Kyle G Daniels

Assistant Professor @Stanford University Genetics. Synthetic Biologist // Real Human 🧬 🔬 💻 🏳️‍🌈 🏊🏾‍♂️

[Kyle G Daniels @ScienceKyle]

🚨What if we could reliably program macrophage polarization state?🚨

https://t.co/6qGxuHptQq

Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)

[Samarth Hegde @samhegde2006]

🌟 In a month, the Hegde Laboratory opens at @EinsteinMed. While this marks the culmination of more than a decade of research with exceptional mentorship, it also represents an exciting new chapter in our collective quest for the development of next-gen myeloid drugs. 🧵👇

[Klebanoff_Lab @KlebanoffLab]

🚨3rd paper in our PI3Ka public neoantigen trilogy is out in @PNASNews! We show that HLA micropolymorphisms govern whether a neoantigen is visible to T cells by tuning neopeptide dynamics, not presentation or static structure. @MSKCancerCenter @parkerici
https://t.co/e8b9JDrQro

[Mo Khalil @MoKhalilLab]

🚨 An exciting frontier is bringing synthetic biology to MULTIcellular systems. To effectively engineer them, we need design principles. What are the benefits of group formation? What are the costs? See our new preprint led by @HeidiKlumpe to learn more!👇
https://t.co/Yc51Dx2KAf

[Polly Fordyce @fordycelab]

Characterizing AI-designed proteins requires quantitative biochemistry at massive scale. Enter Amplicon/Protein Bead Display (APB-Display), a fully in vitro platform that quantifies Kd's for >100,000 variants in <3 days (preprint link below!) @Stanford_ChEMH @czbiohub (1/n)

[José Dinneny @Dinnenylab]

Outstanding new work by my colleague @Barnabas_Daru at Stanford University!Biogeographic processes underlying global patterns of plant diversity | Science https://t.co/zfyZRMmF1i

[Kyle G Daniels @ScienceKyle]

@Abhinavsns @anshulkundaje Some of us are actually chief problem creators 🤪

[Kyle G Daniels @ScienceKyle]

Genuinely envious of all the cool people doing cool projects here 🥳

[Stanley Qi @stanleyqilab]

Excited to announce that the @stanleyqilab & Dr. Wing Wong are partnering with the Biohub network to reprogram the body's defenders!
Honored to be part of this incredible cohort of teams pushing the boundaries of synthetic immunology. https://t.co/RRPCzJhvt3

[Jalal @Jalal_Ahmed]

Thrilled to share our new paper out today in @NatureCancer:

Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases.

A single dose of radiotherapy makes CAR T cells work against extensive metastatic lung cancer — even when the target antigen is also on normal tissues.

https://t.co/4xHTzjNOc8
🧵 (1/14)

[Kyle G Daniels @ScienceKyle]

@CterminiPhD @myron_evansPhD 🥳🥳

[Matteo A. Molè @matteo_mole]

Had a fantastic retreat and inspiring scientific discussions with our collaborators! So great to exchange ideas with the Ryann Fame lab and Sarah Bowling lab @Stanford. Looking forward to where our science takes us! #ScienceTwitter @LabFame @SarahBowling15

[Stanford Neurosurgery @StanfordNsurg]

Charissa Chau’s glioblastoma battle inspired her husband, Antoine d’Haussy, to raise $50K for GBM research—split between two labs, including the lab of @MichaelLimMD 🧠. A micro-effort showing small acts add up ⚡ Read the full story here: https://t.co/nP2rjJHFwx.

[Prof. Michael Lin @MichaelLinLab]

Protein/enzyme engineering has a severe bottleneck — and it's not in AI modeling or compute time.

It's in actually building and testing protein variants.

Proud to introduce our latest work, MIDAS: a way to go from primers to protein assays in mammalian cells in one day. 🧵

[Kyle Farh MD PhD - Illumina AI Lab @KyleFarh]

When linear models and deep learning give the same results, orders of magnitude more training data are needed https://t.co/gcjjIjWhf3 ;

[Matt Higgins @ParasiteMatt]

Our latest study of the scavenger receptor CD163, led by @RichardZhou_. This follows our previous study of how CD163 uses its remarkable molecular architecture to bind haptoglobin-haemoglobin. We now show how its flexible arms allow haemoglobin binding and ligand promiscuity.

[Nature Biotechnology @NatureBiotech]

DNA-guided CRISPR–Cas12 for cellular RNA targeting https://t.co/BaFeG4leOS

[Kyle G Daniels @ScienceKyle]

🚨What if we could reliably program macrophage polarization state?🚨

https://t.co/6qGxuHptQq

Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)

[Sanjeev Herr, MD, MS (he/him) @SanjeevHerr]

Officially Dr. Sanjeev Herr, MD, MS!

Looking forward to a productive post-doc year and then reapplying and matching into neurosurgery next cycle!

[Mo Khalil @MoKhalilLab]

HONORED to receive the Kuwait Prize! A testament to the achievements and hard work of Khalil lab members past and present. It’s an honor to be recognized as a scientist, and especially meaningful to celebrate my background as a Palestinian-Jordanian 🙏
https://t.co/4Xw3Y6axgP

[Polly Fordyce @fordycelab]

High-throughput biochemistry enables quantitative characterization of proteins at scale -- but now synthesis of isolated, sequence-validated libraries has become a bottleneck. Check out @MicahOlivas1 & @patrickalmhjell's new preprint to solve this! @Stanford_ChEMH @czbiohub

[Kyle G Daniels @ScienceKyle]

@HindRafei Thank you. We’ve also been using the SCR in NK cells, so CISH and (your insights into) CREM have become important!

[Kyle G Daniels @ScienceKyle]

🚨What if we could reliably program macrophage polarization state?🚨

https://t.co/6qGxuHptQq

Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)