Max Valenstein, MD, PhD

@MGHMedRes Stanbury PSP @MGHMedicine | Alum @HarvardMITMDPhD @HarvardMed @MIT_HST @MITBiology @Yale @YaleMBB

[Max Valenstein, MD, PhD @mlvalenstein]

Congratulation to @DrMartyTaylor et al! Grateful to have played a small part in this

[Marty Taylor, MD PhD @DrMartyTaylor]

How can the same "master regulatory" protein mTOR recognize different sets of targets to separate nutrient and growth factor signals?

Thrilled to share our new paper, in which we reveal how mTORC2 recognizes Akt.

🧵 on our new paper in Science:
https://t.co/PSZWMsEYbn

[Max Valenstein, MD, PhD @mlvalenstein]

Thanks @chivukula_raghu! Now, back to being the Bigelow JAR...

[Raghu Chivukula, MD PhD 🫁🧬🧠 @chivukula_raghu]

Yet another beautiful piece of structural and biochemical work led by by friend, colleague, and @MGHMedicine resident @mlvalenstein! Thrilled to have contributed in a small way to this important study. Congrats to @plalgudi11, @DMSabatini, Kacper, et al.

https://t.co/CewerS1AN6

[Max Valenstein, MD, PhD @mlvalenstein]

A special shoutout here to @plalgudi11, seen here helping to spot *the grids* almost four years ago to the day at MIT!

[Max Valenstein, MD, PhD @mlvalenstein]

https://t.co/BT1fHZ3eU6

[Max Valenstein, MD, PhD @mlvalenstein]

Please check out the beautiful videos, rendered by Kacper, that bring these proteins to life!

[Max Valenstein, MD, PhD @mlvalenstein]

Grateful to have contributed a (very) small part to this fantastic work. Congratulations to @jason_yang0, @chivukula_raghu, et al!

[Raghu Chivukula, MD PhD 🫁🧬🧠 @chivukula_raghu]

This work was led by @jason_yang0 (now @BrunetLab) and aided by a talented and hardworking team: Forrest Xu, David Ziehr, @DrMartyTaylor @mlvalenstein @genfren Jack Bush, Kate Rutter, Igor Stevanovski, @CharlieYShi Mahesh Kesavan, @RMouroPinto @IDeveson David Bartel @DMSabatini

[Max Valenstein, MD, PhD @mlvalenstein]

@DanaFarberNews @CellPressNews @DanaFarber @XinGu0317 Fantastic work!

[Max Valenstein, MD, PhD @mlvalenstein]

In this week’s @Nature, we report that nutrients do not activate mTORC1 through degradation of GATOR1 component DEPDC5. Other molecular events signal the presence of amino acids to this essential growth pathway!

https://t.co/TrkxOFnfI5

[Mass General Brigham Research @MGBResearchNews]

In a new study published in @PNASNews, researchers from @MGHMedicine and colleagues investigated how cells sense and respond to the presence of nutrients.

Read more: https://t.co/nsgJjVJgbb @mlvalenstein @chivukula_raghu @DMSabatini

[Max Valenstein, MD, PhD @mlvalenstein]

It will be exciting to explore how they function in specific lysosomal and lysosome-related compartments.

Congrats to all involved, particularly @plalgudi11 and @XinGu0317!

Read more here: https://t.co/ClfdBa3yje (2/2)

[Max Valenstein, MD, PhD @mlvalenstein]

Out in @PNASNews now, we find that the Rag-Ragulator heptamer anchors the GATOR supercomplex to the lysosome. Our results highlight the complex role the Rags play in regulating mTORC1 activation and lysosomal homeostasis (1/2)

[Jose Florez @JoseFlorezMDPhD]

The @mghmedres Stanbury program attracts and trains top physician-scientists. At this year's summer retreat, @MGHMedicine family member @RWalensky shared her insights on matters relevant to her tenure as @CDCgov Director.

[Max Valenstein, MD, PhD @mlvalenstein]

@XinGu0317 @DMSabatini @DFCI_CancerBio @HarvardCellBio Fantastic work

[Max Valenstein, MD, PhD @mlvalenstein]

@XinGu0317 @ScienceMagazine Fantastic work!

[Max Valenstein, MD, PhD @mlvalenstein]

@QuastJP @bradyajohnston I think I've seen that model before...

[Max Valenstein, MD, PhD @mlvalenstein]

@RobertoZoncu @structureltp @LoewithLab @shenk0128 @EgriShawn @kbrogala @DMSabatini This is a beautiful structure! Congratulations to @structureltp and @LoewithLab. This thing is a real beast

[Max Valenstein, MD, PhD @mlvalenstein]

@XinGu0317 @Nature @PJouandin @PerrimonLab Fantastic work!

[Max Valenstein, MD, PhD @mlvalenstein]

You catch more flies with leucine! Congratulations to @XinGu0317 and team for revealing that nutrient sensing by mTORC1 influences dietary choices in Drosophila! Read it to see what the buzz is all about!🪰🍎 https://t.co/24p0c5spAY