YTC

[Dr. Maalouf ‏ @realMaalouf]

There are over 100 mosques in Toronto, but they decided to pray in the middle of a busy street, blocking commuters and essencial services like ambulances and fire trucks. Why?!

[Isaac @isaacrrr7]

🚨🇬🇧 La policía ignoró a los inmigrantes que acosaban a una mujer en su casa y luego la amenazó con arrestarla por "odio racial" si denunciaba los hechos. Ahora, el hombre que lo expuso está esposado.

Una mujer fue acosada en su casa por inmigrantes. Acudió a la policía, pero no hicieron nada.

Cuando dijo que acudiría a la prensa, la amenazaron con arrestarla por "incitar al odio racial".

Un periodista ciudadano @ActivePatriotUK publicó información al respecto y fue arrestado por "comunicación maliciosa".

Lo retuvieron hasta las 11 de la noche, le confiscaron el teléfono y lo pusieron en libertad bajo fianza durante 3 meses con condiciones estrictas que no puede mencionar.

Esta es la realidad del Reino Unido hoy.

[農藝女孩搬家了 @loveagrogirl]

你聽過台北剴剴案，但你知道台中萱萱案嗎 長達80天的虐待裡，其實萱萱曾有五次可以獲得救援的機會：但五次機會，全都錯過。 一個2歲孩子在三個月內被多次報案、被不同人看到傷勢、被通報為脆弱家庭。台中萱萱案讓人不寒而慄的，不只是施暴的殘酷，而是五次伸出的救命繩索，沒有一次被牢牢抓住。

[Dra. María Natalia Gandur Quiroga @nataliagandur]

#ASCO26 GU Oncology Recap 🚨
🔬 Top GU signals from Days 1–2
Important data across kidney, bladder, and prostate cancer — not all practice-changing, but several clearly practice-informing.
Here are 6 GU signals I’m watching closely:
@OncoAlert
@ASCO
🟧 1. #RADICAL #RCC bone metastases
Presented by @DrRanaMcKay
With GU colleagues/authors: @JoshLangMD @MattGalsky @TiansterZhang @DrChoueiri

Adding radium-223 to cabozantinib in RCC with bone metastases did not improve skeletal event–free survival.
The trial crossed its futility boundary and was stopped early.
Key message:
Bone metastases remain a major unmet need in RCC, but this biologically attractive strategy did not translate into clinical benefit.
Negative trials matter when they close doors clearly.

🟦 2. #SAKK 06/19 #MIBC bladder preservation
Presented by Richard Cathomas
With GU collaborators including @UrsulaVogl

A bladder-preserving strategy using intravesical rBCG + systemic chemo-immunotherapy showed a very promising pathologic response signal.

Reported central pCR was ~65%, with pathologic response ~80%.
Key message:
Bladder preservation is moving beyond classic trimodality therapy.

But we still need careful validation, long-term local control, cystectomy-free survival, and patient selection tools.

🟩 3. #RAD-IO #Durvalumab + chemoradiotherapy in MIBC
Presented by Nicholas D. James
Durvalumab with 5-FU/mitomycin C chemoradiotherapy appeared feasible.
Important delivery signal:
• full RT delivery was maintained
• chemotherapy delivery was largely preserved
• 12-month DFS was encouraging, around 80%

Key message:
Adding IO to bladder-directed CRT is promising, but follow-up is short and randomized data are still needed before changing routine bladder-preservation algorithms.

🟨 4. #RAMPART |Adjuvant RCC
Presented by James Larkin
With key RCC colleagues including @DrChoueiri @tompowles1

Durvalumab + tremelimumab improved DFS vs active monitoring after resection of RCC, with the clearest signal in higher-risk disease.
Higher-risk subgroup:

• 3-year DFS: 76% with durva+trem
• 66% with durva alone
• 61% with active monitoring

Key message:
Adjuvant RCC is becoming more nuanced.
The signal is important, but OS is pending, toxicity matters, and patient selection remains central.
This should not become a “treat everyone” message.

🟥 5. #TALAPRO-3 HRR-altered mCSPC
Presented by @neerajaiims

Talazoparib + enzalutamide significantly improved investigator-assessed rPFS vs placebo + enzalutamide in HRR-altered metastatic castration-sensitive prostate cancer.

Key result:
• HR 0.48
• median rPFS not reached vs 45.8 months
• benefit seen in BRCA and non-BRCA HRR subgroups
But toxicity matters:

Anemia was the major safety signal.
Key message:
Early molecular testing is becoming treatment-shaping in prostate cancer.

But PARP + ARPI intensification should remain biologically selected and toxicity-aware.

