🥳🎆 Kicking of 2026 with our work showing intra-tumoral bacteria 🦠 affect outcomes of Radiotherapy + anti-PD-L1 now out in @NatureCancer with sister paper by @nataliesilvermd! Even when trials "fail" – we can learn from them! https://t.co/0iE2v2sOKZ. -- w/ @GeneCollector, @imrtlee, @TylerAlban1, @DrHaddadRobert, the Pfizer team and more! (1/N)
Pandore study of neoadjuvant pembrolizumab in MIBC reported in @CD_AACR :TFH and IgG directed against urothelium invasive Escherichia coli dictated clinical responses to pembrolizumab. A @GustaveRoussy study with the @GETUG_Unicancer and Zitvogel's lab https://t.co/6EjbY4ea8B
We applied mutational signature based-models to identify patients with functional POLE/D1 mutations. Up to 75% of these patients benefited from immunotherapy in our cohort. The mutation processes shape the biochemical landscape of neoantigens. Check out more @NatureGenet 👇👇👇
What a special gift on (Happy) July 4th! Very happy to share our recent publication @NatureCellBio. Many many thanks to @DanweiHuangfu, all my co-workers #Huangfulab, my collaborators, my training grant @MSK_CSCB. Can't make it without all of you! https://t.co/EKyKM2oB3b
One of my goals in my old position at @MSKPathology was to increase the value we get from NGS results. Our new paper shows one way to do just that - using unmapped reads to discover viruses present in the tissue! 🧵
https://t.co/7G8NrxBOhk
Great work resolving the 3D structure of AvrSr50! Seems to be a novel fold amongst fungal effectors and Alphafold doesn't get the topology quite right yet. AvrSr50 can escape recognition by Sr50 even by a substitution in a single surface exposed residue. https://t.co/u5QCJHA8Qs
I completed Machine Learning with Python! It is a very interesting course with daily life datasets to practice ML skills.
https://t.co/TGC1D84nE7 #Coursera
Check out this #ScienceReview on research that shows how bacteria, viruses & fungi of the microbiome are pervasive among human cancers, are key actors in cancer immunotherapy, & are potentially engineerable to treat metastases: https://t.co/eUyDMj0a52
RESEARCH STUDY: Fungi in the gut may affect how #tumors respond after #RadiationTherapy by disrupting the immune system's response to the cancer. https://t.co/igxmlJfcCe #CancerResearch
MSK stands in solidarity with the Asian, Asian-American, and Pacific Islander (AAPI) community and our colleagues to strongly denounce the recent rise of anti-Asian hate crimes in New York City and across the country. #StopAsianHate https://t.co/2R6MXMiya5