Harsha Garadi Suresh

Postdoctoral fellow interested in Ubiquitin Proteasome System at Donnelly Centre of University of Toronto. Formerly at University of Heidelberg.

[Ivan Đikić @iDikic2]

Many thx to all organisers of #TPDfocus in Dundee. It was one of the best meeting I attended in many years. Science, fun, style, kindness, smiles, quality and SUN for three days
All was there to celebrate opening of @UoDCeTPD

[Frydman Lab @FrydmanLab]

We are proud and excited to share the new study from our lab, led by the amazing @RanenAviner. It uncovers an important pathogenic mechanism causing cellular dysfunction in Huntington's Disease. We hope this work will inspire new and effective therapies
https://t.co/WS4o1BwUw6

[Mikko Taipale @mike_tilapia]

Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ https://t.co/vzNbJyR2rk https://t.co/5S9i7UG7JL

[Molecular Cell @MolecularCell]

Online Now: Transcriptional reprogramming at the intersection of the heat shock response and proteostasis https://t.co/KjzHjirjdN

[Gladfelter Lab @GladfelterLab]

Excited to share our recent preprint examining how fungi can adapt to different climates via small changes in the sequence of condensate forming proteins: https://t.co/hZ82ggmu8X

[Feng Zhang @zhangf]

Thrilled to announce our latest exploration of CRISPR! By developing an advanced algorithm, we’ve analyzed 8 terabases of microbial data, leading to the discovery of over 200 novel CRISPR systems. Kudos to @altaetran and @soumya_kannan12 for their exceptional work! Details in the thread below:

[Andy Truman PhD @TrumanLab]

Please RT: We are seeking postdoc applicants to join us in studying the role of the Hsp70 chaperone code in cancer! See below for more info 😀

[gingraslab @gingraslab1]

I am excited to begin my new role as Director of the LTRI and @SinaiHealth VP Research! Lots of fantastic opportunities ahead. Today: we are hiring for 2 critical positions for the office: 1) Executive Assistant; 2) Scientific Communications Officer. Come join our team!!! 1/6

[Alice Ting @aliceyting]

TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase period (minutes to hours) and then 1-minute APEX tagging in the destination compartment. Proteins tagged by both enzymes are enriched with streptavidin and anti-fluorescein antibody, and identified by mass spec.

We explore 4 intracellular and intercellular applications of TransitID:
- discovery of locally translated mitochondrial proteins (translated at OMM, then imported into mito matrix)
- mapping proteins whose cytoplasm-to-nucleus shuttling is dampened by stress
- discovery of proteins that transit between nucleolus & stress granules during stress & stress recovery
- analysis of proteins that traffic intercellularly bw tumor cells & macrophages

Work of amazingly talented co-first authors @WeiQinChemBio and @CheahJoleen, and collaborators Steve Carr @namude & Paul Taylor

https://t.co/yo4laOA14z

[Natali Fili @NataliFili]

Our daughter has been diagnosed with this rare brain cancer, DIPG. Due to its rarity, available data and treatment options are limited! Please retweet and If you are aware of any trials, please get in touch! Thank you!

[Harsha Garadi Suresh @GaradiSuresh]

@iDikic2 @IBC2_GU @goetheuni @HMWK_Hessen @sfb1177 @EnableFrankfurt @proxidrugs @RMU_EMTHERA @Angela_Dorn @FCI_health Congratulations, Ivan!

[Bukau Lab @BukauLab]

Great news! Together with @sjtans & @The_Ban_Lab, we are among this year's recipients of a Synergy Grant from @ERC_Research. This marks the beginning of an exciting journey into a mechanistic analysis of the biogenesis of protein complexes 🧬

[Harsha Garadi Suresh @GaradiSuresh]

@BukauLab @sjtans @The_Ban_Lab @ERC_Research Many congratulations to the entire team! Some great science to look forward to!!!

[Medenbachlab @medenbachlab]

Interested in establishing ribosome profiling in your lab? Check out our easy-to-implement and rapid protocol for low input samples: https://t.co/aCJjb2LkCF
#ribosome #RibosomeProfiling #RiboSeq #RNAsequencing

[Journal of Cell Biology @JCellBiol]

Shrivastava, Mogk, Bukau @BukauLab et al. @ZmbhH demonstrate that the function of sHsp sequestrase is evolutionarily conserved and based on specific sequence features of their disordered N-terminal extensions. https://t.co/FHNYoubgxG

@declan_c9
#Biochemistry #ProteinHomeostasis

[Mizushima Lab (UTokyo) @MizLabUT]

Our new paper is out in @MolecularCell !! We found phosphatidylethanolamine is ubiquitinated!! Congratulatioons Jun-ichi!!
https://t.co/xFiDJHT1qr

[Mikko Taipale @mike_tilapia]

Our latest manuscript is in bioRxiv! This project was huge effort by @JulinePoirson and Akash Dhillon in the lab and our first (but hopefully not last) foray into targeted protein degradation and stabilization. 1/ https://t.co/jreVQKObm7

[Rebecca Eccles @RLEccles]

Excited for our Focus Issue on Quality Control to finally be out- hope you enjoy reading it as much as we enjoyed putting it together! Thanks to all authors and reviewers!

[Donnelly Centre @DonnellyCentre]

Congratulations to our investigators Brenda Andrews, Charlie Boone, Gary Bader and Molly Shoichet for securing federal funding from @CIHR_IRSC to build maps of cellular function and explore new treatments for blindness!

Learn more: 👇
https://t.co/qP5atpdROm

[CBC Toronto @CBCToronto]

WATCH LIVE | Mayor John Tory provides an update after a major winter storm walloped Toronto on Jan. 17, 2022. https://t.co/SlH8OcXJfz