Top Tweets for #Protac
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Protein degradation will be one of the most important
investment themes of the next decade.
The Roche-Nurix deal this week
put a $2.3B number on the platform.
That is just the beginning.
Follow @BioAlphaa for weekly coverage.
NFA. DYOR. #Biotech #PROTAC
🔬 新着リリース｜1,000種類以上の新規研究用分子を公開
本リリースでは、#腫瘍学 #神経科学 #免疫・炎症 #代謝疾患などの主要分野を強化し、創薬研究および基礎研究の幅広いニーズに対応します。
主な研究分野：
✔ #PROTAC による標的タンパク質分解
✔ RNA編集制御（#ADAR1）
✔ 神経炎症・自然免疫（TREM2、NLRP3）
✔ 炎症シグナル経路（PDE4B、IL-36R、LPAR1）
✔ 骨代謝制御（RANKL）
多くの化合物は、経口バイオアベイラビリティ、血液脳関門（#BBB）透過性、高い選択性、良好な薬物動態プロファイルなどの優れた特性を有し、標的検証、作用機序解析、初期創薬研究を強力にサポートします。
🔬 高品質なバイオアクティブ分子で、画期的な研究を支援します https://t.co/YH9RdGZbXM
#創薬研究 #神経炎症 #低分子化合物 #研究ツール #免疫学 #腫瘍学 #代謝研究 #ライフサイエンス #バイオテクノロジー
米国初のPROTAC承認。塩野義のコロナ予防薬「Xocova」やビーワンのBCL2阻害剤など、2026年5月にFDAが承認した新薬群。PROTACという新しい創薬モダリティの本格的な市場参入が始まる。 https://t.co/xvW3cRWptF #PROTAC #新薬承認 #FDA @Answers_News
🔥Hot Off the Press | Nb-PROTAC Enables Broad-Spectrum Anti-Influenza Breakthrough
#InfluenzaA viruses continue to pose a major global health challenge due to rapid mutation and frequent drug resistance. A new study introduces a nanobody-based #PROTAC (Nb-PROTAC) strategy that shifts antiviral therapy from functional inhibition to targeted viral protein degradation.
🚀By fusing NP-specific nanobodies with the VHL E3 ligase component, the system directly drives degradation of the highly conserved influenza nucleoprotein (NP), offering a novel antiviral modality.
✔️ Pan-subtype NP degradation across all 16 influenza A subtypes (H1–H16)
✔️ Strong inhibition of H1N1, H3N2, H5N1, H7N9, and H9N2 replication
✔️ In vivo AAV-LungM3 delivery achieved 90% (H1N1) and 80% (H5N1) survival in lethal models
✔️ Mechanistically involves the autophagy–lysosome pathway, with OPTN participation
Nb-PROTAC represents a modular and programmable antiviral platform with strong potential for broad-spectrum and next-generation infectious disease control.
MedChemExpress provides #Puromycin, #LY294002, and #MG132 to support this study, along with 5,000+ PROTAC-related reagents and one-stop services covering design, synthesis, optimization, and evaluation, empowering and accelerating your scientific research.
#NbPROTAC #TargetedProteinDegradation #AntiviralResearch #Influenza #DrugDiscovery #Biotechnology #Virology #ScienceNews #Biomedicine
A major milestone for #ProteinDegraders: the FDA approved Pfizer & Arvinas’ oral #PROTAC therapy vepdegestrant a month ahead of the expected date. We’re excited by this progress & continue to support development with high quality #biospecimens & services: https://t.co/0OxoEfbjRE
💊#FDA Approval Update | #Vepdegestrant (#Veppanu) approved for advanced/metastatic breast cancer
🔸A first-in-class #PROTAC that goes beyond inhibition, driving degradation of its target protein.
🚀A validation of an entirely new therapeutic modality.
🌟MedChemExpress offers vepdegestrant for research use only: https://t.co/aMjCngnPku
#BreastCancer #Biotech #Pharma #MedicinalChemistry #FDAApproval
💊#FDA Approval Update | #Vepdegestrant (#Veppanu) approved for advanced/metastatic breast cancer
🔸A first-in-class #PROTAC that goes beyond inhibition, driving degradation of its target protein.
🚀A validation of an entirely new therapeutic modality.
🌟MedChemExpress offers vepdegestrant for research use only: https://t.co/ORZIGTHLxF
#BreastCancer #Biotech #Pharma #MedicinalChemistry #FDAApproval
First ever #PROTAC @FDAOncology approval based on @Yale @YaleCancer dr Craig Crews lab discoveries for ER+ve metastatic breast cancer (Dr Crews work also led to approval of carfilzomib for #MMsm approval in 2012) https://t.co/RZHQhJzxCu
I am very happy to share our very first article on the #PROTAC discovery just out in @rsc_medchem !
https://t.co/FzEoDRxef1
#UkraineStands #terroruzziMustDie #ProteinDegradation
@EnamineLtd @KyivUniversity
The Dawn of Targeted Protein Degradation (TPD) in Oncology!
On May 1, 2026, the #FDA approved Vepdegestrant, the first-in-class PROTAC drug, for ESR1-mutated ER+/HER2- metastatic breast cancer.
#BreastCancer #Oncology #PROTAC #PrecisionMedicine #FDAApproval
$ARVN FDA approval
https://t.co/o22KYPe5v3
It‘s time to remove the question mark!
A huge congrats to @CraigMCrews, Ray Deshaies and the scientists @ArvinasInc.
1st FDA approval for a #PROTAC on May 1st 2026. A day to remember. Extra drinks at the Proxidrugs GRC in a few weeks!
The first #PROTAC protein degrader therapy is now approved by the U.S. FDA. Developed with @Pfizer, this heterobifunctional protein degrader is approved to treat adults with ER+/HER2-, ESR1-mutated advanced or metastatic #breastcancer, as detected by an FDA-authorized test, with disease progression following at least one line of endocrine therapy.
Read more: https://t.co/n6uE5XaQds
#proteindegradation
Happy to share that our paper “SE(3)-PROTACs: Geometric Deep Learning for PROTAC Degradation Prediction” has been accepted for publication in the Q1 journal Briefings in Bioinformatics.
#AI #DrugDiscovery #PROTAC #Bioinformatics #BioPharma
Ponzo et al (2026) Proximity Binding Assay for #PROTAC Ternary Complex Analysis. ACS Sens #TPD #biophys #DrugDesign #MedChem #cheminformatics #OpenAccess
https://t.co/amtitmYRpX
Our preprint on "Pro-GAT: Reconnecting Fragmented PROTACs Using a Graph Attention Transformer" is now available on bioRxiv.
Check it out: https://t.co/RUXxmbYae0
#AI #DrugDiscovery #PROTAC #ComputationalBiology #ProGAT #Pharma #Drugparadigm
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