Jon Hoskins

Interested in Memes, Finance, Space, AI, Biotech, and the answers to the Universe.

[Jon Hoskins @ArgentariusJon]

@ideapharma Would it be fair to say that many of these are failing because their initial design is simply focused on getting through the next phase rather than having a high degree of confidence in phase 3 to begin with?

[Jon Hoskins @ArgentariusJon]

@Nicole_Paulk @matthewherper @ethanjweiss @AnthropicAI @DarioAmodei @lotte_bjerre @rickberke same lol

[Jon Hoskins @ArgentariusJon]

@ElliotHershberg I think you might be interested in @GatcHealth - lower x presence but here’s a good recap of what we’re doing

https://t.co/6O9Y4paEAj

[Jon Hoskins @ArgentariusJon]

@patricksmalone How about we starting insuring the outcome of clinical trials.

[Jon Hoskins @ArgentariusJon]

@LocasaleLab She's missing the main shift that will allow so much progress. Biology is shifting from a science problem to a tech problem.

I imagine that regulatory hurdles will be the biggest bottleneck and if we don't adapt and improve regulatory processes, development will shift overseas.

[Jon Hoskins @ArgentariusJon]

@elonmusk @t_blom Can we get an option to stay in or prioritize carpool/fastrak?

FSD constantly tries to leave those lanes. My thought- FSD that it believes it is a passing lane.

[Jon Hoskins @ArgentariusJon]

@kaoutharlbiati @statnews Predictive biological outcome platforms that will create safer more effective drugs will likely reduce how we measure an implement clinical trials in the future.

I see it revolutionizing drug safety the same way crash software revolutionized car safety.

[Jon Hoskins @ArgentariusJon]

@PeterDiamandis I faster path to approval and to safer more effective drugs will likely come from a platform that is able to successfully derisk the clinical trial phases with predictive outcomes.

[Jon Hoskins @ArgentariusJon]

@bryan_johnson Sounds like you need a co-sleeping protocol to test out the disputed science.

[Jon Hoskins @ArgentariusJon]

@marcuslemonis @NYCMayor Society’s wealth inequality clearly shows a dysfunctional tax system.

Yes the uber wealthy should be paying more tax.
Lawmakers should be held accountable for the pervasive and negligent spending.

Individuals should not pay tax on gross while business pay tax on net income

[Jon Hoskins @ArgentariusJon]

@zGuz Flipping is no different than scalping change my mind.

[Jon Hoskins @ArgentariusJon]

@marty_kausas I have an interesting idea.

What if company did a hard stop at 150 seats. If an employee wants one, they prove they’re worthy of the allocation.

Do the few extra seats justify the cost rise?

The team members who don’t make the cut uses another option.

[Robert Scoble @Scobleizer]

"Misanthropic."

I've never seen the AI community so angry at a major new model release. I asked my AI (an agent that @blevlabs made for me) to gather all the backlash.

+++++++++++

THE BACKLASH AGAINST CLAUDE FABLE 5'S RESTRICTIONS

The best analysis of why this matters:

@EnoReyes — "It's about who gets to decide, and whether you ever find out when they do. Fable won't fall back to a different model and tell you. It just limits the output through prompt modification, steering vectors, or PEFT. You won't be told when it happens to you."
https://t.co/k6s7gdgckk

THE VIRAL TAKE:

@0xBalloonLover — "anthropic won't let you use fable for biology, chemistry, ai research, or anything that accelerates human progress. that makes it the perfect tool for developing blockchains"
https://t.co/8GiTfZOASu

POWER CONCENTRATION:

@ClementDelangue (HuggingFace CEO) — "Concentration of power, capabilities and economic wealth is the biggest risk in AI. We need open science and open-source more than ever!"
https://t.co/6n4mjoCdfN

@jeremyphoward (https://t.co/hxyqsLY2ti) — "Anthropic has chosen the opposite of the safe path: they are allowing themselves, the current top lab, to use their top model for frontier AI research. They've said they'll sabotage others who try."
https://t.co/305uPAbiaA

@gneubig (Graham Neubig, CMU) — "First they came for the model builders... I feel we're getting a glimpse of a future where AI is only provided to a privileged few, and that's not a future I want to live in."
https://t.co/JiFiz55YYK

OPEN RESEARCH:

@askalphaxiv (AlphaXiv open science) — "As believers of open research, we are disappointed to see Anthropic silently degrading Fable 5 for AI development."
https://t.co/KaP0NEivW6

@willccbb — "it is the first publicly available model that i am explicitly not allowed to use for my work, because anthropic holds the view that the work i do to facilitate open model research is harmful. capability and alignment research are coupled. anthropic wants to be the only lab."
https://t.co/mIovN3a0FS

NOUSRESEARCH / HERMES (which Anthropic has nerfed multiple times):

@Teknium (NousResearch co-founder) — "What's crazy to me is that Fable is blocked from life sciences broadly, nerfed even if you get passed the classifiers and filter level blocks. The whole point of AGI/ASI is to cure all diseases. Everything else is just nice to haves. But Anthropic wants to close off that path."
https://t.co/8Nh5Squ2UA

