Feilin Liu, MD, PhD

Instructor @MayoClinic | Neurology, Neuroscience, Proteomics 🔬🧠ALS/FTD

[JAMA Neurology @JAMANeuro]

This JAMA Neurology #Review proposes #TDP43-associated #neurodegenerative disease as a staging framework that links presymptomatic biology with later clinical phenotypes and could support earlier mechanism-based treatment development.

https://t.co/Aw6XXHzPtN

[NEJM @NEJM]

Inflammatory myopathies are typically associated with a myositis-specific autoantibody that determines the diagnosis and prognosis. Myositis subgroups have distinct pathomechanisms that now allow for targeted therapies.

Learn more in the Review Article “Inflammatory Myopathies” by Yves Allenbach, MD, PhD, and Olivier Benveniste, MD, PhD: https://t.co/ZeCKdNe87v

[JAMA Neurology @JAMANeuro]

From JAMA: Amyotrophic lateral sclerosis (#ALS) is an adult-onset neurodegenerative disorder characterized by progressive muscle weakness due to degeneration of upper motor neurons in the brain and lower motor neurons in the brainstem and spinal cord.

https://t.co/VvFlo5RKbX

[NEJM @NEJM]

Presented at #SVIN25:

CREST-2: In high-grade asymptomatic carotid stenosis, addition of stenting to medical therapy led to a lower risk of stroke over a 4-year period. Endarterectomy did not lead to a significant benefit. Full results: https://t.co/ojge1CjqiU

Editorial: Managing Asymptomatic Carotid Stenosis https://t.co/D9LH89Edyk

@svinsociety

[Lea Alhilali, MD @teachplaygrub]

If you aren’t cheating, you aren’t trying!

Are you looking at MRIs?

Feeling some confusion about the diffusion?

Feel impaired when it comes to the FLAIR?

Wish you could cheat a little?

Here’s a post to help you cheat on all the sequences you NEED to know if you are looking at MRIs!

--T1: It’s for anatomy, so brain structures reflect the same color as real life. So gray matter is gray on T1 & white matter is white on T1. It’s also for contrast. Contrast material is taken up by masses making them light up & them easier to see.

--T2: It’s the water sensitive sequence. What is pathologic water in the brain? Edema! My attending once said, “Everything bad in this world is trying to turn you back into what you came from—water."

-- DWI: Diffusion detects stroke, which are bright on diffusion. But anything that makes space tight in the brain can be bright on diffusion (highly cellular masses, clotted blood, pus under pressure, etc.)

--Gradient: Gradient is sensitive to metals. And what’s the most important metal in body? Iron—bc iron is in blood. So gradient is our blood sensitive sequence

So now you know the basic MRI sequences and what they are used for! Now you get rid of all pretenses when it comes to MR sequences!

[NEALS Consortium @NEALSConsortium]

It’s incredible to see how much the NEALS Annual Meeting has grown! Each year the room gets bigger, the conversations richer, and collaboration stronger!

Dinner, generously sponsored by @alsassociation was a perfect reminder of how far we’ve come together.
Thank you! #NEALS2025

[Feilin Liu, MD, PhD @FeilinLiu]

@BassellLab Congrats!! 🎉

[Wilfried Rossoll @RossollLab]

https://t.co/gYUWBuQC1B
Out now! Probe‑dependent Proximity Profiling (ProPPr) of Phospho‑Tau‑Associated Proteomes across Tauopathies by @DMorderer and @NeuroWren. Great collaboration with @DrNeuroChic and Dr. Dennis Dickson! @MayoClinicNeuro @MolNeuro @cziscience @NIHAging

[Feilin Liu, MD, PhD @FeilinLiu]

@LWang357 🥲

[Feilin Liu, MD, PhD @FeilinLiu]

Comet Tsuchinsha-ATLAS

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

[Feilin Liu, MD, PhD @FeilinLiu]

🪴 + 🐶 both inside
Ready for the hurricane 🌀

[Feilin Liu, MD, PhD @FeilinLiu]

@ZhaoNaa @ScienceAdvances @owenaross @shunsuke_koga @pamjmclean @TsuneyaIkezu @MayoClinicNeuro Congrats!!!!

[ShorterLab @ShorterLab]

CryoET of β-amyloid and tau within postmortem Alzheimer’s disease brain: https://t.co/lcsQYgSGku

[Feilin Liu, MD, PhD @FeilinLiu]

First day in Taipei!
Excited for the training with @IncSyncell

[Lea Alhilali, MD @teachplaygrub]

1/Having trouble remembering how to differentiate dementias on imaging?

Is looking at dementia PET scans one of your PET peeves?

Here’s a thread to show you how to remember the imaging findings in dementia & never forget!

[Feilin Liu, MD, PhD @FeilinLiu]

@DenisBalabanMD @MGHNeurology @BWHNeurology @GGheihmanMD Absolutely amazing experience! Love the $100 💵/ selfie 🤳 tricks😂! Highly recommend to anyone who wants to refresh their memory or gain a better understanding! 🤩

[Feilin Liu, MD, PhD @FeilinLiu]

@naomikouri Congrats Naomi!! Great work!!

[Feilin Liu, MD, PhD @FeilinLiu]

OK let’s admit it:
EMG is SO COOL!!
“sounds like pour water into hot oil pan” “sounds like engine about to die” “sounds like the popcorn when the first kernels start to pop”
Hahaha love it!!😂

[Feilin Liu, MD, PhD @FeilinLiu]

Day2 at #AANAM
Love the combination of snow mountains and reflection of the skyscrapers 🏔️🏙️