#RIBOSIDE - Twitter Hashtag

almost 2 years ago

Effect of #nicotinamide #riboside (#NR) on airway inflammation in #COPD: a randomized, placebo-controlled trial @NatureAging Major Outcomes After 6 weeks of NR supplementation, the estimated treatment difference in sputum IL-8 levels in COPD patients was -52.6%. This effect persisted during follow-up at 12 weeks post-treatment (-63.7%). However, due to the small sample size and wide confidence intervals, these findings should be interpreted with caution. Secondary Outcomes: 1. Whole Blood NAD+ Levels: NR supplementation increased whole blood NAD+ levels by 71.1 µM in COPD patients and by 49.4 µM in lung-healthy controls. At the 12-week follow-up after treatment cessation, NAD+ levels had completely returned to baseline. 2. Plasma IL-6 Levels: COPD patients had higher levels of the SASP cytokine IL-6 in plasma compared to lung-healthy controls, but no effect of NR treatment was detected. Other Findings: 1. Epigenetic Age of Peripheral Blood Mononuclear Cells (PBMCs): A general trend of reduced epigenetic age was observed in COPD patients following NR treatment. 2. RNA Sequencing of Nasal Epithelial Cells: NR supplementation led to the upregulation of gene sets associated with genome integrity maintenance in both COPD patients and lung-healthy controls. Notably, NR supplementation downregulated gene sets related to immunity and antigen processing in both groups. 3. Senescence Predictions in Sputum: While nuclear morphology-based senescence levels were unaffected after 6 weeks of NR supplementation, a reduced IR-like senescence pattern, predictive of cellular aging, was observed in the NR group compared to placebo at 12 weeks post-supplementation.

Titus12629950's tweet photo. Effect of #nicotinamide #riboside (#NR) on airway inflammation in #COPD: a randomized, placebo-controlled trial
@NatureAging

Major Outcomes
After 6 weeks of NR supplementation, the estimated treatment difference in sputum IL-8 levels in COPD patients was -52.6%. This effect persisted during follow-up at 12 weeks post-treatment (-63.7%). However, due to the small sample size and wide confidence intervals, these findings should be interpreted with caution.

Secondary Outcomes:
1. Whole Blood NAD+ Levels:
NR supplementation increased whole blood NAD+ levels by 71.1 µM in COPD patients and by 49.4 µM in lung-healthy controls. At the 12-week follow-up after treatment cessation, NAD+ levels had completely returned to baseline.
2. Plasma IL-6 Levels:
COPD patients had higher levels of the SASP cytokine IL-6 in plasma compared to lung-healthy controls, but no effect of NR treatment was detected.

Other Findings:
1. Epigenetic Age of Peripheral Blood Mononuclear Cells (PBMCs):
A general trend of reduced epigenetic age was observed in COPD patients following NR treatment.

2. RNA Sequencing of Nasal Epithelial Cells:
NR supplementation led to the upregulation of gene sets associated with genome integrity maintenance in both COPD patients and lung-healthy controls. Notably, NR supplementation downregulated gene sets related to immunity and antigen processing in both groups.

3. Senescence Predictions in Sputum:
While nuclear morphology-based senescence levels were unaffected after 6 weeks of NR supplementation, a reduced IR-like senescence pattern, predictive of cellular aging, was observed in the NR group compared to placebo at 12 weeks post-supplementation.

