AndreasAufschnaiter

Cell death enthusiast. MSc molecular medicine, atm persuing PhD on oncolytic viruses in Innsbruck AUT🇦🇹. Ferroptosis believer. Not too bad at sports climbing.

[Nature Rev Immunol @NatRevImmunol]

Comparative insights into the apoptosome, inflammasomes and PIDDosome https://t.co/iqj8UOu7RP

[Molecular Cell @MolecularCell]

Online Now: The landscape of regulated cell death: It’s all downhill from here https://t.co/6sDPE2njS3

[AndreasAufschnaiter @whateveroptosis]

https://t.co/vDEaaOTEND

[AndreasAufschnaiter @whateveroptosis]

the landscape of cell death is online! Spent half a year in Seattle, WA in Andrew Oberst's lab, where we came up with a new way to conceptualize cell death commitment, similar to Waddington's famous landscape of lineage commitment! Thanks TJ and Andrew! #celldeath (free access👇)

[AndreasAufschnaiter @whateveroptosis]

https://t.co/PMvy53w9P7
see you over there.. ✌️

[AndreasAufschnaiter @whateveroptosis]

@JonathanMannio1 @MitosRUs @Tummers_Bart @MeierLabICR @ICR_London @CR_UK @BreastCancerNow congratulations 🎉

[Marina Schapfl @MarinaSchapfl]

So happy to see this in print: https://t.co/IhiBI99iAF
We show that B cells have extra centrioles during some developmental stages and that centriole loss arrests B cell development at this stage! 🥳 @NatureComms @villunger @AHollandLab

[Dario @dario_rizz]

Hey Halloween fans, check out our latest paper! We’re diving into the fascinating world of the PIDDosome and how it activates the hitman Caspase-2 to kill cells that fail cytokinesis. Guess what? Caspase-2’s secret weapons are BID and p53! https://t.co/apml0F0uEW

[AndreasAufschnaiter @whateveroptosis]

really curious about the direction of this crazy field.. so many challenges, but also so much potential!

[nature @Nature]

DNA is an appealing medium for data storage because of its amazing data density — a single gram can store 215,000 terabytes https://t.co/s5DDH4fh4s

[Gene Regulation @generegulation]

Parallel molecular data storage by printing epigenetic bits on DNA https://t.co/liKoFlorVu

[AndreasAufschnaiter @whateveroptosis]

@globalimmuno @jkagan1 hi, thanks for that cool talk! is the receptor or the mechanism allowing PGPC hyperactivating DCs known?

[Pereira Lab @CellReproLab]

1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in @ScienceMagazine.
https://t.co/yPDqKmpGnn
Here is a summary of what we discovered!

[AndreasAufschnaiter @whateveroptosis]

@Interferon_G @jkagan1 just read your paper https://t.co/PdBa4nkzRe !! fascinating mechanism! reminds me of RHIM- or DD-dependent oligomerization (and subsequent effects) during cell death..

[AndreasAufschnaiter @whateveroptosis]

@Interferon_G @jkagan1 if one would have some money left over, one could set up a crispr screen targeting pLxIS motivs, and measure IFN response &antiviral states after infection, right? but I guess also in steady states where there's always some base level of endogenous triggers of immune receptors..

[AndreasAufschnaiter @whateveroptosis]

@Interferon_G @jkagan1 @Interferon_G interesting! Are you suggesting that there might be some kind of feedback or interplay from PRRs ("in") to the proteasome/Golgi/MHC ("out")? so that in cases where nuclear transport is blocked (i.e. some viruses) this 'inside-out' signaling axis is still functional?

[AndreasAufschnaiter @whateveroptosis]

@Interferon_G @jkagan1 so if I were a virus, targeting such motivs would help me dampening the interferon response? is there anything known in that direction? I know that VSV's (and other) M proteins block nuclear translocation of stuff, which would have similar outcomes I guess..

[@binningsingletons.com on bluesky @BSingletons]

I’m BEGGING people presenting data at #ASMicrobe (and everywhere, honestly) to consider colorblind individuals when making figures
Many of us can’t tell apart the colors being used
Accessibility matters
(I have no idea if there is a number in this image or not)

[Garcia Saez Lab @GarciaSaez_Lab]

Finally out! Unsaturated lipids regulate the growth of the apoptotic pore 🍩 @ShashankDadsena @CECAD_ https://t.co/WlqCPzEncs

[Villunger Lab @villunger]

Happy tho share Gerlinde Karbon’s PhD work on the drastic consequences of chronic SAC activation in vivo. Thanks also to the great support by the Foijer lab @UMCG_ERIBA and R. Sotillo @DKFZ, @imed_tweets, and all involved at MUI and CeMM @CeMM_News

https://t.co/3VYkbeuJzP

[Gianmaria Liccardi @Giammy_L]

Incredibly proud of our first paper in @cddpress on pMLKL-s345 . Congrats @c_kelep for driving this project. BIG Thank you to all our collaborators @ale_annibaldi81 @Linkermann_Lab @Walczak_Lab @PardoGalvez_Lab for your incredible support and input. https://t.co/DwjxyeCIId