qicy

3D genome architecture and single cell multimodal and spatial sequencing

[Diego A. Díaz-García @diegoadiazg]

🚨 Cancer dormancy and metastasis.

Dormant disseminated cancer cells can evade immune surveillance and reactivate years later, driving metastatic relapse.
Understanding dormancy biology may enable biomarkers and therapies that prevent recurrence before metastases develop.

📖 @NatureRevCancer
DOI 👉🏻 https://t.co/qkjbkhfZsc

#CánCare #oncology #metastasis #cancerdormancy

[antisense. @razoralign]

GatorPrism: Prototype-Conditioned Routing across Coalition Graph Experts for Spatial Multi-Omics Integration https://t.co/y7AROkQ5iX

[Gut Journal @Gut_BMJ]

How liver cells regulate inflammatory injury remains an area of intense investigation.

Chen et al. present "A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis" via

https://t.co/Dn4Pzs72hX

This elegant mechanistic study identifies A20 as a key regulator of ferroptosis through modification of KEAP1, limiting liver injury in autoimmune hepatitis. The findings complement this issue's accompanying commentary and highlight ferroptosis as an increasingly important therapeutic target in immune-mediated liver disease.

#AutoimmuneHepatitis

[Lukas Valihrach @LukasValihrach]

Spatialproteomics: an interoperable toolbox for analyzing highly multiplexed fluorescence image data
https://t.co/M3OoMH0Zig

[Aging Science News @AgingBiology]

Spike-in-normalised single-cell RNA-seq reveals cell-type-specific transcriptional repression during ageing
https://t.co/OOhhIEg93E

[Ruslan Rust @rust_ruslan]

Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer’s disease @ScienceMagazine

https://t.co/dIGWSvrxcK

[Ming "Tommy" Tang @tangming2005]

A nice python package for creating Publication-Ready Scientific Plots https://t.co/WX2kvXtzxU

if you use R, take a look at https://t.co/HgyiQA7CbA

[Cell @CellCellPress]

In the latest issue! Multimodal imaging of gene expression, morphology, and activity of the same neuron https://t.co/EqKFLocWCA

[Cell @CellCellPress]

In the latest issue! Continuous modeling of primate embryogenesis from totipotency to early organogenesis https://t.co/ax3S33Nxio

[Sushmita Roy @sroyyors.bsky.social,genomic.social @sroyyors]

Some more interesting papers on long-range gene regulation/3D genome organization:
1. Distance important for enhancer-promoter interactions https://t.co/NuTB8URRZc
2. Role of pioneer TFs in 3D genome organization: https://t.co/9T2GjeadnJ

[IdoAmitLab @IdoAmitLab]

Very interesting study by @FGinhoux and co. Demonstrating critical stage specific DAM-T cell interactions during glioma progression
https://t.co/wakmk2CuVe

[Junyue @junyue_cao]

Our paper is officially out in @NatureComms today https://t.co/agenNa0A8k Congrats to @xu_zxu and Aileen from the lab!

[Cell @CellCellPress]

In the latest issue! Deep learning of functional perturbations from condensate morphology https://t.co/OfKhS3RvDo

[Anders Sejr Hansen @Anders_S_Hansen]

We know little about proteins required for long-range compartment 3D interactions, but this @KylePEagen lab preprint shows that NSD3 can make Mb-scale long-range compartment-like interactions:
https://t.co/80KXROkSos

[Katalin Susztak @KSusztak]

👏 📄 awesome paper by Junnan Wu (Susztaklab alumni) -Single cell and high-resolution spatial profiling of podocytopathies reveals core mechanisms of podocyte injury | @ScienceAdvances https://t.co/e7h0tqnurn

[watanabe lab 🔬 @EManiax]

New preprint alert from the Watanabe lab!! Have you wondered what microglia are surveying with their motile processes? Have you wondered what happens to proteolytic organelles that are stuck in axons? Check this out! Microglia are the garbage man! https://t.co/iMvR86HpX7

[Cell @CellCellPress]

In the latest issue! Decoding the spatiotemporal development of human meninges https://t.co/iryALTZxiX

[Katie Galloway @GallowayLabMIT]

Nice work from lab of @BintuLacra !

[Immunity @ImmunityCP]

Online now: Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma https://t.co/GNRWJGezF4

[Cancer Cell @Cancer_Cell]

Online Now: A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression https://t.co/pUBP6q29lK