Thiago Andrade Patente

Doctor in Immunology from USP and current Post Doc @EvertsBart lab working with Immunology and Immunometabolism. #DendriticCells #Immunology 👨🏻‍💻👨🏻‍🔬🔬

[Thiago Andrade Patente @thiagoapatente]

I was inactive on X for a long time, and I forgot to share a huge milestone with you here. My Postdoc paper was accepted at @ScienceAdvances

https://t.co/bgxhJiQ0fS
Back in 2018, I moved to the Netherlands for the first time to do an internship in Bart Everts' lab.

[Thiago Andrade Patente @thiagoapatente]

@RafaJArguello @ScienceAdvances Thanks Rafa! Me too! I entered again recently! How are things going?

[Thiago Andrade Patente @thiagoapatente]

I was inactive on X for a long time, and I forgot to share a huge milestone with you here. My Postdoc paper was accepted at @ScienceAdvances

https://t.co/bgxhJiQ0fS
Back in 2018, I moved to the Netherlands for the first time to do an internship in Bart Everts' lab.

[Thiago Andrade Patente @thiagoapatente]

What about IBD and other inflammatory gut diseases? I hope we can answer these questions later. For now, I am very happy that the paper is out.

Thank you to everyone who helped me get there. I hope you enjoy the reading :)

[Thiago Andrade Patente @thiagoapatente]

We replicated these findings in ex vivo DC-T Cell co-culture, also demonstrating the importance of TGFb and AMPK in this axis.

This raises questions for new projects, such as which intestinal factors drive AMPK activity in the gut? Is this a Type 2 immunity-specific axis?

[Waggoner Lab @LabWaggoner]

Metabolic sensor AMPK licenses intestinal CD103+ DCs to induce Treg responses @LUMC_Leiden
https://t.co/1EEVQrJl1T @ScienceAdvances

[Thiago Andrade Patente @thiagoapatente]

@JustinPerryPhD @YourFriendAJT @ThePerryLab @MSKCancerCenter Congrats Justin. Nice job

[Thiago Andrade Patente @thiagoapatente]

Congrats @cica_dups on your paper! Always knew you would fly high!!!!

[Cecilia Pessoa @cica_dups]

Thrilled to share my paper! 🙌https://t.co/uD6QnUU1OL It was an incredible experience working and exploring such a fascinating story. Huge thanks all co-authors, they r amazing ppl, and everyone in the Zon Lab @leonard_zon for all their support both in and out of the lab! 😍

[Thiago Andrade Patente @thiagoapatente]

@Joana_BrasNunes @MEIjsselsteijn @NFdeMiranda @EvertsBart @ahmedElkoussy @MartinGiera Nice!!! Congrags @Joana_BrasNunes!!! Well deserved!

[Thiago Andrade Patente @thiagoapatente]

@Jeff_Mold @Satpathology @katha_lahl @IsabelUlmert @JExpMed 3. When we stain igLNs (that barely contains any epithelial cell) the LCs are easy to see after removal of B and T cells. You can see here the level of MHC and CD11c expression in the migratory APC compartment in the igLN and the EpCAM expression in these cells.

[Thiago Andrade Patente @thiagoapatente]

@Jeff_Mold @Satpathology @katha_lahl @IsabelUlmert @JExpMed 2. But the expression of EpCAM on DCs, and especially on LCs, is quite established and well known in the literature. I have already sorted LCs (based on EpCAM and other markers) and were quite efficient in priming CD8+ T cells, although less efficient than cDC1.

[Thiago Andrade Patente @thiagoapatente]

@pedromics The reasons why I want to leave as well

[Thiago Andrade Patente @thiagoapatente]

@J_my_sci @GarciaLabMS @urban_ecologist I don’t know what is your area of research, but in biological field, pretty much all of them require separate files. Here is the guidelines for for @JCellBiol, for example.

[Thiago Andrade Patente @thiagoapatente]

Our new paper is out today @JCellBiol. This work was developed as the PhD of @Eline_Brom with the supervision of @EvertsBart. Very glad everything worked out and is now out! Thank you everyone who helped us put this out and congrats @Eline_Brom! You deserve it!

[Journal of Cell Biology @JCellBiol]

Brombacher, Patente, Everts et al @LUMC_Leiden find that AMPK promotes #DendriticCell tolerogenicity by increasing breakdown of glycerophospholipids, enhancing mitochondrial fission–dependent fatty acid oxidation, & upregulating glucose catabolism https://t.co/GvSuPM9kSW