Top Tweets for #Utuc
Underutilization of #germline #genetictesting
90% of eligible #patients w/ #urologic #cancer do not receive #germlinetesting
Of >125K eligible #patients w/ #cancer these had #germlinetesting:
#kidneycancer 9%
#adrenalcancer 9%
#UTUC 16%
#bladdercancer 8%
#prostatecancer 10%
100% of the above #patients w/ #urologiccancer met guideline eligibility for #genetictesting
"With #constantly #changing #guidelines, #varying #criteria across guidelines & #less #sensitive #guidelines, the authors propose the need for...#universally established guidelines...that effectively identifies most #patients w/ #genetic conditions."
(i.e. #Universal #germlinetesting for all #patients w/ #urologiccancer per #DrNealShore et al https://t.co/Ys7GqQ5FYk @JCOOP_ASCO)
https://t.co/7aT17UtELI #SriManivasagam & #JayRaman @urogoldjournal
c/w
https://t.co/C2PVcJ9GO9 @AllisonKurian et al @JAMA
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention @OncoDailyGU
#Universal #germlinetesting identified #LynchSyndrome-associated PGVs in 3.1% & overall PGVs in 6.3% of unselected #UpperTractUrothelialCarcinoma/#UTUC #patients... rates of MMR PGV parallel those reported in #CRC & #EC #patients undergoing #universal #germlinetesting per @NC@NCCN guidelines.
>60% of #patients w/ PGVs were missed by @NCCN criteria
#Universal #germlinetesting for all #patients w/ #UTUC
c/w
https://t.co/XsnpSVD18n @AminNassarMD et al @GIMJournal @TheACMG
&
https://t.co/tFSemI4b2i @EdEsplin et al @JCOPO_ASCO
&
https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO @ASCO
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention @OncoDailyGU
https://t.co/TilG2sb7Ez #DrJesseSpooner et al @UrolOncol
That’s a wrap on #BCANTT26! Thank you to @BladderCancerUS for the opportunity to share updates on our research in #UrologicCancers, including intermediate-risk non-muscle invasive bladder (IR-#NMINC) and low-grade upper tract urothelial cancer (LG-#UTUC).
@TyraBiosciences
#Germline P/LP variants occur in 10%-15% of #urothelialcancers, up to 20% in #UTUC
#Lynchsyndrome is the most common hereditary cause of #urothelialcancer
...#germlinetesting identifies a #therapeutically actionable subgroup with #Lynchsyndrome-
associated #MMR deficiency.
#Universal #germlinetesting in #UTUC & a #bladdercancer framework are overdue
https://t.co/KU89FhL4yI #DrStevenMonda et al @UrolOncol
c/w https://t.co/hnQ3qZQjSb @AminNassarMD et al @GIMJournal @TheACMG
#Universal #Germline #GeneticTesting for Hereditary Cancer Syndromes in #Patients With Solid Tumor #Cancer https://t.co/tFSemI4b2i @EdEsplin et al @JCOPO_ASCO
#Universal #Germline and Tumor #GenomicTesting Needed to Win the War Against #Cancer: #Genomics Is the #Diagnosis https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO @ASCO
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention @oncodaily @OncoDailyGU @CGAIGC
Glad to have written an invited editorial on this with @SLChang1. Congrats to the JCOG1403 Authors on their @LancetOncology paper and moving the needle toward better care for UTUC patients. #UTUC #pirarubicin #nephroureterectomy
🚨 JCOG1403: One dose. Within 24 hours. Meaningful benefit in RCT
@TheLancetOncol
👉 After nephroureterectomy for UTUC, a single intravesical chemo/pirarubicin instillation
⭐️Improved 3-year relapse-free survival:
💉 60% vs 47%
📉 HR 0.67
🎯 NNT = 12 to prevent one bladder recurrence
⚠️ Grade 3 hematuria: 3%
➖ No overall survival benefit
@SUO_YUO @UroOnc @renalandurology @urotoday @UrologyTimes
🔗https://t.co/g243nh6alh
#kidney_sparing #UTUC
Missed lower third tumour was a cause of recurrent hematuria after TURBT of posterior wall large T1G3 &BCG
Cytology/ diagnostic Reno-ureteroscpoy/ biopsy and laser ablation @Endo_Sec_Eua @smasultan62 @endouroacademy @Uroweb
Te invitamos a disfrutar del capítulo dedicado a Betsabeé Romero en la tercera temporada de la serie #UTUC, una colaboración entre #HaciendaEsPatrimonioCultural y Canal Catorce.
#Retransmisión: sábado 13 de junio, 18 h, a través de la señal de Canal 14.
