Eran Shorer

MD MSc - UCT
Computational Neuroimmunology Postdoc - JHU
Current Neurology resident - Mount Sinai West

[Eran Segal @segal_eran]

Our new @NatureAging paper: We built 14 "biological clocks" representing the biological age and rate of aging of 14 major body systems using data from 13,000 people of the Human Phenotype Project

Key findings:

1. Biological clocks are clinically meaningful: People with higher biological age for some body system are at greater risk for disease related to that body system (e.g., higher aging rate of insulin resistance associates with higher risk for diabetes)

2. Surprisingly, biological clocks for different body systems are mostly independent, i.e., a person with a higher rate of aging for one body system does not necessarily have higher aging rates in other body systems

3. Males and females age differently: While males age linearly, females exhibit a sharp non-linear increase between the ages 50-55. This sharp increase is associated with menopause. When comparing pre- and post-menopausal females of the same chronological age, we find that post-menopausal females have higher biological age for several body systems

Paper: https://t.co/RWfQ1mfMYV
Data: https://t.co/qRrFPaY4as
Access our aging models: https://t.co/3do2rlTgQV

Great job by @Lee_Reicher1, @NoamBar7, @nastya_godneva, Yotam Reisner, @ZahaviLiron, Nir Shahaf, @AdinaBlueBird, in collaboration with Raja Dhir

[Kira Düsterwald @kiradusterwald]

Exciting to see this out after working on the modelling with @EranShorer! 🌸 ORCHID = all-Optical Reporting of CHloride Ion Driving force & uses voltage imaging with a Cl-permeable channel to evaluate inhibitory transmission in neurons. Epic effort @joshsselfe & @JosephRaimondo!

[Eran Shorer @EranShorer]

Awesome work by all involved here, what an incredible project to be apart of

[Josh Selfe @joshsselfe]

Ever wanted to explore the driving forces underlying inhibitory neuronal signalling? We did! So, for my MSc in @JosephRaimondo lab, we developed the all-optical approach ORCHID - all-Optical Reporting of CHloride Ion Driving force. Now out in @NatureComms https://t.co/kJGv5mZkpg

[Steven Strogatz @stevenstrogatz]

For anyone curious about nonlinear dynamics and chaos, including students taking a first course in the subject: My lectures are freely available here. https://t.co/y5n3S9nXCx

[Mark Lewis, MD, FASCO @marklewismd]

Incredible tribute to phospholipids

[Neuromatch @neuromatch]

Exciting news! Neuromatch seeks a new CEO/Executive Director! We are so grateful to @Nick_Halper for his brilliant leadership, and now it has come time to pass the torch to someone new for our next phase of programming and growth! Please share widely! https://t.co/9I9pL2JbGt

[Allen Downey @AllenDowney]

On Reddit's statistics forum, the most common question is "What test should I use?"
My answer, from 2011, is "There is only one test"

https://t.co/J5Ar4olekz

[Eran Shorer @EranShorer]

Incredible work Oded and co.

[Oded Rechavi @OdedRechavi]

It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇
https://t.co/I2j2pAel69

[NEJM @NEJM]

In the PURPOSE 1 randomized, controlled trial involving women in South Africa & Uganda, twice-yearly subcutaneous lenacapavir was superior to daily oral emtricitabine–tenofovir disoproxil fumarate in preventing HIV infection. Full trial results: https://t.co/MMqEYZpszL

#AIDS2024

[IAC - the International AIDS Conference @AIDS_conference]

👏 @DTHF_SA’s @LindaGailBekker 🇿🇦 receives a standing ovation after presenting full results from the PURPOSE 1 study. The results confirm #lenacapavir demonstrated 100% efficacy for #HIV prevention in cisgender women.

[Johns Hopkins Neurosurgery @HopkinsNsurg]

Congrats to Raj Mukherjee @NeuroOncSurgery for performing the 1st @HopkinsMedicine glioma brain tumor resection using 5-ALA @HopkinsBayview. 5-ALA is an optical imaging agent that turns tumor cells bright pink during fluorescence-guided surgery making it easier for resection

[Kira Düsterwald @kiradusterwald]

Interested in the intersection of neuroscience and AI? It's your last chance to apply to the computational neuro Imbizo in South Africa in January! Apps close on Wednesday: https://t.co/buffcH20ca

[Johns Hopkins University @JohnsHopkins]

Beginning in the fall of 2024, Johns Hopkins University will provide tuition-free Medical School for most medical students and expand aid for future nurses and public health pioneers. Learn more: https://t.co/QuBluT7CWo

[Eran Shorer @EranShorer]

I feel so fortunate to have been educated by this incredible clinician-scientist. Best of luck in your new role @ntobekon!

[SAMRC @MRCza]

South African Medical Research Council welcomes new President and CEO. The Board of the South African Medical Research Council and its staff are excited to welcome Professor Ntobeko Ntusi as the new President and Chief Executive Officer of the SAMRC. https://t.co/bbtoDeza6c

[SAMRC @MRCza]

South African Medical Research Council welcomes new President and CEO. The Board of the South African Medical Research Council and its staff are excited to welcome Professor Ntobeko Ntusi as the new President and Chief Executive Officer of the SAMRC. https://t.co/bbtoDeza6c

[Amy Maxmen, PhD @amymaxmen]

As childhood vaccines exemptions hit their highest level on record, worth sharing this A+ graphic on the risk from measles v risk of vaccines.

The lifetime risk of getting killed by lightning in the US is 4x greater than an allergic rxn to MMR vaccine.

[Eran Shorer @EranShorer]

Huge congrats to Liz Marsh and the whole team @HopkinsMarshLab 👏👏👏

[The Marsh Lab at Johns Hopkins @HopkinsMarshLab]

Thank you @TIME for the feature in 2024's Woman of Impact! So honored to be mentioned and continue working to spread awareness and advance the recovery for stroke patients nationally.

[Marom Bikson @MaromBikson]

@elonmusk @neuralink What Silicon Valley needs to know about the brain, and what it doesn't:
https://t.co/dEBlibD2UI

[murat 🍥 @mayfer]

i'll never get over how the cochlea is an analog fourier transform organ

[SAMRC @MRCza]

The SAMRC is thrilled to announce the appointment of Prof Ntobeko Ntusi as its new President & CEO, effective 1 July 2024. Prof Ntusi will succeed the esteemed Prof Glenda Gray, who has been the SAMRC President for the past ten years. https://t.co/OVQi2Ni20z