Fabio

Genome engineer and all-round nerd.

[Fabio @fabiolib]

What a way to end my last day with GA4GH Secretariat. Big congrats to all the dev team and thanks to reviewers! This is a great day for the Global data sharing community. This version paves the way for a revolution in how data can be shared and analysed securely. #GA4GHforever

[GA4GH @GA4GH]

It’s finally here! #Passports v1.2 solves key #DataAccess problems: https://t.co/fmbUnfGEYC.🧵

Thanks @Doc_JmGAuvil @dbernick @nyronen @TomConn3r @maximum_bark @andrewpatto @SarionBowers @tsslade & many more!

[GA4GH @GA4GH]

It’s finally here! #Passports v1.2 solves key #DataAccess problems: https://t.co/fmbUnfGEYC.🧵

Thanks @Doc_JmGAuvil @dbernick @nyronen @TomConn3r @maximum_bark @andrewpatto @SarionBowers @tsslade & many more!

[Fabio @fabiolib]

Great to see this resource announced for the Global Spanish-speaking Genomics community. #GA4GH #GA4GH10thPlenary

[GA4GH @GA4GH]

Now available: the Data Use Ontology en #español https://t.co/xMSigvjb0P. We are pleased to add a Spanish translation of root #DUO terms for informational purposes. Thank you to Pablo Daniel Lapunzina @CIBERER, Aina Jené Cortada @CRGenomica, and Jonathan Lawson @broadinstitute.

[Adam Phillippy @aphillippy]

This project may be old news to preprint fans, so we had to come with some new content 😅 Today we are also announcing the first complete Y chromosome and a brand new UCSC @GenomeBrowser featuring all 24 #T2T human chromosomes! Info here: https://t.co/cAvqJ9agO2

[Mark Budde 🦕🏆 @markwbudde]

Primordium is now offering everyone the chance to sample our full-plasmid sequencing service for FREE - never use Sanger sequencing again! Please retweet this message and we'll DM you a coupon to sequence 5 ENTIRE PLASMIDS 100% FREE, no CC or PO needed. https://t.co/U4WeR2ftjL 5/

[preLights @preLights]

A new CRISPR command, Ctrl + PASTE: a method to insert large DNA sequences without double-stranded DNA breaks. @DrLouiseMoyle @silpasoni1 @fabiolib & @nozomu_takata highlight work from @omarabudayyeh & @jgooten 's lab
https://t.co/26dP4zyS9Z

[Jonas Koeppel @JonasKoeppel]

Prime editing can be used to precisely insert short DNA sequences into the genome. But what determines how efficiently any given sequence can be inserted? Joined forces @JulianeWeller, Elin Madli Peets, Ananth Pallaseni, @FabioLib, @LeopoldParts https://t.co/UOpbYDDbyO. A 🧵

[Jonathan Amos @JCDAmos]

Imagine how "spectacular" UK science would be if it received the sort of funding our major international competitors now invest. Sir Paul Nurse at this morning's @CommonsSTC hearing on UKGov R&D plans ahead of next week's budget/CSR.

[Sam Rodriques @SGRodriques]

It’s amazing to see the FRO concept get off the ground. Congratulations to @AdamMarblestone, @AGamick , @SchmidtFutures, and everyone else involved!! Everyone needs to be paying attention to this. For people who aren’t familiar with FROs, I’ll provide some background here.

[Tom Ellis @ProfTomEllis]

@ewjwallace This is such an important point. With synthesis, Golden Gate, and yeast we’ve regularly built 50 to 100kb stuff in a couple of days and then spent the rest of the month identifying the ones that really worked. It’s heading towards 90% of our effort in some projects

[Iain Macaulay @whatchamacaulay]

the term mindblowing is overused ... but this is just that.. biology, through the looking glass ... https://t.co/ggHJL1vGrw

[Pedro Beltrao @pedrobeltrao]

@EMBL and @DeepMind have teamed up to provide 350,000 pre-computed structural predictions for 21 species using AlphaFold - fuly accessible via https://t.co/SGSmozVRgt

[Mick W@tson ↙️ @BioMickWatson]

The human genome

[Oxford Nanopore Events @NanoporeConf]

5 more fantastic speakers added to our weekly round up! This week's list includes 11 human genome assemblies in 9 days, cross-kingdom pathogens & new methods to train methylation calling models. Read more: https://t.co/NaBKYdCJWW #nanoporeconf

[Zamin Iqbal @ZaminIqbal]

Retron-based high throughput screens!

"..single-stranded DNA produced by a retron element for recombineering. This enables libraries of millions of elements to be constructed and offers relaxed design constraints which permit natural DNA or random variation to be used as inputs"

[Daniel Bryan Goodman @dbgoodman]

This, please. 👇With enough volume, the cost could be very low, similar to a handful of Sanger reads. Would make my DNA-jockeying so much easier. See also: https://t.co/gwQyFke0G0

[Tom Ellis @ProfTomEllis]

Come join us! I’m looking for 2 #synbio postdocs to join my group as soon as possible to work on synthetic genomics. Eukaryote/Yeast experience desired.

Posts can be at @imperialcollege London or @sangerinstitute Cambridge depending on applicant preference. Please RT.

[Piero Carninci @carninci]

Pandora-seq: capturing all the small RNAs by removing modifications that usually prevent ligation and sequencing, reveals a new landscape including tsRNAs and rsRNAs; miRNA not the only/main class of small RNAs. Interesting thread.

[bioRxiv @biorxivpreprint]

Bacterial retrons enable precise gene editing in human cells https://t.co/L73jLeFJZ4 #bioRxiv

[Mo Khalil @MoKhalilLab]

1/ Synbio has potential to enhance next-gen therapies, but how can we make clinically-viable, therapeutic circuits in human cells a reality? Excited to unveil 1st of several papers trying to address this question, led by the brilliant @phdivya & Huishan Li
https://t.co/cN9YHKXlE5