Fujimoto & Tamura show that glucose starvation remodels the yeast nucleus–vacuole junction via Ypf1 and INSIG homologs, Nsg1 and Nsg2, pointing to a role for fatty acid elongation-linked membrane remodeling in the spatial control of ergosterol biosynthesis https://t.co/XcNPqJgakH
Updated preprint! Here, we identify an SREBP-dependent fatty acid sensing metabolic switch in Drosophila, enabling dramatic metabolic rewiring within adipose tissue that boosts carbohydrate metabolism in the absence of fat.
Read more here:
https://t.co/jvV2JtQHrW
1/3 Thrilled to see our paper led by Kirandeep Deol is out! We used CRISPR screens to uncover regulators of the ferroptosis suppressor FSP1. key discovery: vitamin B2 metabolism stabilizes FSP1 via FAD, revealing a new way vitamins regulate ferroptosis.
https://t.co/6WGXNbGRNf
Thrilled to have contributed to this work led by Jesse Garcia Castillo during his PhD at UC Berkeley w/ Michel DuPage. Targeting FSP1 in T cells boosts anti-tumor immunity by relieving Treg suppression, revealing a new immunomodulatory therapeutic axis. https://t.co/JTQe5BXyrB
With so many great reviews on LDs already out, do we need another?
Sarah @cohenlaboratory & I were approached by @NatRevMCB to organize a review on LD heterogeneity and inter-organelle contacts...topics often in reviews, but not a focus. Fun project!
https://t.co/mSeynTW6vo
Thrilled to share our work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
https://t.co/KFFqoBlBzn
DDHD2, tied to hereditary spastic paraplegia, acts as both a triglyceride lipase and transacylase. While #lipiddroplets don't accumulate in neurons, this raises key questions about fatty acid content and LD dynamics in neurons. 👏 Canals & @airola_lab!
https://t.co/HeGCMdOAzL
Read our latest #research "A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients", published with @SpringerNature in @NatureSMB
https://t.co/vvyeTAHQdj
New paper in @ScienceMagazine identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors!
https://t.co/xSmNywS9PW
Excited to share our new study out in @NatureCellBio! Led by postdoc @MikeLangePhD, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
https://t.co/QBM8e07IlC
Excited to share our new preprint led by Kirandeep Deol! Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to #ferroptosis.
https://t.co/AazDvtfBAF
We are proud to be a founding contributor to https://t.co/pzRYWSMmaI, a repository developed by @TheTafesseLab & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: https://t.co/OdFWCOYmtu #lipidtime
If you're tired of AI and stuff...we published CRISPR-based protocols that you can actually use to delete alpha-synuclein (~100% efficiency) or knock it into endogenous locus (~53% eff) in cultured neurons: https://t.co/zRMfcIAd78