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J P Fanton

@HealthyFellow

over 2 years ago

#Nicotinamide #riboside for peripheral artery disease: Randomized clinical trial ⁦@_atanas_⁩ ⁦@_INPST⁩ ⁦@ScienceCommuni2⁩ ⁦@DHPSP⁩ ⁦@HeidiHmoretti⁩ ⁦@BowTiedVitamins⁩ ⁦@agingdoc1⁩ ⁦⁦@ChrisMasterjohn @AzCIM https://t.co/dOBdaa8C0y

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J P Fanton

@HealthyFellow

almost 4 years ago

Just posted! @ChrisMasterjohn unpacks the topic of the moment: Does #Nicotinamide #Riboside Fuel #Cancer Growth? https://t.co/Fk9t4qqEup Attn: @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @veritas2200 @Grimhood @agingdoc1 @chydorina @LifeExtension @TheAgingField @davidasinclair

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Peptide Sciences @PeptideScience

over 5 years ago

NAD+ in Aging: Role of #Nicotinamide #Riboside and Nicotinamide #Mononucleotide “Aging can cause #NAD+ levels to drop. This causes metabolic & #mitochondrial dysfunction, as well as problems & conditions associated with #aging like elevated #DNA damage…” https://t.co/3Rxf5DkBMU

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Longevity Technology @LongevityTech

about 6 years ago

NAD-boosting may stabilise #telomeres to slow #aging A recent study shows that #nicotinamide #riboside helps alleviate #telomere dysfunction in human cells. #longevity #NAD #senescence @NIH @ChromaDex https://t.co/kpq4s1EmRp

LongevityTech's tweet photo. NAD-boosting may stabilise #telomeres to slow #aging
A recent study shows that #nicotinamide #riboside helps alleviate #telomere dysfunction in human cells.
#longevity #NAD #senescence @NIH @ChromaDex https://t.co/kpq4s1EmRp https://t.co/xH0gpaAojJ

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J P Fanton

@HealthyFellow

over 6 years ago

#Nicotinamide #Riboside - The Current State of #Research and Therapeutic Uses Attn: ⁦@davidasinclair⁩ ⁦@_atanas_⁩ ⁦@_INPST⁩ ⁦@LifeExtensionR⁩ ⁩ ⁦@DrPalmquist⁩ ⁦@deNutrients⁩ ⁦@bengreenfield⁩ https://t.co/rx4zhiYXsZ

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TheHealthyRD

@HeidiHmoretti

about 8 years ago

Is niacin a key to the fountain of youth? Read about niacin here: https://t.co/FsrkddsoYc #niacin #nicotinamide #riboside #aging #antiaging #DNA #energy #youth

HeidiHmoretti's tweet photo. Is niacin a key to the fountain of youth? Read about niacin here: https://t.co/FsrkddsoYc #niacin #nicotinamide #riboside #aging #antiaging #DNA #energy #youth https://t.co/37e6hKh4qB

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Glocentrica.com @Glo1inducer

over 8 years ago

#Nicotinamide #riboside was without effect in #obese men (Amer Clin Nutrit , https://t.co/qLY3KuuT3y ). Don’f despair! #Resveratrol #hesperetin in combination reversed insulin resistance in 8 weeks treatment. See report in #Diabetes 2016; 65, 2282-2294. https://t.co/FUfjRtI4QX

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Disabled World (DW) Disability News Service

@DisabledWorld

over 8 years ago

Study indicates when people consume a natural #dietary #supplement called #nicotinomide #riboside daily, it mimics #caloric restriction kick-starting the same key #chemical pathways responsible for its #healthbenefits --> https://t.co/1Pvp6dVz0R

DisabledWorld's tweet photo. Study indicates when people consume a natural #dietary #supplement called #nicotinomide #riboside daily, it mimics #caloric restriction kick-starting the same key #chemical pathways responsible for its #healthbenefits --> https://t.co/1Pvp6dVz0R https://t.co/BM9Is6FXQF

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αℓι'ѕ ωєℓℓ 🍖🏋️‍♂️😴

@Ali_s_Well

almost 9 years ago

مكملات تحسين صحة الخلية: #PQQ #Nicitinamide #Riboside #Resverstrol على اليمين المجموعة اللي استخدمتها السنة الماضية. على اليسار اللي بدأت استخدمهم اليوم. أكبر تغيير ان #الرزفيراترول الجديد سائل بدل كبسولات (اقتراح من شخص عزيز).