Rakesh

Scientist | Postdoc @PennMedicine | PhD @iitbombay | Computational Biologist | Website:

[Rakesh @rakez_krish]

Excited to share our latest publication in Molecular Biomedicine! 🎉 We engineered a cyclotide-based antimicrobial peptide with enhanced stability and intracellular activity against MRSA. Proud to contribute the molecular docking & MD simulations. 🧬📄 https://t.co/pMG1bxrc2d

[Rohit Joshi @RohitjoshiB]

Excited to share our latest work in @BiophysJ showing how hypoxia reshapes nuclear mechanics and nuclear envelope architecture, enabling enhanced cell migration and invasion.
https://t.co/UF09eOdDca

@abhijit_MLab

[Ranjith Padinhateeri @ranjithpa]

Happy to share our Current Opinion review on the key challenges in accurately predicting 3D distances between chromatin segments and computing their dynamics. Thanks to Daniel Jost @djost_physbiol & Luca Giorgetti for the invitation to write this review @DuttaShuvadip @BsbeIitb

[Ranjith Padinhateeri @ranjithpa]

How does 3D chromatin organization affect translocations? Our work shows that translocation probability depends not just on local contact probability, but also on global chromatin compaction.
Cool work by Anirudh (then an MTech student @BsbeIitb), with @DuttaShuvadip et al.

[Nature Portfolio @NaturePortfolio]

A paper in @NatureMicrobiol reports that the use of AI to mine proteomes of archaea led to the discovery of archaeasins, antimicrobials that kill drug-resistant bacteria in laboratory and animal models, offering a promising source of future antibiotics. https://t.co/Z1KKEqbD6Y

[bioRxiv Biophysics @biorxiv_biophys]

Predicting statistics of gene translocation events: role of chromatin compaction and double-strand DNA break https://t.co/5vFnzikcy9 #biorxiv_biophys

[César de la Fuente @delafuentelab]

For over a century, the hunt for new antibiotics has focused almost exclusively on bacteria and fungi. Today, that paradigm shifts. By coupling state-of-the-art AI with the vast, largely uncharted diversity of Archaea, we open a new frontier for molecular discovery.

Our APEX model sifted through hundreds of archaeal proteomes in silico, revealing a previously hidden family of antimicrobial peptides we call “archaeasins.” Of the 80 candidates we synthesized, 93% were active against pathogenic microbes in vitro, and one—archaeasin-73—matched the in-vivo efficacy of last-resort drugs such as polymyxin B.

These results show that the marriage of deep learning and evolutionary diversity can surface potent therapeutics at digital speed, expanding the antibiotic toolbox when humanity needs it most. Archaea, once thought biologically esoteric, now stand alongside bacteria and fungi as a rich reservoir of useful molecules.

We are excited to keep discovering antibiotics at digital speed with AI.

Link to the paper @NatureMicrobiol @NaturePortfolio: https://t.co/6BE2mO7GbR

[Shuvadip Dutta @DuttaShuvadip]

Our new work "Liquid–liquid phase separation of lamin drives altered chromatin organization in cardiomyopathic mutations of lamin A" is now out in NAR.

Experiments by @Subhradip1225, Shreyasi & Duhita.
Led by @mithunmittir & Kaushik Sengupta.

🔗https://t.co/Ln3tHVR38i

[Penn Medicine CSO @PennMedCSO]

ft. @megclarks, Walter Mowel, @MFMich1, Leonel Joannas, @Notorious_MHC, Isabel Erickson, Jorge Henao-Mejia (@PennPathLabMed), Lexus Johnson, @andyjminn (@UPenn_I3H), @rakez_krish, @delafuentelab (@PennPsych) & @ksimeono (@PennVet) @ImmunityCP https://t.co/vSZ3dNJBwN

[César de la Fuente @delafuentelab]

(1/5) Venoms are a vast, largely untapped library of bioactive molecules—and our new paper in @NatureComms @NaturePortfolio reveals just how powerful they can be. 🐍⚡️https://t.co/wQIpsu3zhz

[Satya Dev PVS @SatyaDev2064]

@biorxiv_genomic Excited to share our paper on the changes in 3D chromatin architecture across cell cycle stages in the pathogenic basidiomycete yeast, Cryptococcus neoformans. @ranjithpa @KaustuvSanyal @DimpleNotani @DuttaShuvadip @rakeshnetha_v

[HaystackAnalytics @HaystackLab]

🚨 We’re hiring !

📌 Roles: Sequencing Services
– Associate – Business Development, (Freshers)
– Area Sales Manager – (3–4 yrs experience)
📍 Delhi, Mumbai, Bangalore, Hyderabad, Chennai
📩 [email protected]

#Hiring #NGS #BiotechJobs

[HaystackAnalytics @HaystackLab]

🚨 We’re hiring!

📌 Roles:
– Associate – Business Development, Sequencing Services (Freshers)
– Area Sales Manager – Sequencing Services (3–4 yrs experience)
📍 Delhi, Mumbai, Bangalore, Hyderabad, Chennai
📩 [email protected]

#Hiring #NGS #BiotechJobs

[HaystackAnalytics @HaystackLab]

🚨 We are hiring !

📌 Roles: Sequencing Services
– Associate – Business Development (Freshers)
– Area Sales Manager – (3–4 yrs experience)
📍 Delhi, Mumbai, Bangalore, Hyderabad, Chennai
📩 [email protected]

#Hiring #NGS #BiotechJobs

[César de la Fuente @delafuentelab]

(1/3) New in @ImmunityCP @CellPressNews: A single protein inside mitochondria, NDUFA4, keeps some immune cells in tumors “asleep.” Cutting its levels wakes them up, so they start attacking the cancer https://t.co/s76eLekO5m

[Rakesh @rakez_krish]

@megclarks @ksimeono @MFMich1 @Notorious_MHC @delafuentelab @andyjminn @JHMLab @ImmunityCP Congratulations @megclarks!!

[meg clark @megclarks]

Thrilled to share our paper on how mitochondrial complex IV remodeling can modulate TAM functions and promote anti-tumor immunity! with @ksimeono, @MFMich1, @Notorious_MHC, @rakez_krish, @delafuentelab, @andyjminn, @JHMLab and those not on X! Out now in @ImmunityCP 🎉

[Immunity @ImmunityCP]

Online now: Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity https://t.co/MX1Mjl0MVX

[Penn Engineering @PennEngineers]

The immune system responds like a forest fire unless you control the spark. @raviradhak of @cbe_penn @pennbioeng and @jakebrenner of @pennmedicine decoded how protein spacing flips the immune “on” switch, paving the way for safer nanomedicine.

Read more: https://t.co/c0byxJFBEm

[Amal Narayanan @iAmNarayananLab]

We have a postdoctoral opening in the Narayanan Lab (https://t.co/OcKbTAz702) @UFChemistry @ButlerPolymer. Please apply here: https://t.co/Em0KRwGejc