Mals Mariappan

[Dan Hebert @hebERt_lab]

Checkout the recent work from our lab that demonstrates how glucose attached to a protein can direct the protein folding and molecular choreography of nascent chains in the endoplasmic reticulum.

[Ishier Raote @ishier_raote]

Nice reconstitution from @MariappanLab. Nascent proteins from stalled ribosomes are polyubiquitinated and then promptly deubiquitinated, giving a second chance to fold. If a protein still can't fold, it exposes a degron, is re-ubiquitinated and degraded.
https://t.co/Bi2FuE3itc

[Mals Mariappan @MariappanLab]

We report that nascent chains ubiquitinated on stalled ribosomes undergo complete deubiquitination upon release from ribosomes. Deubiquitinated proteins can fold into mature proteins or be re-ubiquitinated in the cytosol for degradation if they misfold.

[Mals Mariappan @MariappanLab]

Nascent Chain Ubiquitination is Uncoupled from Degradation to Enable Protein Maturation https://t.co/dPXt3W67bg

[Markus Höpfler @MarkusHopfler]

We usually think of mRNAs carrying the information needed to make a protein (the central dogma...). But how can the encoded protein control the fate of its encoding mRNA? 🤔
Check out our review on the topic 👇
https://t.co/vqj5JHzWbJ

[WilsonLab @WilsonLab2]

Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control: Cell https://t.co/NvxpX560bI

[Markus Höpfler @MarkusHopfler]

🚨Out now!🚨 Check out how cells adjust their tubulin mRNA levels in response to excess free tubulin. A 40-year-old puzzle solved! Wonderful collaboration with @AbsmeierEva, @lapassmore & @Ivana_Gasic 🧵 1/
https://t.co/FrlnvtIlLR

[Beckmann Lab @BeckmannLab]

🎉We are thrilled to share our exciting new collaboration with @inada_lab and @jingdongcheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:👇 #ribosome #ubiquitin #cryoEM

[Kapil Ramachandran @KVRamachandran5]

A beautiful story from @LukeChaoSun and @erin_schuman on how 19S proteasome caps can independently regulate aspects of synaptic biology. lovely to see it out!! https://t.co/t9nWNysIoY

[Mals Mariappan @MariappanLab]

Very nice paper from the Zhang group

[Mals Mariappan @MariappanLab]

UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1... https://t.co/Q290ikRMRo

[Frydman Lab @FrydmanLab]

Check out the preview of our latest story at https://t.co/mFw9rHYD7T

[James Olzmann @OlzmannLab]

New work from Ron Kopito and @scafrancesco1 reveal that UFMylation of ER translocon-bound 60S ribosome subunits promotes proteasome-mediated degradation of arrest polypeptides following ribosome stalling. 👏 https://t.co/CdoFQ2YhbJ

[Journal of Cell Biology @JCellBiol]

.@udi_yael et al. @RoutLab_RU @RockefellerUniv present a new method for quantitative subcellular fractionation of a wide range of mammalian cells while maintaining nuclear integrity. https://t.co/k38m6oGQ3F

@innalax
#Biochemistry #Trafficking #Organelles

[Chris Incarvito @cincarvito]

Multiple job opportunites in the @YaleWestCampus Cores - mass spec & flow cytometry. Join an established team of staff scientists in support of research across campus. Please RT

https://t.co/B33McAZFMN

#research #hiring #yale @YWCimagingcore

[Mals Mariappan @MariappanLab]

Yale Cell Biology Seminar Series: "Molecular Origami: The Delicate Art of Protein Folding and Misfolding and Its Relevance to Health and Disease" https://t.co/DScc0BfGbe via @yalemed

[Kallol Gupta @GuptaLab1]

Honored & excited to be selected for Best of @BiophysJ symposium @BiophysicalSoc #BPS2023 Shout out to @MariappanLab & @MoitrayeeLab for their pivotal contributions @YaleCellBio
https://t.co/oU3zbseGDW

[Art4Science @rimatesa91]

This week's fanart is by Sha Sun, Xia Li, and Malaiyalam Mariappan
°
#biology #research #cell #compbio #ER #structural #protein #folding #communication #sciart

[Mals Mariappan @MariappanLab]

@rakri_sathish Thanks Sathish

[Mals Mariappan @MariappanLab]

The Get1/2 insertase forms a channel to mediate the insertion of tail-... https://t.co/F5dyrliIn6

[Mals Mariappan @MariappanLab]

@OlzmannLab Thank you, James