Colbie Chinowsky, PhD 🔬🌈

PhD Cell Biology, BA Physics | R&D for @oniHQ | Actin protrusions, myosins, #scipol, #LGBTQinSTEM | @MountHolyoke @VanderbiltU alum | Opinions my own.

[James Zou @james_y_zou]

🌹Meet #ROSIE, our new AI that predicts spatial multi-protein expression straight from routine H&E images.

Built on a large co‑staining dataset (>1k samples, 16M+ cells). It enables cell phenotyping & tissue structure insights w/o extra assays.

[Jason Spence @TheSpenceLab]

Excited to share our latest preprint led by Kelli Johnson- Mapping mesenchymal diversity in the developing human intestine and organoids!

We defined 5 mesenchymal populations occupying discrete anatomical locations within the human intestine.
https://t.co/rzSfsdGhjO

[eLife - the journal @eLife]

🧠🔬 A new microscope, ExA-SPIM, lets researchers zoom from molecules to whole brains, no slicing required.

By combining tissue expansion with high-speed imaging, it captures stunning detail across entire mouse brains and even human samples.
https://t.co/JAdHwumc9W

[MIMETAS @MIMETAS_3D]

Together with sanofi, we developed a human immunocompetent kidney-on-a-chip model to study renal inflammation. This tri-culture system enables immune cell migration tracking & drug testing in a 3D flow environment.
📖 Read more: https://t.co/Q8v0gbhfjU
#OrganOnChip #CKD

[Arc Institute @arcinstitute]

Introducing Arc Institute’s first virtual cell model: STATE

[Timothy Caulfield @CaulfieldTim]

Yep.

The hidden elitism of RFK's MAHA movement is making America more unhealthy https://t.co/0yh7Fnw9Jb by @AmandaMarcotte via @Salon

"He's taking away health care, with a special emphasis on limiting access for women, minorities, children, & working people."

[Denis Wirtz @deniswirtz]

We introduce InterpolAI, an optical flow-based AI model to enhance 3D imaging (MRI, CODA, ssTEM, light sheet)

Read about it here in our new NM paper: https://t.co/LIpzl3heoB

[Vanderbilt School of Medicine Basic Sciences @VUBasicSciences]

🎉 Congratulations to @VanderbiltBrain director @LisaMonteggia and @VUCellImaging director Matthew Tyska on being named 2024 @AAAS Fellows! 🏅 Their exceptional contributions to #neuroscience and #cellbiology have earned them this prestigious recognition. https://t.co/9Ap0JunaOp

[Michael Baym @baym]

Terminating unrelated biomedical research grants because of political accusations before any kind of investigation or due process is an obscene authoritarian move that in addition to being unamerican, will weaken America permanently

[Nikon Microscope Solutions @NikonInst]

A recent article details an unsupervised Bayesian approach to reconstructing #SuperResolution structured illumination #Microscopy #SIM images that better models noise, maximizing recoverable resolution across a range of signal-to-noise levels: https://t.co/9VeVA0HYvf

[Erin Gibson @ErinMGibson]

Exclusive: NIH appears to archive policy requiring female animals in studies | The Transmitter: Neuroscience News and Perspectives https://t.co/1YuR8Opc6f

[Elliot Hershberg @ElliotHershberg]

Gene therapy restores hearing (!!)

This is the goal. Beautiful mechanistic therapies with effect sizes so big that they can be seen in the very first dozen patients dosed.

Congrats to the one and only Steve Holtzman and the Decibel team for establishing this program, and to Regeneron for carrying it forward.

[nature @Nature]

About a month after Donald Trump took office as the 47th US president, almost all grant-review meetings remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.

https://t.co/ly8mKijdtQ

[Zachary Sanchez @EntoSanchez]

Happy #FluorescenceFriday ! Today is an exciting day because I can finally share data from my thesis work. Below is a gif of a blebbisome, a new large extracellular vesicle that I describe and characterize in collaboration with the Coffey Lab. https://t.co/u1tUtyjxyR

[Olivier George @brainaddiction]

It's clear that many do not understand what @NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment

Every single new drug approved by the FDA from 2010–2016 was built on NIH-funded research—that’s all 210 drugs. But what the public sees is just the tip of the iceberg.

Pharma takes credit for the final product, but beneath each drug developed, there are ~20 years of basic research, and 90% of the cost is from basic research funded by the NIH, which discovers drug targets, understands disease mechanisms, and creates life-saving treatments.

Figuring out how cancer evades the immune system, how addiction rewires the brain, and how heart disease develops is the role of the NIH, creating the foundation for the breakthrough drugs that come 20 years later, and the NIH does all that with only 0.8% of the US budget.

Without NIH, there would be no cancer immunotherapy, no anti-overdose medication, no anti-heart attack or stroke medication, no cutting-edge treatments.

If NIH funding is cut, the iceberg will melt. That means fewer cures, more suffering, and more lives lost.

The science beneath the surface keeps us afloat.
Invest in NIH. Invest in life

[Daniel Kraft, MD @daniel_kraft]

@Farzad_MD CDC cuts expected to devastate Epidemic Intelligence Service, a ‘crown jewel’ of #PublicHealth

https://t.co/mfPXx8salA

[Biomedical Picture of the Day BPoD @BPoD_s]

New approach with an unmixing algorithm & 8-channel image acquisition enables multispectral live-cell imaging

📷: @_Akaash_Kumar et al @JamesDManton @MRC_LMB in @biorxivpreprint
➡️: https://t.co/JUIeaGLnHh with @AntDLewis

[BowTiedBiotech 🧪🔬🧬 @BowTiedBiotech]

1/ THREAD: Where do mRNA vaccines go after injection?

Lipid nanoparticles (LNPs) are the workhorses of mRNA vaccines, but how do they move through the body?

New PET-CT imaging in rhesus macaques gives us answers. 🧵👇

[Colbie Chinowsky, PhD 🔬🌈 @DrChinowsky]

🤩🤩

[ONI @oniHQ]

The time is now. A new era of super-resolution imaging has arrived. Meet Aplo Scope – ONI's new #singlemolecule #superresolution microscope designed for effortless #molecular imaging.

Learn more - https://t.co/8tHaTrXQ9B
Webinar (January 30) - https://t.co/FRA64rrM66

[Nikon Microscope Solutions @NikonInst]

A recent review article explores fluorescent labeling systems for #SuperResolution #Microscopy of cellular membranes, including lipophilic and click chemistry-based lipid-like dyes compatible with expansion microscopy #ExM: https://t.co/aaKaKwkJcJ