Scacheri Lab

Epigenetics and human disease research lab at Case Western Reserve University School of Medicine -- Department of Genetics & Genome Sciences

[Whitehead Institute @WhiteheadInst]

Genome wide association studies have been used to identify genes that may be linked to opioid use disorder, but need hundreds of thousands of samples.

@MeWantData & collaborators have developed a way to identify these genes, using a small # of samples: https://t.co/EpidCNdIAV

[Corradin Lab @CorradinLab]

Epigenetic convergence in opioid overdose. Great to see this multi-team collaboration in print! Such a great group of people on this project. S. Akbarian, D. Mash, E. Johnson, D. Hancock, @ScacheriLab @Bun_Without_B
https://t.co/1Esq61ykeR

[Scacheri Lab @ScacheriLab]

@TesarLab @AcadofInventors Well deserved. Congrats!

[Scacheri Lab @ScacheriLab]

@YinShenLab @xingjie_ren This is outstanding work! Amazing that an ave of 10 interval genes live between an enhancer and its target gene. How often do functional enhancers/promoters for a given MMR gene lie within the same TAD?

[Jake Scott @CancerConnector]

TWEETORIAL on our new #radonc paper in @TheLancetOncol -- joint work from @CCLRI @MoffittNews @CWRUSOM 1/n

Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD): a cohort-based pooled analysis

https://t.co/3crLxn8VEP

@OncoAlert

[Scacheri Lab @ScacheriLab]

Also, big thanks to Richard Sallari and the @axiotlinc team.

[Scacheri Lab @ScacheriLab]

Our studies are expanding from cancer into other major public health crises. Check out our latest on opioid use disorder. Team effort with Akbarian, Johnson, Mash, and @CorradinLab. https://t.co/bCGg8WOENB

[Angela_Ting @Angela_Ting_PhD]

Recruiting talented data scientists and molecular biologists to work on our newly funded project 👇🏼! This is our collective brainchild with ⁦@BullmanLab⁩ & ⁦@CJohnstonLab1⁩.

Please retweet! Interested applicant please email [email protected] https://t.co/aZBeosg8fB

[Scacheri Lab @ScacheriLab]

@jjm5083 @DFBC_PedCare Great news James. Couldn’t be happier for you!

[Scacheri Lab @ScacheriLab]

Fabulous ecDNA study by Henssen and Koche! Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma | Nature Communications https://t.co/ZUw1dOOYD6

[Scacheri Lab @ScacheriLab]

This article is great! https://t.co/hZUbMbT6RA

[Jake Scott @CancerConnector]

Evolutionary therapy is a new subfield in medicine (distinct from #evomed) that seeks to use our understanding of evolution to enable novel #cancer (& pathogen) therapy. Here we present the first link between #evotherapy and quantum physics. A #thread

https://t.co/8w3h3AliNh

[Scacheri Lab @ScacheriLab]

@cd_mcfarland @PetrovADmitri @leonidmirny We’re so happy to have you Chris!

[Jake Scott @CancerConnector]

How does resistance to targeted therapy develop in #lungcancer? Is it pre-existence or a de novo mechanism? @AndriyMarusyk lab @MoffittResearch adds evidence for a truly Darwinian, gradual development from tolerant persisters to full resistance. A THREAD https://t.co/r0hGbydoZu

[Scacheri Lab @ScacheriLab]

Congrats to @CorradinLab!

[Whitehead Institute @WhiteheadInst]

Multiple sclerosis (MS) is considered an autoimmune disease. Researchers in the @CorradinLab led by @annAmbarbeau & the @TesarLab led by Daniel Factor found a role in MS for cells in the central nervous system—a potential new avenue for MS therapies: https://t.co/qVxzuT7jDD

[Scacheri Lab @ScacheriLab]

Big congrats to freshly minted PhD, Andrew Morton. He just successfully defended his thesis online! @morton_andrew #DamnProud

[Scacheri Lab @ScacheriLab]

To stop COVID-19, test everyone, repeatedly - Sten Linnarsson - Medium https://t.co/cuIWjX6FD9

[Justin Lathia, PhD 🧠🕺🏽 @JustinLathia]

Finished off with some historical sites in Jerusalem, including the western wall. Great tour with @caseccc colleagues including @ScacheriLab

[Richard Koche @RichardKoche]

Excellent preview in @Cancer_Cell covering recent work on the role of extrachromosomal circular DNA in cancer, including our study in @NatureGenet with @anton_gh et al. Thank you for the highlight, Chris Ott. https://t.co/KeKkRL35bn