Cuts in NIH research grants will have a lasting negative impact on science and medicine in the U.S. Grants will continue to fund specific research costs, but essential infrastructure like labs, advanced equipment and support staff are crucial for groundbreaking work.
Our next journal club is on 7 Nov at 4pm ET/1pm PT! "Distinctive Evolution of Alveolar T-cell Responses is Associated with Clinical Outcomes in Unvaccinated Patients with SARS-CoV-2 Pneumonia" presented by Dr. @luisamnMD Morales-Nebreda. Register at https://t.co/PDa4S60aZm
Congratulations to Dr @oanheei & Dr @louiserowntree from the Doherty Institute for being awarded the @UniMelb 2024 Woodward Medal (Science & Tech) for their groundbreaking work on human T-cell responses to respiratory viruses, including COVID-19. 🌟👏 https://t.co/iJz1DDVHfy @UniMelbMDHS @TheRMH
TCR repertoire dream: decoding immune status by sequencing TCRs. Problems: 1) Need paired TCRab chains 2) Interesting T cell clones are often VERY small. Our solution: TIRTL-seq 🐢Deep, quantitative, & affordable paired TCR repertoire sequencing. 🧵 https://t.co/n90d3DLZHV (1/11)
At a recent conference @AthenaAktipis invited me to give a talk on the role of creativity in science. For those interested here are the illustrated slides in tweetorial format. The take home message: Creativity and science go hand in hand. (Thread 1 of 2)
So happy to share our incredible work, just published in @CellCellPress. We found that high expression of OLAH drives life-threatening immune responses. OLAH directly impacts disease severity in multiple globally relevant, but distinct viral infections. https://t.co/juMu6rXvrx
MIS-C is a rare post-COVID syndrome impacting children, though a direct connection between SCoV-2 & severe inflammation is undefined
In our new collaborative effort w/UCSF & Boston Children's, we find a cross-reactive epitope could be the MIS-Cing link. A🧵https://t.co/FPpCLFlyDn
Our latest, from the brilliant @wchenomics and @_Choi_Junhong, out in @Nature , is ENGRAM, a multiplex method for symbolic recording of signaling and cis regulatory activity to DNA. Final version (not in preprint) includes integration w/ DNA Typewriter. https://t.co/XmiIZSNWpv
Have you ever wondered why there are so many subtypes of immune cells? In our work published today at @Nature, we offer one possible reason – the capacity to evolve. 1/n https://t.co/oSFlSRhv59
NEW: @UMichSPH prof @AubreeGordonPhD has been awarded a $6.7 million five-year grant to advance her innovative research into influenza immunity development among children. "This study represents a monumental step toward understanding how early influenza exposure—whether through infection or vaccination—shapes the immune systems of children in the long term."
Read: https://t.co/g0ooOjx8Uj
Fantastic work in the Mechanisms of Lung Inflammation and Infection poster discussion session! @TimFlerlage presented incredible single cell data on influenza induced ARDS. Amazing to see a good friend and collaborator Yohannes Mebratu moderating the session! #ats2024
We've underestimated the role and activation of the immune system in patients with heart attacks. A comprehensive multi-omic analysis uncovers the role of T cells and monocytes
https://t.co/Icqm4afmyh
@NatureMedicine@KPekayvaz @LMU_Uniklinikum and colleagues
Tacos with friends on the water and puppy cuddles. Also, amazing science at the Charting lung omics session (not pictured). Great morning at #ats2024@aanaishe@TimFlerlage