Tsai-Hsuan Weng

Structural biologist @MPIbp | Exploring membrane transporter structures with cryo-EM ❄️🔬

[Tsai-Hsuan Weng @th_weng]

Thrilled to share my first paper @Nature as a postdoc @MPIbp, together with @MiChAeL_900922 @SafarianSchara, and @Claveraas @HummerLab, as well as @nguyenln_ lab. We showed how nutrients #choline & #ethanolamine are transported across membrane by #FLVCR!

[Ben Engel @bengeliscious]

The final version of our PyShell🥧🐚 paper is now online @CellCellPress. Check out how diatoms soak up 20% of the Earth's #CO2!🌏

📜 https://t.co/vm0A20XKaS

Brilliant work by @DemulderManon, @Jorgendottir, Ginga, Aki, Giovanni, Genji, Yusuke, and all the rest of our collabs 🤗

[Chia-Hsueh Lee @TheCHLeeLab]

Our work on human urate transporter is out @cell_res. @YaxinDai
single-handedly drove this project, which revealed the transport and drug mechanism of URAT1. We are grateful for the tremendous support from @StJudeStructBio

https://t.co/XBdLgxsz8G

[Beckmann Lab @BeckmannLab]

First structure of a H/ACA snoRNP acting in ribosome synthesis. In a great collaboration with the Hurt lab, we provide a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇

[Tsai-Hsuan Weng @th_weng]

@dietrich_th Congrats!

[Tsai-Hsuan Weng @th_weng]

@NoorAgip Congrats! Really beautiful work

[Max Planck Institute of Biophysics @MPIbp]

Beautiful work on the in situ structure of ATP Synthase by @dietrich_th from the Kühlbrandt group published today in @ScienceMagazine 🔬 Discover how this important protein complex shapes the inner mitochondrial membrane! 🧪

https://t.co/xoRDR7zMgJ

[Misha Kudryashev 🔬 ❄🕊️ @MishaKudryashev]

We have a new paper for you: “Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel”.

Here we found that the prototypical pentameric ligand gated ion channel can form stable tetramers and characterized it with cryo-EM/ET and molecular simulations.

[Cristina Paulino @CPaulino_]

Two open fully funded Postdoc positions in my lab in #cryoEM & #cryoET. See description below 👇Please share and spread the word. For all those interested in joining my group and work on exciting and collaborative projects please apply!
https://t.co/v3gfyQEG9T

[Murphy Lab @_Murphy_Lab]

Happy to see our study on the structure of 46-kDa Streptococcus pneumoniae NOX out in @NatureSMB! Congratulations to the authors @PABLOSANSEGUND3 and @vicsnorr 🥳
Check it out here (open-access) 👉 https://t.co/HlpklHAeYr

[Jingdong Cheng @jingdongcheng]

Together with the amazing @BeckmannLab, we have uncovered that tigecycline not only blocks A-site tRNA binding but also directly binds to the PTC on the human 55S mitoribosome. https://t.co/99cNGJSbai

[Di Wu @MiChAeL_900922]

Happy to share our latest study in @Nature revealing how FLVCR1 & FLVCR2 transport choline & ethanolamine, and shedding light on their roles in related rare diseases. Two in One! 🔬 Read more: https://t.co/hDjQDHWIa0 Great teamwork with @SafarianSchara @HummerLab @nguyenln_ 💪

[Tsai-Hsuan Weng @th_weng]

Really nice MD done by @Claveraas!

[Ainara Claveras @Claveraas]

@MiChAeL_900922 @Nature @SafarianSchara @HummerLab @nguyenln_ So glad to be part of this great collaboration! As a little add-on, here is a short movie of how choline wiggles in the binding pocket of FLVCR2

[Tsai-Hsuan Weng @th_weng]

Here is the link to the paper👇
https://t.co/HuXpmbVEFd

[Tsai-Hsuan Weng @th_weng]

Thrilled to share my first paper @Nature as a postdoc @MPIbp, together with @MiChAeL_900922 @SafarianSchara, and @Claveraas @HummerLab, as well as @nguyenln_ lab. We showed how nutrients #choline & #ethanolamine are transported across membrane by #FLVCR!

[Tsai-Hsuan Weng @th_weng]

Our cryo-EM structural analysis, which captures multiple states of #FLVCR (thanks to our great EM facility @sonjawelsch), combined with MD simulation and cellular assays shed light on the molecular mechanism of #choline & #ethanolamineare uptake into human cells.

[Max Planck Institute of Biophysics @MPIbp]

Tracking down rare diseases: Researchers from our Institute, @FraunhoferITMP, @NUSingapore, @UW & @goetheuni studied the structure & cellular function of #FLVCR proteins paving the way to understand the progression of rare diseases & develop new therapies👉https://t.co/AZF8SwkvTW

[Simon Newstead @inwardopen]

An exciting time in Solute Carrier research. Here are some of the areas where SLC structural biology is heading and where future opportunities for new discoveries and therapeutic interventions await. https://t.co/JHeCx7weEt https://t.co/UVm6apASDk @BiochemOxford @KavliOxford

[Tsai-Hsuan Weng @th_weng]

@dietrich_th @and_schwarz @NoorAgip Nice work! 🎉

[Boudker Lab @BoudkerLab]

Transporter aficionados unite! In @Nature, @OlgaBoudker and David Drew provide a comprehensive review of how secondary active transporters can couple substrate transport to ion gradients, and how lipids can regulate transport mechanisms.

https://t.co/GWcb1cRKlm