Lydia Finley

Cell biologist with an interest in pretty much everything

[Papagiannakopoulos Lab @ThalesPapaG]

Excited to share our new paper in @ScienceMagazine A subset of lung cancers drives cachexia, not through factors circulating in the blood, but through local lung sensory neurons. https://t.co/eoRLCutXG4 big thanks to first authors Michael and @s_kotschi our collaborators

[Omer Yilmaz @ohyilmaz]

Excited to share our new @CellStemCell study from @kochinstitute @MIT: "Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis." Led by two former lab postdocs—Saori Goto (first author) & Nori Goto, now running his own lab. https://t.co/NTP7cez9hb

[Karuna Ganesh @KarunaMDPhD]

We are thrilled to share our latest work out today @Dev_Cell! Appendiceal adenocarcinoma (AC) is a rare, aggressive cancer that frequently spreads to the peritoneum. Until now, lack of robust preclinical models has severely limited drug discovery. https://t.co/8rPe1G87CZ🧵👇 🔗

[Shilatifard Lab @ShilatifardLab]

Congratulations to Dr. Shimaa Soliman and colleagues in our @ShilatifardLab as they performed detailed biochemical studies of chromatin and RNAPII under normoxic and hypoxic conditions and identified hypoxia-responsive transcriptional axis linking P-TEFb, BHLHE40, and nuclear-localized Tim8–Tim13 complexes. Our study shows that chromatin-associated interaction is required for efficient hypoxic gene transcription and operates at least partly independently of canonical HIF signaling. Disrupting Tim8–Tim13 or silencing BHLHE40 impairs acute hypoxia responses. These findings identify a new regulatory mechanism coordinating RNAPII pause release during hypoxic stress. #Hypoxia #Transcription #CancerBiology #RNApolII #PTEFb @NU_BMG_SQE @CellPressNews @ScienceMagazine @ScienceAdvances @Nature @NatMetabolism @MolecularCell @NUFeinbergMed https://t.co/dXk0Zxp74a

[Kelsey Fisher-Wellman, PhD @KFW_Lab]

New review from our group taking a critical look at OxPhos as a cancer target......and suggestions for where the field goes next. Published in @Biochem_Journal
https://t.co/rwU1AIymEK

[Lydia Finley @lydfinley]

AND to our newest @GSKGradSchool student in the lab, Monika Komza, on her fellowship award! Feeling grateful to spend an afternoon celebrating the amazing scientists who move through our labs and on to new horizons!

[Lydia Finley @lydfinley]

“Uncertainly isn’t a flaw in what we do. It is what we do.”

Check out Juliana Delgado’s commencement speech @MSKCancerCenter

An ode to becoming a scientist. A reminder that questions are power, doubt is discipline, and the journey really is the point 🌟https://t.co/VC3coXhUdw

[Lydia Finley @lydfinley]

Overall, yesterday was really special day @MSKCancerCenter celebrating @GSKGradSchool graduates, including our very own Abby Xie!! Congratulations Dr. Xie!

[Lucas Sullivan @LucasBSullivan]

New out this week from our lab in @NatMetabolism. We measured dynamic aspartate changes following mitochondrial inhibition, finding that SDH inhibition causes a counterintuitive rebound effect mediated by succinate impairing pyrimidine synthesis.

https://t.co/Hk8FmhOgf1

[Eddie Rashan @EdreesRashan]

Check out our Spotlight in @MolecularCell on @lydfinley lab's recent work on Aconitase 2 and its protective role against impaired cell fitness and ISR activation due to mitochondrial citrate accumulation https://t.co/PBU4RjjN9O

[The Company of Biologists @Co_Biologists]

Thank you to organisers Lydia Finley @lydfinley and Wilhelm Palm @WilhelmPalm and everyone who joined us at this week's Workshop on 'Revisiting Metabolic Fundamentals'
https://t.co/4OgDKkafoY
#BiologistsWorkshops

[Mara Sherman Lab @MaraShermanLab]

@shouval_lab @SnehaPramod @hagargir and I reflect on the work of the ✨ TME community in a new review re fibroblasts in cancer @NatureCancer. 2025 was my yr to 🩵 the distraction of writing (IYKYK), so thx to all whose discoveries made this so gratifying. https://t.co/9nNnkvh3wX

[Gad @gadmark]

Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. https://t.co/hhsiYw1jXB 🧵 1/9

[Lucas Sullivan @LucasBSullivan]

Pleased to share our recent work out today in @NatMetabolism. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?

[Lyssiotis Lab @LyssiotisLab]

🗽Another inspiring Cancer Metabolism and Signaling Symposium @NYASciences. Thanks to the speakers & participants!

@lydfinley @RichPossemato
@lab_manning @bensahralab @MarcusDGon @airdlab @KanarekNaama @JaviGBermudez @SantoshVardhana, et al

You would have enjoyed it, Steven. We missed ya ✌🏼

[Lydia Finley @lydfinley]

@longlabstanford @NatMetabolism @DrYongXu1 @Shuke_Xiao So cool!! (As always!!) Huge congrats!!

[Long Lab @longlabstanford]

The first approved GLP1 (Byetta) came from a desert reptile, the Gila monster. Inspired by this, our work on Burmese pythons 🐍🐍 is now out @NatMetabolism. An “extreme”-ly fun collaboration with Leinwand and @DrYongXu1. Congratulations @Shuke_Xiao!
https://t.co/Qwqd71JQYb

[Richard Possemato @RichPossemato]

I’m excited to share new work out of the lab at @NYULangone led by @kenjifujihara! We took a first principles approach to evaluating #ferroptosis induction for cancer therapy via targeting the SLC7A11-glutathione-GPX4 axis. https://t.co/aygUUltHhq

[Nature Metabolism @NatMetabolism]

#NatMetabPicks | In @CellCellPress led by @lydfinley (@mskcancercenter)

Citrate clearance is an essential function of the TCA cycle via the activity of aconitase 2.

https://t.co/oGNcFOffEm

[Judith Agudo @JudithAgudo1]

Metastasis kills most cancer patients and grows from invisible seeds. How do these seeds escape from attack by immune cells? These seeds harness stress hormones!🤯
⁦thanks to ⁦@nyscf⁩ ⁦@parkerici⁩ for their support. Today at ⁦@Nature⁩ https://t.co/rMKnHEqQwb