🟪 6. #ARACOG / AFT-47 Cognition and ARPI choice
Presented by @AliciaMorgans
Darolutamide vs enzalutamide was studied with cognitive endpoints using CANTAB testing.
Key clinical signal:

• darolutamide-treated patients showed patterns consistent with preserved learning effect/stable cognition
• enzalutamide-treated patients had more stable-to-decreased cognitive scores
• crossover was striking: 30 from enzalutamide to darolutamide vs 0 in the reverse direction

Key message:
ARPI choice is not only about tumor control.

For many patients, cognition, falls, neurologic toxicity, function, and quality of life are part of the treatment decision.
💬 My take from GU Days 1–2
The common theme is not simply “more treatment.”

It is better decision-making:
✓ who needs intensification?
✓ who can avoid unnecessary toxicity?
✓ which biomarkers are actionable?
✓ how do we preserve bladder, cognition, function, and quality of life?
✓ how do we interpret promising early signals without overextending them?

The future of GU oncology is increasingly:

risk-adapted, biomarker-informed, patient-centered, and toxicity-aware.

#ASCO26 #GUOnc #KidneyCancer #BladderCancer #ProstateCancer #RCC #MIBC #mCSPC #PrecisionOncology #Immunotherapy #PARPInhibitors #PatientCenteredCare
@DrChoueiri 🇺🇸 @hoperugo 🇺🇸 @matteolambe 🇮🇹 @TiansterZhang 🇺🇸 @CathyEngMD 🇺🇸 @stolaney1 🇺🇸 @montypal 🇺🇸 @tompowles1 🇬🇧 @brian_rini 🇺🇸 @cdanicas 🇪🇸 @NiuSanford 🇺🇸 @amerseburger 🇩🇪 @GlopesMd 🇺🇸 @Icro_Meattini 🇮🇹 @PGrivasMDPhD 🇺🇸 @DrYukselUrun 🇹🇷 @nataliagandur 🇦🇷 @ElisaAgostinett 🇧🇪 @HHorinouchi 🇯🇵 @realbowtiedoc 🇺🇸 @to_be_elizabeth 🇮🇹 @UOzkerim 🇹🇷 @p_ciracimd 🇮🇹 @DrVilmaPBarcia 🇪🇸 @DraMartinezLago 🇪🇸 @DrMirallas 🇺🇸 @GaiaGriguolo 🇮🇹 @MarioBalsaMD 🇪🇸 @scocmem 🇬🇧 @AmandaNizamMD 🇺🇸 @weoncologists 🇺🇸

[Rashid K. Sayyid @RKSayyid]

Formula-01: Ph 2 trial of disitamab vedotin (RC48) + BCG in HER2-high HR-NMIBC (HER2 IHC 2+/3+)
n=78
Baseline features:
🔹T1 disease: 73%
🔹Multifocal tumors: 67%
🔹Tumor size >3 cm: 55%
🔹Concomitant CIS: 12%

Efficacy (median f/u 15 mos):
🔹6-mo DFS: 97.4%
🔹1-yr DFS: 92.2%
🔹Only 6 recurrences/progressions
🔹No deaths

Safety:
🔹Grade 3-4 TRAEs: 12.8%

📌RC48 + BCG demonstrated promising activity in a biomarker-defined population known to be at high risk for BCG failure

@urotoday
#ASCO26

[Nick Sortor @nicksortor]

🚨 JUST IN: President Trump announces Medicare patients will begin receiving weight loss drugs like Ozempic for $50 PER MONTH starting July 1

It's currently $1,300!

That's a HELL of a reduction.

[YTC @cghr4]

@UroDocAsh @tompowles1 @MaxKates @LauraBukavinaMD @SWilliams_MD @shilpaonc Reduced dose still elicit immune respons. Same as Pembro, Nivo & all ICI.

[Vivid.🇮🇱 @VividProwess]

🚨BREAKING: The IDF has found A 25-meter-deep underground Hezbollah command center inside a clothing store in Lebanon.

Massive amount of weapons were found.

Share this. The mainstream media won’t.

[Eyal Yakoby @EYakoby]

BREAKING: The Islamic Republic is preparing to hang eight women.

Not a word from the international community or so-called human rights organizations.

[Nick shirley @nickshirleyy]

🚨 Exposing California's corrupt "Stop Nick Shirley Act", instead of going after the fraudsters California is now going after the people exposing the fraud.

This bill AB 2624 will:
- Criminalize journalists with misdemeanors, $10,000 fines, imprisonment, and content takedown
- Let immigrant based NGOs' funding be confidential
- Take away freedom of the press from journalists
- Protect any "immigration support services" information from being public (healthcare, legal services, etc)

This bill was created by the Attorney General's WIFE Mia Bonta to stop fraud from being exposed. Please like and share this video everywhere! By trying to silence and intimidate journalists, they are trying to hide the truth from you. EXPOSE ALL THE FRAUD.