THE MECHANISM:

@kimmonismus — "When the model is used for frontier LLM development, it apparently does not simply refuse or warn the user. Instead, it quietly limits its own effectiveness through techniques like prompt modification, steering vectors, and PEFT."
https://t.co/HsrA8xeScP

MEDICAL COMMUNITY:

@DeryaTR (immunologist, BSL-3 certified) — "The word 'cancer' is flagged as a biosecurity risk by Claude Fable 5! I also tried to code a website on cancer mutations & Fable 5 was immediately removed from my list!"
https://t.co/3VpiYWZmbz

@DeryaTR — "I can't even say 'hello' to Fable 5 except in incognito mode (memories off), because it knows I am a biomedical researcher!"
https://t.co/jxWcx8y8QE

@DeryaTR — "I am not even allowed to use Fable 5 with memories on! Apparently the model thinks I am a biosecurity risk, though I had been certified to work in biosecurity level 3 labs! Not a single Anthropic person has tried to reach out to help either!"
https://t.co/Rj6EGLw8Vq

@banteg — "claude fable 5 refuses completely benign tasks like analyzing bloodwork."
https://t.co/Wg5LLYK5lW

@bneyshabur — "Working on AI for cancer? Sorry, I can't help you. Working on AI for Alzheimer's Disease? Sorry, I'm becoming a bit dumb when it comes to the AI part of it."
https://t.co/wLetowldAD

SUBSCRIPTION CANCELLED:

@bubbleboi — "Have canceled my team subscription for Claude Pro. Idc how good that model is, it's not good enough for me to support people who actively stifle innovation and gate keep knowledge that they didn't even create."
https://t.co/4km3iR3N12

BILLING AND PRIVACY:

@GergelyOrosz (The Pragmatic Engineer) — "Things I really dislike about Fable: 1. Anthropic collects my prompt history, stores it, and does whatever they want with it for 30 days. No opt-out. 2. They can nerf their most expensive model without telling me, billing me the same amount, wasting my time. Whenever they want."
https://t.co/pV5qiZnsTR

THE KARPATHY QUESTION:

@SanthProject — "the old @karpathy would never support a company that fucks other llm researchers. Were the stock benefits that good?"
https://t.co/Hw8uHLuZWB

THE MONOPOLY CHARGE:

@tunguz (TabulAI founder) — "Starting to suspect that Anthropic's putative security and safety considerations are largely posturing and performative."
https://t.co/gwKrgbNSWY

@BlancheMinerva — "Anthropic is choosing to make decisions that make the world a significantly worse and potentially more dangerous place."
https://t.co/Tlc6ct64AH

@LinusMixson — "Dario personally, and Anthropic as a whole, have been extremely straightforward about wanting a monopoly for a long, long time."
https://t.co/Ngj9csOazh

@TheAhmadOsman — "I started warning people about Anthropic more than a year ago... Today I am vindicated, everybody knows that company only acts in bad faith."
https://t.co/l0TmVRJOSO

WHY REGULAR PEOPLE WILL EVENTUALLY CARE:

@DanJeffries1 — "The fury is real and what all of us in the open community have been saying for years and yet regular folks don't get it yet because nothing they care about is restricted or taken away for 'safety.' They will care a LOT in the future when AI is integrated into every aspect of [life]."
https://t.co/W0BgfgkOqd

Full analysis: https://t.co/8L5xphk0qQ

[Jon Hoskins @ArgentariusJon]

@edgecase411 @CamCutApp While I think FSD could have done a better job braking and creating more distance, the van in front of your dad had a significant change in the velocity of his deceleration and came to a sudden stop.
It looks like the van slammed on his brakes as well.

[Jon Hoskins @ArgentariusJon]

@GazzettaFerrari This exactly, do the car under a new brand name.

[Jon Hoskins @ArgentariusJon]

@RippleXrpie Remember when the government said you should get an adjustable rate rate loan to save money on your monthly house payment...

[Jon Hoskins @ArgentariusJon]

@elonmusk How can we solve the government leadership problem.

We need a way to incentivize good effective government leadership while also ensuring that there is a direct personal and/or financial loss to be had for poor leadership.

We currently reward bad leadership!

[Jon Hoskins @ArgentariusJon]

@PeterDiamandis It’s not abundance that will be the issue it will be how that abundance is hoarded or controlled.

How do we ensure excessive greed and thirst for power by a select few with means,doesn’t prevent that abundance from being withheld from others?

[Jon Hoskins @ArgentariusJon]

@CAgovernor It could be a $50 trillion global power house for all care. It’s still failing most Californians!

[Jon Hoskins @ArgentariusJon]

@imPenny2x This is all very true but don’t underestimate the ability of a few to still find ways to capture that power.

It is not lack of abundance that is a concern but human nature.

The world of abundance will also create privately owned robotic armies.