Ashwin D'Souza

PhD student in the BioNanao Tools lab, @StefanDiezLab, @tudresden_de

[DiezLab @StefanDiezLab]

Our preprint is out in @NatureComms where we (with Santen Lab @Saar_Uni) show that vesicles transported by dynein and kinesin exhibit bidirectional motility (with reversals, pauses and fast runs) without any regulators. @digsbb @BCUBE_TUDresden @PoLDresden
https://t.co/HBn000NNbX

[rahgrov @rahgrov]

Finally published-here we show opposite polarity motors bound to vesicular cargo are sufficient for directional reversals. Motors engage in a brief tug-of-war which is resolved by stochastic fluctuations in the number of engaged dynein and kinesin motors diffusing on cargo.

[Ashwin D'Souza @ashwin47]

@ZebrafishRock @PaquetLab Fantastic movie! Is this in real-time or sped up?

[Ashwin D'Souza @ashwin47]

@MAG2ART Great movie! What's the time scale?

[Dylan Burnette @MAG2ART]

A Golgi protein in a cell videoed through a microscope. The Golgi is on the left and I over saturated the display so that we can see the dimmer vesicles trafficking around the cell that also contain sialyltransferase (#FancyScienceWord). #CellBiology

[preLights @preLights]

To move or not to move: A novel in vitro assay successfully recreates intracellular bidirectional cargo transport.

📄 https://t.co/bfka60V1U1

@DivyaA_Pathak covers a #preprint from the @StefanDiezLab and Santen lab, led by Ashwin D'Souza (@ashwin47). Includes author comments 👀

[Journal of Cell Biology @JCellBiol]

A cryo-ET survey of #microtubules and intracellular compartments in mammalian axons, from @_Helen_Foster_, @CamillaVenturaS @Carter_Lab: https://t.co/Sun0jqtXEO

From our Cellular Neurobiology 2022: https://t.co/a6QDruCFwb #SfN22

[☀️ Jon Schwarz ☀️ @schwarz]

By me:

By buying Twitter, Elon Musk has created his own hilarious nightmare https://t.co/wJVjWhrZ0j

[Michael is feeling blue @Schlierf_Lab]

Single-molecule studies provide new views on outer membrane protein biogenesis. Which? Take a look at the review by Anna @asvirh, Neha @nehagc18 and Michael in #BioEssays https://t.co/EtLrjTWgpk @BCUBE_TUDresden

[Arnold Mathijssen @AJTM_M]

Delivering particles with Artificial Microtubules (AMTs) https://t.co/tdtVPae7jh

[Spencer Freeman @spencerSK1]

John, Sergio and I are delighted to share a review that was years in the making. Determinants, maintenance, and function of organellar pH. It has something for everyone! https://t.co/Uwi33yZQBI

[Ashwin D'Souza @ashwin47]

@TushnaKapoor Thank you!

[Ashwin D'Souza @ashwin47]

Always delighted to see this movie! So happy to finally share this work

[rahgrov @rahgrov]

@StefanDiezLab @Saar_Uni Long range motility of vesicular cargo propelled by opposite polarity motors, mimicking intercellular transport, reconstituted in a minimal system.

[Ashwin D'Souza @ashwin47]

https://t.co/uOZFK8z8LZ

[DiezLab @StefanDiezLab]

Very excited to share the preprint of our new results in collaboration with Santen lab (@Saar_Uni). We show Dynein and Kinesins can drive bidirectional vesicle transport in vitro with directional reversals, without regulators. https://t.co/ZKxnd81a73

[Ashwin D'Souza @ashwin47]

@sarc_a_khil @LabRadenovic @StefanDiezLab @jjmajahn @rahgrov All the best Akhil!

[Ashwin D'Souza @ashwin47]

@Peilong_Hou @StefanDiezLab Thanks Peilong!

[Gaia Pigino @GaiaPigino]

I am excited beyond words that this is now out: https://t.co/hC5rDy8aRw.
After so many years of hard work, we can finally answer maaany questions about IFT… 🎉
Thanks Sam @stanuel02 Lacey, @_Helen_Foster_, the cryo-EM facility @humantechnopole, and notably also #AlphaFold2! ❤️

[Dylan Burnette @MAG2ART]

A Golgi protein being trafficked throughout a cell videoed through a microscope.
#Science #Biology #CellBiology #Art

[News from Science @NewsfromScience]

Research on the molecules that seem to resolve inflammation, formally known as specialized pro-resolving mediators, has exploded over the last three decades—but some critics argue a large chunk of these studies may be based on flawed science. https://t.co/BCROG0CBCn