Chris Mesnard, Ph.D. 🧠

Neuroscientist interested in synaptic transmission and mitochondrial dysfunction. Former Corpsman, 3rd Battalion, 3rd Marines. Jiu Jitsu Black Belt 🥋

[Chris Mesnard, Ph.D. 🧠 @CS_Mesnard]

Just published “Synaptotagmins 1 and 7 in vesicle release from rods of mouse retina” after a very long and tedious road of breeding to obtain genetic crosses in which Syt1, Syt7, or both, were eliminated in rods, or cones, or both. It’s finally here!

https://t.co/Y0izBASftz

[Chris Mesnard, Ph.D. 🧠 @CS_Mesnard]

@bryan_johnson Just now wondering this?

[Chris Mesnard, Ph.D. 🧠 @CS_Mesnard]

@SenMullin @POTUS @SenateGOP @WhiteHouse @DOWResponse You have to have an IQ to debunk something.

[Chris Mesnard, Ph.D. 🧠 @CS_Mesnard]

@SenMullin You just said a lot of really dumb nonsense that is on par with someone that went to a bottom-feeding high school and then quit “learning. You’re a pussy. A big, dumb pussy.

[Chris Mesnard, Ph.D. 🧠 @CS_Mesnard]

@PeteHegseth Pussy.

[Michael Snyder, PhD @SnyderShot]

Our aging paper just came out. Two periods of major changes: Mid 40s and 60s. Check it out https://t.co/k2qyHJPiq7

[Björn Schumacher @schumacherbj]

🔥🔥🔥my 💯 paper is out, congrats 🎈🎉🍾 @Meyer_DH for this amazing story. Aging clocks tick by the noise: we can build aging clocks 🕰️ on accumulating stochastic variation! @CECAD_ @UniCologne @CGA_age @UKKoeln follow 🧵retweet & read now open access: https://t.co/x3sCZoYkKP

[Charles Brenner, PhD @CharlesMBrenner]

good video w some caveats:

though sir2 overexpression extends replicative lifespan, this only benefits 1 in 5 million yeast cells

sir2 opposes lifespan in yeast & in flies--this means that the sir2 target itself doesn't make sense as something we're trying to increase in aging

[Charles Brenner, PhD @CharlesMBrenner]

in my review on sirtuins, i documented how very weak primary research papers were amplified by an uncritical press & then codified into accepted wisdom by irreproducible primary papers & gushing review articles that went well beyond any specific result

https://t.co/qZcQuu4FGw

[Rava Azeredo da Silveira @Rava_daSilveira]

Applications are open for the CNeuro2024 summer school in computational neuroscience to be held in Beijing, 8-15 July 2024. Rolling admissions starting March 1. See https://t.co/5aaVG2zQdZ for details on program and application process.

[Jon Soucy @jrsoucy]

Very excited to share our recent work to improve cell replacement therapies for restoring vision lost to glaucoma and other optic neuropathies! @BaranovLab @Levi_J_Todd @HMSeye @MassEyeAndEar

https://t.co/LXu9PsZom6

[Layne Norton, PhD @BioLayne]

The average caloric intake in the USA: 3540 kcal/day

The average daily physical activity: less than 20 min

But there are people out there who believe oatmeal, fruits, vegetables, & polyunsaturated fats are what is making us sick

[Dan Goodman @neuralreckoning]

I'm happy to announce the start of a new free and open online course on neuroscience for people with a machine learning or similar background, co-developed by @MarcusGhosh. YouTube Videos and Jupyter-based exercises will be released weekly. There is a Discord for discussions.

[Ian Weissman, DO @DrIanWeissman]

Dr. Katalin Karikó, who is sharing the Nobel Prize in medicine for her work with mRNA vaccines, says she was previously demoted by the University of Pennsylvania for her research in this area because she could not secure research funding.
https://t.co/mILBCwexiw

[FrezzaLab @FrezzaLab]

congrats @AKohler_Mito
@Ott_MitoLab
and @langer really cool work

Early fate decision for mitochondrially encoded proteins by a molecular triage: Molecular Cell https://t.co/uNopA6boJG

[Kirill Martemyanov Lab @KLabGPCR]

Our systematic investigation of G protein coupling profiles of 100+ #GPCRs driven by the one and only Ikuo Masuho is out after ~10 years of work. We see many interesting patterns with the help of AI. Check it out- there is a useful reference table.
https://t.co/ia0BIfjuii

[David Pla-Martín @Dpla_]

Impressive work led by @mitodynamics. Congrats to the team!
A mechanistic view of mtDNA transfer to endosomes
https://t.co/bS55RziTqF

[David Pla-Martín @Dpla_]

Have you ever wondered why mtDNA is maternally inherited? These guys found the answer! Because of TFAM!!! . Check out!

https://t.co/OGAdo7UtzQ

[nature @Nature]

Psychedelics reset the brain to a youthful state in which it can easily absorb new information and form crucial connections between neurons, a study in mice suggests. https://t.co/WjMlAEHTBc

[Elena Berezhnaya @Elena_Berezhn]

Enhanced mitochondrial buffering prevents Ca2+ overload in naked mole‐rat brain - Cheng - The Journal of Physiology - Wiley Online Library https://t.co/vXISiD4wb1

[Natalie Gukasyan, MD @N_Gukasyan]

Results from our multi-site study of psilocybin-assisted therapy for MDD are live today in @JAMA_current. Psilocybin had about a 12 point MADRS advantage over niacin control at day 8 that appeared durable through 6 wk follow-up. https://t.co/oUIE9ZhplV 1/