[Don Keith @RealDonKeith]

🚨Steve Hilton drops a bombshell on Fox News:

California Dems stole a staggering $434 BILLION from taxpayers in just 5 years — bigger than every other state combined.

Young Nick Shirley is crushing their slush funds left and right.

[Eric Daugherty @EricLDaugh]

🚨 HOLY CRAP! Nick Shirley FOLLOWED the California Speaker of the House and a Senator for pushing the Stop Nick Shirley Act, which CRIMINALIZES anti-fraud journalism

They were stumbling, panicked, REFUSING to acknowledge that levying up to $50K fines for journalism is TYRANNY

SHIRLEY: "Speaker Rivas...AB 2624? Is there a conflict of interest with Mia Bonta, and her husband being the ATTORNEY GENERAL?"

RIVAS: "I don't know." *Runs into car* 🤯

SHIRLEY: "These people won't even answer the questions."

[Helen 🇺🇸👉PASS THE SAVE ACT @helen_maga99]

🚨史蒂夫·希尔顿在福克斯新闻上爆出一个重磅消息：

加州民主党人在短短5年内从纳税人那里窃取了惊人的4340亿美元——这比所有其他州加起来的总额还要多。

你敢想像吗？他们居然要制定法律治罪揭露者——尼克.雪利

[花岗岩³ @Granite77777]

🚨 哇！尼克·雪莉（Nick Shirley）当面直球质问加州众议院议长，针对“停止尼克·雪莉法案”（Stop Nick Shirley Act）！

结果，她当然转身就跑了！

@nickshirleyy：“这些人连问题都不敢回答！”

腐败真是疯了。

[CNToWest @CNToWest]

英国罗瑟勒姆的穆斯林市长，她说英国只有实行伊斯兰教法才能再次伟大，要求驱逐所有非穆斯林！包括英国🇬🇧公民

[墓碑科技 @mubeitech]

川普政府在洛杉矶一口气端掉了近 500 家临终关怀机构。
断了这么多人的财路，结果却非常奇葩。
没有一家机构跳出来要求恢复资金。
连国会都没人打一个电话来抱怨。

为什么？
卫生部长 RFK Jr. 把账本抖了出来。
因为这 500 家机构绝大多数连实体都没有，地址全是瞎编的。
他们根本不照顾病人，专门找活人套现。

套路极其简单粗暴。
骗子跑到贫困社区，直接给人塞一台平板电视，外加 600 美元现金。
条件只有一个，交出身份信息，挂名登记进临终关怀名单。
名单一造好，账单就送到了卫生部。

每登记一个人头，政府就要向这些空壳机构支付 6000 美元。
花 600 块的本钱，套 6000 块的公款。
十倍的暴利，吸的全是医疗系统的血。

现在，这台榨钞机被彻底砸烂了。

[YiFeng Su @sam51824016070]

还记得香港反送中的那些影片吗？

当时，大量抗争者被押上火车送往中国。 整列列车密封，车窗用黑布遮挡，传出女生的惨叫声——

他们到底被送去了哪里？ 遭遇了什么？
没人知道... ...

台湾人啊，真的要清醒,
一旦中共全面入侵，这可能就是台湾的未来!

[Eyal Yakoby @EYakoby]

How is this not racist?

[Dra. María Natalia Gandur Quiroga @nataliagandur]

💫🌟#UTUC: same disease… different guidelines?
@EUplatinum @OncoAlert
A thought-provoking editorial in European Urology highlights key divergences between AUA and EAU recommendations in upper tract urothelial carcinoma.
🔹 1. A rare disease, fragmented evidence
UTUC has long been managed by extrapolation from bladder cancer
👉 But biology and clinical behavior are clearly distinct

🔹 2. Where guidelines diverge
• 🔍 Diagnosis & staging → variability in imaging and nodal assessment
• 💊 Perioperative strategy → timing of chemotherapy (neoadjuvant vs adjuvant)
• 🧬 Systemic therapy integration → evolving role of IO and adjuvant approaches
👉 Reflects not only evidence gaps… but regional practice patterns

🔹 3. The real issue: evidence vs reality
• Limited prospective trials
• High rates of clinical vs pathological discordance
• Persistent uncertainty in risk stratification
💡 My take:

This is not just about guideline differences.
It’s about the challenge of practicing precision oncology in rare tumors with limited data.
👉 We don’t need more guidelines
👉 We need better, UTUC-specific evidence
@ecancer @MedicalwatchHQ @urotoday @UrologyTimes
🔗 https://t.co/oC9h4FqXLP

#UTUC #UrothelialCancer #GUOnc #PrecisionOncology #OncoTwitter

[World Affairs @World_Affairs11]

BREAKING:

🇸🇦 Saudi Arabia fully restores East-West oil pipeline, bypassing the Strait of Hormuz and pumping 7,000,000 barrels per day.

Saudi Arabia says it needs no more strait of Hormuz.