How open is “open” chromatin? Our new Nature Genetics paper uses nucleosome-resolution modeling to reveal condensed euchromatin domains with short, accessible regulatory regions at the surface. https://t.co/jcXwe5QDvn
Are weak TF motifs important? @ZeitlingerLab use deep learning to systematically map low-affinity pioneer binding sites in mESCs and show that they cooperate with strong motifs to open chromatin. Preview w/ @gracecbower: https://t.co/V3mmqmeJPG Paper: https://t.co/lEZnhrCZiI