Leo Scheller

Mammalian #synbio 🧬: Protein design for immunotherapy, CAR-T, receptors, signaling -

[Leo Scheller @Scheller123]

I’m happy to share that I will join the LIT in Regensburg (https://t.co/Y6ukzliOWn) as a Group Leader in Structural Biochemistry in May! More updates on Bluesky or LinkedIn 🙂. (This will be my last post here for now.)

[Daan C. Swarts @DCSwarts]

This is 🔥🔥🔥!

@MartinPacesa, Lennart Nickel, @befcorreia @sokrypton, et al. developed BindCraft - an open-source pipeline to design de novo binders for basically any protein of interest.

We asked if we could design binders for CbAgo - a DNA-guided DNA interfering Argonaute..

[Simon Duerr @simonduerr]

This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) https://t.co/qYzIsbr0TH

[GASB SynBio @gasb_synbio]

Congratulations to @igemmarburg and iGEM Heidelberg for winning the Grand Prize🥳!

[TU München @TU_Muenchen]

Congratulations to David Baker on receiving the #NobelPrize in #Chemistry! 👏 As a Distinguished Affiliated Professor at our university, the #biochemist is being awarded the prize for his work in the field of computational #proteindesign: https://t.co/sEK02q20xx

📷U.Benz

[News from Science @NewsfromScience]

This year’s #NobelPrize in Chemistry has gone to David Baker “for computational protein design,” and Demis Hassabis and John Jumper “for protein structure prediction.” https://t.co/KYISlA4scj

[Lukas Milles @LFMilles]

Excited to join the Gene Center at LMU @GeneCenter_LMU @LMU_Muenchen as a professor, looking forward to design some cool and unusual de novo proteins here!

[Itai Yanai @ItaiYanai]

Doing good science is 90% finding a science buddy to constantly talk to about the project.

[Irene Beusch @pauletteoctopus]

If you or someone you know is curious about #splicing, the Beusch lab (https://t.co/xz2JrCRzYR) @Uni_WUE is hiring PhD students! Check out the official advertisement here: https://t.co/wF6hQdqwlv - still a chance to apply till Oct 15th!

[Martin Pacesa @MartinPacesa]

Here is the link to the Colab, let us know if you have any problems or you have a hard target our pipeline cannot design against! We want to keep improving it and community feedback is very important 🙏🏻💻

https://t.co/TXAvgyQ6Rx

[Martin Pacesa @MartinPacesa]

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. @befcorreia @sokrypton

https://t.co/IPhMFpRgHh

[Simon Duerr @simonduerr]

There is a new tool on BioIcons to turn any protein (in PDB format) into a 2D vector illustration in SVG format. You can upload any PDB file or import from PDB, AlphaFoldDB or ESMFoldDB. Feedback welcome :)
https://t.co/grMysO8JV5

[Leo Scheller @Scheller123]

Congratz Martin and Lennart, to me this is not unexpected at all 😁 👏 🙌

[Martin Pacesa @MartinPacesa]

Wow, this is really unexpected! Designs were done together with Lennart Nickel in @befcorreia lab. Our pipeline will be fully open source and preprint online hopefully next week 🙂

[Martin Pacesa @MartinPacesa]

Wow, this is really unexpected! Designs were done together with Lennart Nickel in @befcorreia lab. Our pipeline will be fully open source and preprint online hopefully next week 🙂

[Kelvin Lau 🧬🧪💎 @klausenhauser]

Congrats to @MartinPacesa !!! The first two hits were pretty much identical to known binders so are not counted in the leaderboard

[Neural Cell News @NeuralCell]

In this new @CIR_AACR study, Drs. @darelmb, @MiglioriniDenis, and team at @unige_en validate PTPRZ1 as a #glioblastoma target and prompt the clinical translation of anti-PTPRZ1 CAR T cells. 🥼

Give it a read: https://t.co/xSg1F7AYBW

[Waggoner Lab @LabWaggoner]

IL2 muteins with directed disruption of aggregation sites enable enhanced specificity coupled to improved production capacity @LabListon
https://t.co/QWHWiEAetP

[Sergey Ovchinnikov @sokrypton]

AlphaFold3 reproduced and params/code released. 🤩

[Li Tang @Tang_Lab_EPFL]

Leman Biotech is excited to announce the successful treatment of the first pediatric patient with an extremely low dose (1%), who achieved complete remission and was discharged without complications. https://t.co/DjvTR1H9tv

[Motoyuki Hattori (服部素之) @HattoriLab]

The Google Colab version of RFdiffusion with the conditional fold generation option worked well! We successfully placed two helices in the beta barrel structure. The RMSD between prediction and X-ray is only 0.3 Å!

https://t.co/LEkjDJOEnf

https://t.co/QWYdIApu9a