chatrin

Postdoc @IvanAhelLab @Dunn_School. Enamored by #PTMs,and the world of #ubiquitin and #ADP-ribosylation

[chatrin @chatrin_ch]

The first paper from my PhD is out @ScienceAdvances! It's a tale of two #PTMs brought together by Deltex E3. Deltex surprisingly binds #NAD and modifies #ubiquitin tail with #ADPribose. This inactivates Ub, but is readily reversed by deubiquitinases. (1/3) https://t.co/NsnYOgAjS1

[Yifat Merbl lab @YMerbl]

Congratulations to the Poster Award winners #EMBOubiquitin24: Jason Collins from ⁦@werner_achim⁩ Kai Gallant from ⁦@MalteGersch⁩ and Chatrin Chatrin from ⁦@IvanAhelLab⁩
Well done! 👏💫🏆 ⁦@YKulathu⁩ ⁦@polosimona1⁩ ⁦@LabJoazeiro⁩

[Mark A. Nakasone @Mark_A_Nakasone]

It has been an honour to host @UniofOxford's @chatrin_ch on her Scotland 🏴󠁧󠁢󠁳󠁣󠁴󠁿 tour's 1st stop in Dundee. We had many activities and reunited @CRUK_SI alumni @IPuoti and Helge. Very exciting work on #ubiquitin ADP-ribose from her PhD & postdoc work. Nice late night walk on the sea cliffs with @KevinHaubrich1

[Mark A. Nakasone @Mark_A_Nakasone]

We uncovered how UBE2K extends K48-linked #ubiquitin in @nchembio with our @CRUK_BI team (@gazsib), @UoGBioPhys (@maxgabro), and @BrianOSmith1967 using integrated structural biology 🧲#NMR & 💎 #Xray: https://t.co/P1cdG1igs1 #openaccess

[chatrin @chatrin_ch]

@AnhHLe2702 @mayor_lab @BristolBiochem Congratulations, Anh!!

[chatrin @chatrin_ch]

@vBarthet @IPuoti @ChelseaGerada1 Congratulations, Valentin!!

[chatrin @chatrin_ch]

@mediocre_jake @ScienceAdvances It's not too late to start now 😉

[chatrin @chatrin_ch]

The first paper from my PhD is out @ScienceAdvances! It's a tale of two #PTMs brought together by Deltex E3. Deltex surprisingly binds #NAD and modifies #ubiquitin tail with #ADPribose. This inactivates Ub, but is readily reversed by deubiquitinases. (1/3) https://t.co/NsnYOgAjS1

[chatrin @chatrin_ch]

@vwang93 I enjoyed reading your take on the books. Might try to read Kuhn 🤓

[chatrin @chatrin_ch]

@AnhHLe2702 Congratulations! 🎊🎉

[chatrin @chatrin_ch]

No 🚰🚿

[Scottish Water @scottish_water]

We have located a burst water pipe on Bearsden Road which is impacting customer supplies in the #G3, #G11, #G12, #G13, #G14 and #G15 area of west Glasgow. Our teams are on-site to shut out the burst and begin to restore water supplies. https://t.co/fv747EE0b6

[CRUK Scotland Inst @CRUK_SI]

1/13 COVID-19 had a significant impact on our research activity but our researchers adapted brilliantly and work @CRUK_BI continued to thrive. This #WorldCancerDay #WCD2021 , we're highlighting just some of the successes from the past year:

[chatrin @chatrin_ch]

Creative approach to switch CAR T cells on/off! Achieved through CRBN-degron interaction induced by lenalidomide. Cool system.

[Science Magazine @ScienceMagazine]

Researchers have created new variants of anticancer CAR T cells that can be quickly switched on and off with a clinically approved drug, allowing precise control over the cells’ activities. Read more in @ScienceTM: ($) https://t.co/Qzv3R3kPqY

[chatrin @chatrin_ch]

@AnhHLe2702 I see facial features 😯

[bioRxiv Cell Biology @biorxiv_cellbio]

Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states https://t.co/l1izf2yYIT #biorxiv_cellbio

[chatrin @chatrin_ch]

😮
‘The game has changed.’ AI triumphs at solving protein structures https://t.co/3o4TpakdX7

[chatrin @chatrin_ch]

@MSuskiewicz @maxgabro @Mark_A_Nakasone @ferojahmed @gazsib @DSumpton @BrianOSmith1967 @CRUK_BI @UofGMVLS Thank you! It took us by surprise as well 🙂

[chatrin @chatrin_ch]

@jnpruneda We're excited about this too! Thanks for sharing :)

[chatrin @chatrin_ch]

Thanks to @maxgabro @Mark_A_Nakasone @ferojahmed @gazsib @DSumpton @BrianOSmith1967, twitterless Lori and Danny for their contributions. I am also grateful to @CRUK_BI for sponsoring and hosting my PhD, it's a great place to do science. @UofGMVLS (3/3)

[chatrin @chatrin_ch]

#PTMs are like codes that are branded onto a target protein. The codes are read by dedicated "readers", which can change a protein's cellular fate. Ub itself is a protein, so it can be modified by other small PTMs - and we have a brand new code! (2/3)