Thank you to everyone who joined @BladderCancerUS and our team at @TyraBiosciences for the first-ever #UTUCAwarenessDay. Keep the momentum going and learn more about #UTUC: https://t.co/MRRL5FkY1F
This is how a pyelic #linfoma looks like … more solid than #UTUC Look how good is #thulio laser by @DornierMedTech : sharp enough to incise the tumor base combined with strong coagulation so that operative field is completely bloodless making #enbloc resection possible also inside the kidney #ETCE.
🔥@UrolOncol May issue! #UTUC
Is More Better? Evaluating Neoadjuvant Chemotherapy Cycles Before Surgery for High-Risk Upper Tract Urothelial Carcinoma by @taibo_li and @nirmishsingla et al.
🔗https://t.co/VzsBEho21h
We are proud to announce the first-ever Upper Tract Urothelial Cancer (#UTUC) Awareness Day! In partnership with @BladderCancerUS, we created #UTUCAwarenessDay to help raise awareness, expand education, and connect those impacted by this complex disease: https://t.co/nGU7aVvZzt
The #ENLIGHTED Phase 3 Trial: Advancing treatment of low-grade upper tract #UrothelialCarcinoma (LG #UTUC) with padeliporfin vascular-targeted photodynamic therapy. Presentation by Vitaly Margulis, MD @UTSWMedCenter. #AUA26 written coverage by @RKSayyid @UAUrology > https://t.co/2tjJwsKmb2 @AmerUrological #AUA26
Long-term follow-up results of aMVAC arm of ECOG-ACRIN EA8141: a prospective phase II trial of neoadjuvant systemic chemotherapy followed by extirpative surgery for patients with high-grade #UTUC. Presented by Ali Zahalka, MD @UTSWMedCenter. #AUA26 written coverage by @RKSayyid @UAUrology > https://t.co/z6Lpok9Yyh @AmerUrological #AUA2026
#MachineLearning–based prediction of progression to radical nephroureterectomy after endoscopic management of upper tract #UrothelialCarcinoma. Presentation by @srisaran027 @PennStHershey. #AUA26 written coverage by @RKSayyid @UAUrology > https://t.co/yFkfpakv0j #UTUC @A@AmerUrological AUA2026
A split-function approach to estimate post-surgical kidney health in upper tract #UrothelialCarcinoma #UTUC. Kieran Lewis @ClevelandClinic joins @UroCancerMD @VUMCurology presents a parenchymal volume-based model (PVA+) predicting GFR after nephroureterectomy to guide chemotherapy timing in upper tract urothelial carcinoma. #WatchNow > https://t.co/GcH8L6mods
📺 Watch @DocMattCampbell and @mjmoussa_ of @UTMDAnderson share findings from their study exploring the use of immune checkpoint inhibitors in patients with deficient mismatch repair/microsatellite instability–high #UTUC: https://t.co/fucnvxethl
🔥@UrolOncol April issue! #UTUC
Venous invasion in upper tract urothelial carcinoma: Diagnostic features and oncologic outcomes by Stephan Brönimann, @nirmishsingla, et al @brady_urology
🔗https://t.co/Wtm1qJMybF
💫🌟#UTUC: same disease… different guidelines?
@EUplatinum @OncoAlert
A thought-provoking editorial in European Urology highlights key divergences between AUA and EAU recommendations in upper tract urothelial carcinoma.
🔹 1. A rare disease, fragmented evidence
UTUC has long been managed by extrapolation from bladder cancer
👉 But biology and clinical behavior are clearly distinct
🔹 2. Where guidelines diverge
• 🔍 Diagnosis & staging → variability in imaging and nodal assessment
• 💊 Perioperative strategy → timing of chemotherapy (neoadjuvant vs adjuvant)
• 🧬 Systemic therapy integration → evolving role of IO and adjuvant approaches
👉 Reflects not only evidence gaps… but regional practice patterns
🔹 3. The real issue: evidence vs reality
• Limited prospective trials
• High rates of clinical vs pathological discordance
• Persistent uncertainty in risk stratification
💡 My take:
This is not just about guideline differences.
It’s about the challenge of practicing precision oncology in rare tumors with limited data.
👉 We don’t need more guidelines
👉 We need better, UTUC-specific evidence
@ecancer @MedicalwatchHQ @urotoday @UrologyTimes
🔗 https://t.co/oC9h4FqXLP
#UTUC #UrothelialCancer #GUOnc #PrecisionOncology #OncoTwitter
A split-function approach to estimate post-surgical kidney health in upper tract #UrothelialCarcinoma #UTUC. Kieran Lewis @ClevelandClinic joins @UroCancerMD @VUMCurology presents a parenchymal volume-based model (PVA+) predicting GFR after nephroureterectomy to guide chemotherapy timing in upper tract urothelial carcinoma. #WatchNow > https://t.co/GcH8L6mods
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