 21 cancer types, derived from tumors, adjacent normal tissue, and peripheral blood.Half of data newly sequenced, half gathered from literature. 🧵(1/4)

[Emily Davis-Marcisak, PhD @efaithd]

@allisonoconn If you cook once a week for the entire week does that count? 😂

[de Miranda Lab @deMirandaLab]

The most recent paper from the lab has been published at @jitcancer. We employed single-cell mass cytometry to delineate tumor-associated and systemic immune profiles in #PancreaticCancer.
https://t.co/LAQKoVan1H

[Single Cell papers @scell_papers]

Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis https://t.co/sA8X8XsJA7

[Tanentzapf Lab @TanentzapfLab]

“This grant proposal describes breeding experiments in peas. This reviewer remains unconvinced about the translational benefits. Applicant should switch to a more economically important crop like wheat. Applicant’s productivity also an issue, no paper published in last 8 years”.

[Anirban Maitra @Aiims1742]

ICYMI @TheVinodLab @MSKCancerCenter recent adjuvant trial of an mRNA #vaccine in patients with #PancreaticCancer (a collaboration with @BioNTech_Group) was featured on @cnn (@drsanjaygupta).

[Jamie Heather @jamimmunology]

Here's a neat tech, where they capture T cells based on adherence to target tumour cells in a microfluidic device:
https://t.co/ToQATe275V

A fast assay that addresses a lot of problems from say sticky multimers, and twiddling the pressure lets you sort out high avidity binders.

[Omniscope @OmniscopeAI]

Minimize the chances of missing a T cell population critical to your therapy success!💪🏼

OS-T enables #TCR #sequencing of up to #1M #cells per sample at cellular resolution.

Submit your #abstract and opt-in to an opportunity to be awarded 4 free samples!

https://t.co/rzvpEoHKjb

[Dr. Neeha Zaidi @NeehaZaidi]

So lucky to have been able to work with @efaithd an incredibly talented, creative and overall amazing scientist! I have no doubt you will continue to do incredible work. Congratulations!

[Marco Kuenzli @KuenzliMarco]

How do different routes of #mRNA vaccination (made by @Tibabiotech) impact the differentiation and distribution of #vaccine elicited CD8 and CD4 T cell memory responses in mice? @TwiterlessBuck @Masopust_Vezys @niaidcivics

👇🏼
https://t.co/2IaxNQNsHd

[Eric Topol @EricTopol]

Our immune system follows circadian rhythm. A new review @SciImmunology. And why getting Covid vaccines in the morning elicits a better antibody and cellular immune response
https://t.co/nqDxy3XYv1 @ScheiermannLab

[Emily Davis-Marcisak, PhD @efaithd]

I earned my PhD yesterday! In person too! What a surreal feeling all around. Wildly thankful for my incredible mentors on this journey, @FertigLab @NeehaZaidi @DrLizJaffee and everyone who made this possible.

[Eric Topol @EricTopol]

It's a @NEJM case report, but a groundbreaking one. For a woman with refractory pancreatic cancer, genetically engineered T cells directed towards the KRAS driver mutation achieved substantial tumor regression
https://t.co/X7NuoRehtq

[Lugli Lab @luglilab]

Our new review ‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses” is out ⁦@NatImmunol⁩. Great team effort with Dietmar Zehn ⁦@LabOxenius⁩ Robert Thimme ⁦@teximmed2⁩ and Gustavo Almeida https://t.co/ZVOeYfMFoe