Greg Ngo

R-loops & Genome Stability Lab, @wellcometrust CDA fellow based at @CardiffUni

[Ross Chapman @Chapman_lab_UK]

Check out our latest, just out in @MolecularCell! We reveal how typically harmless forms of DNA damage synergise with DNA replication defects in ATM-deficient cells to drive cancer responses to PARP inhibitors—and propose that a similar synergy may contribute to A-T pathogenesis.

[James Pearson @JAPearsonLab]

Learn all about how we developed an interactive research activity and in person research event with young people living with T1D with the help of @britsocimm, @BT1DUK, @BioRadEducation kits, the Steve Morgan Foundation, and a team of fantastic people! https://t.co/HeO3rVR7TQ

[Fusion Conferences @Fusion_Conf]

#RecombMechanisms registration is open! 🎉
Join @SCWestLab as we bring together leaders in the fields of DNA recombination (both mitotic and meiotic), repair, replication, transcription, epigenetics, and cancer biology.
For more information, head to our website ➡️https://t.co/bXt3PasFRV

[Lisa Whittaker @LisaWhittaker02]

First post in a wee while - this weekend I’m running around in circles for 24 hours. I’ve already had very generous & kind donations, I’d love to raise a little bit more if possible🤞🏻all details below 👇🏻 ☺️ @BloodCUK_Wales @BloodCancer_Res @bloodcancer_uk
https://t.co/vq4dDxcLKY

[Greg Ngo @GregNgoHP]

🎓 Fully funded PhD studentship at Cardiff University!

Interested in DNA repair, genome stability, autism & ADHD? 🧬🧠

Join our lab to investigate how UPF3B mutations affect DNA repair and neuronal development.

Please share ! Thank you.

🔗 https://t.co/ObAb5LAkvH

[Fabrizio d'Adda di Fagagna @FdAdF66]

🚨 Can we kill a cell by targeting DNA that does nothing?

🧬 Our study shows Cas9 can selectively kill cells carrying a non-functional target sequence, sparing cells without it.

Weaponizing CRISPR/Cas9 for selective elimination of cells with an abe… https://t.co/s5Upaf1UgQ

[Greg Ngo @GregNgoHP]

Excited to share our new paper in @NatureComms!
Using #nanopore sequencing, we uncover how mitotic microhomology-mediated break-induced replication #MMBIR can generate #chromoanasynthesis linked to cancer and congenital disorders.
https://t.co/hXQSTlbEze

[James Pearson @JAPearsonLab]

Thank you @BreakthroughT1D for highlighting what we are doing in the #Type1DiabetesGrandChallenge. Our research aims to better understand both when best, and which, therapies to give those with/at risk of T1D to improve protection of those remaining insulin-making cells. 🔬

[Martijn Luijsterburg @luijsterburglab]

Great response so far for the DNA Repair Meeting in April 2026 ! 🧬

A few poster spots are still available.

✨ Early-bird registration extended to February 28th
✨ New invited speakers added: check the site: https://t.co/rpTTPiPVDD

Don’t miss this outstanding meeting!

[Martijn Luijsterburg @luijsterburglab]

Excited to share our new Nature study! 🧬

We (@UruciSidrit et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful co-directional clashes with DNA replication machinery. This protects cells from R-loops and genome instability.

https://t.co/oVshI7n2Mt

[Roger Greenberg @RogerRogergr]

Please see our review article in NSMB, “Mechanisms and genomic implications of BIR”. Adel Atari and @HaoyangJiang2 focus on mammalian BIR, its relationships to human disease, and genome engineering. Thanks to reviewers for helpful comments.

https://t.co/RHa74TmS2F

[Vincent Dion @VDion_and_Lab]

@CejkaLab Sorry: correct link is here:

https://t.co/kGZVfeh2Ia

[Cejka Lab @CejkaLab]

We are thrilled to present you our work on BRCA1-BARD1 @Nature showing that the complex has a direct role in long-range DNA end resection. With @CeppiIlaria @DelloStritto_MR and our collaborators @PabloHuertasLab @SylvieNoorderm1 and Seidel labs.

https://t.co/xh3J7mtwaV

[ChrisStaples @StaplesLab]

Please RT! 2-yr postdoc available in my lab here in Wales, studying post-replicative repair mechanisms in cancer cells. Salary £37kpa. Please DM for info or email [email protected] for informal chat. Closing date 31/12/23.
https://t.co/0eayQpWGZB

[Greg Ngo @GregNgoHP]

@alex_tonks @alanlparker Thank you Alex!

[Greg Ngo @GregNgoHP]

@alanlparker Thank you Alan!

[Alex Tonks @alex_tonks]

Grateful to @ResearchWales for funding our continued studies and to @BloodCancer_Res who funded the original study; quantitating nuclear proteomics in #AML. Thanks also to MediWales Review and Directory 2023 - Issuu for highlighting this
https://t.co/6jLgOtePnt 👇

[Dr Samuel Chawner @ChawnerSamuel]

New publication out on the impact of 22q11.2 Deletion Syndrome on early child development. In collaboration with @CNGGcardiff @neurosciencecu @bm_marianne @PsychCardiffUni @SchoolOfOptom @amy_paine @imagineidnews @MaxAppealUK #22q

[Greg Ngo @GregNgoHP]

@JamesMDewar @cardiffuni @wellcometrust Thanks James! Nice to hear from you! Hope to see you at meetings soon.

[Greg Ngo @GregNgoHP]

I am setting up my lab at @cardiffuni, funded by a @wellcometrust CDA fellowship, to investigate R-loops and genome stability in the pathogenesis of neurodevelopmental disorders. I am looking for two postdocs with a passion for genome stability research to join my lab. Please RT!

[Grant Stewart @GS_Lab_Bham]

Proud to be part of this great study by the Niedzwiedz lab studying the role of actin and actin nucleating factors in regulating DNA replication.