Cell death enthusiast. MSc molecular medicine, atm persuing PhD on oncolytic viruses in Innsbruck AUT🇦🇹. Ferroptosis believer. Not too bad at sports climbing.
the landscape of cell death is online! Spent half a year in Seattle, WA in Andrew Oberst's lab, where we came up with a new way to conceptualize cell death commitment, similar to Waddington's famous landscape of lineage commitment! Thanks TJ and Andrew! #celldeath (free access👇)
So happy to see this in print: https://t.co/IhiBI99iAF
We show that B cells have extra centrioles during some developmental stages and that centriole loss arrests B cell development at this stage! 🥳 @NatureComms@villunger@AHollandLab
Hey Halloween fans, check out our latest paper! We’re diving into the fascinating world of the PIDDosome and how it activates the hitman Caspase-2 to kill cells that fail cytokinesis. Guess what? Caspase-2’s secret weapons are BID and p53! https://t.co/apml0F0uEW
1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in @ScienceMagazine.
https://t.co/yPDqKmpGnn
Here is a summary of what we discovered!
@Interferon_G@jkagan1 just read your paper https://t.co/PdBa4nkzRe !! fascinating mechanism! reminds me of RHIM- or DD-dependent oligomerization (and subsequent effects) during cell death..
@Interferon_G@jkagan1 if one would have some money left over, one could set up a crispr screen targeting pLxIS motivs, and measure IFN response &antiviral states after infection, right? but I guess also in steady states where there's always some base level of endogenous triggers of immune receptors..
@Interferon_G@jkagan1@Interferon_G interesting! Are you suggesting that there might be some kind of feedback or interplay from PRRs ("in") to the proteasome/Golgi/MHC ("out")? so that in cases where nuclear transport is blocked (i.e. some viruses) this 'inside-out' signaling axis is still functional?
@Interferon_G@jkagan1 so if I were a virus, targeting such motivs would help me dampening the interferon response? is there anything known in that direction? I know that VSV's (and other) M proteins block nuclear translocation of stuff, which would have similar outcomes I guess..
I’m BEGGING people presenting data at #ASMicrobe (and everywhere, honestly) to consider colorblind individuals when making figures
Many of us can’t tell apart the colors being used
Accessibility matters
(I have no idea if there is a number in this image or not)
Happy tho share Gerlinde Karbon’s PhD work on the drastic consequences of chronic SAC activation in vivo. Thanks also to the great support by the Foijer lab @UMCG_ERIBA and R. Sotillo @DKFZ, @imed_tweets, and all involved at MUI and CeMM @CeMM_News
https://t.co/3VYkbeuJzP