Havell Markus

Rising M4 MD/PhD Candidate @PennStHershey | Applying #RadOnc for 2027 Match | Alum @ASU @Cambridge_Uni | Bridging GWAS & multi-omics with clinical oncology 🧬

[Havell Markus @MarkusHavell]

Excited to share a part of my PhD thesis! We developed a novel method to predict the risk of progression from pre-clinical to clinical disease for SLE and RA. So thankful to my co-first author @ChenWang_PSU and mentors @dajiangliu81 and Dr. Bibo Jiang

[Dajiang Liu @dajiangliu81]

I am happy to share our new work that predicts the progression of autoimmune diseases, integrating EHR and GWAS datasets @NatureComms . https://t.co/81WRL7oalS

[Mukund Iyengar @mukundiyngr]

What did ASCO 2026 change?

Some standards of care have now moved by years.
That almost never happens.

BRAF colorectal, pancreatic KRAS, and DDLPS sarcoma
are three of oncology's hardest diseases

SOC moved by > 1yr:
▫️BRAF mCRC: 15.1 → 30.3 months OS
▪️Pancreatic KRAS: 6.7 → 13.2 months OS 🏆
▪️DDLPS sarcoma: 1.5 → 9.7 months PFS ⭐️
(sarcoma went from "nothing" to a win).

Myeloma, GIST, HR+/HER2- breast, uveal melanoma, bladder, prostate, and RET+ lung cancer moved too.

This is what decades of funded science look like when it compounds.

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Source: Jori (@jori_health)
𝘗𝘭𝘰𝘵 𝘱𝘦𝘦𝘳-𝘳𝘦𝘷𝘪𝘦𝘸𝘦𝘥 𝘣𝘺 𝘦𝘪𝘨𝘩𝘵 𝘰𝘯𝘤𝘰𝘭𝘰𝘨𝘺 𝘦𝘹𝘱𝘦𝘳𝘵𝘴. 𝘛𝘩𝘢𝘯𝘬 𝘺𝘰𝘶 <3
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[Havell Markus @MarkusHavell]

@FSamaan Congratulations!!

[Pooja Middha @PoojaMiddha21]

Excited to share our new paper investigating the role of a generalised autoimmunity polygenic risk score on cessation of immune checkpoint inhibitor therapy for toxicities. @rohit_thum @ziv_elad @AdamJSchoenfeld @MelindaAldrich @christine_lovly @UCSFCancer @UCSFMedicine

[Science Magazine @ScienceMagazine]

A massive @ScienceAdvances study involving weekly data from more than 300,000 pregnancies offers a new look at dynamic physiological changes and complications. https://t.co/FYuKOwv2bd

[Havell Markus @MarkusHavell]

I'm excited to share a wonderful collaboration with @LD_matrix: JOBS integrates bulk and single-cell eQTLs to boost eQTL discovery. Integrated with GWAS, it identified more disease-linked loci for 14 immune disorders &amp; fueled drug-repurposing. #immunology #drugdiscovery #genomics

[Dajiang Liu @dajiangliu81]

I am excited to share our new work that generates a single cell eQTL atlas for immune cell types. The work integrates bulk eQTLs with sc-eQTLs, which boosts the power for identifying sc-eQTLs for up to 4 folds. As such, we have the power equivalent to sc-RNASeq of 4K individuals.

[Dajiang Liu @dajiangliu81]

I am excited to share our new work that generates a single cell eQTL atlas for immune cell types. The work integrates bulk eQTLs with sc-eQTLs, which boosts the power for identifying sc-eQTLs for up to 4 folds. As such, we have the power equivalent to sc-RNASeq of 4K individuals.

[Roychoudhuri Lab @RoychoudhuriLab]

Thrilled to share new work led by @JieYang437 in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre https://t.co/dO2v0GWKAn

[Nick Banovich @NeBanovich]

Super excited to share our most recent work! Heart transplant rejection was a new area for me, but it's a disease I care deeply about. As some of you know my dad passed unexpectedly from heart failure in Oct. 2020 only a few days after he was informed he needed a transplant.

[Faisal Mahmood @AI4Pathology]

So exciting to see that PathChat published in @Nature last summer (https://t.co/OAIG31ofWJ) has now received FDA Breakthrough Device Designation. Likely one of the first generative AI tools for pathology to receive the designation. We are well on our quest to having a single MLLM answer any question about human pathology! Congratulations to our superstars who worked on this project @richardjchen @MYLu97 @DFKW_

[YukinoriOkada @okada_yukinori]

📢Blood DNA virome🧬🦠 assocites autoimmune diseases🔬. Endogeneous human herpesvirus 6B (eHHV-6B) has systemic lupus erythematosus (SLE) risk. Increased anellovirus in SLE, rheumatoid arthritis (RA), COVID-19 @NatureGenet📰#wgs #lupus #virus #covid #gwas
https://t.co/g7qIVvgYyS

[Nick Banovich @NeBanovich]

Excited to see this study published! Great work that was co-led my Niran Hadad from my group. https://t.co/xFxmK0LCPm

[Marios Georgakis @MariosGeorgakis]

Polygenic risk scores (PRS) are mostly trained on clinical endpoints. Remains unknown if they associate with subclinical pathologies🧬

This paper on Alzheimer's disease shows associations of a PRS with longitudinal imaging and memory changes🧠📉

📜: https://t.co/HH3A1RpJJr

[Nicholas Fabiano, MD @NTFabiano]

Handwriting leads to widespread brain connectivity - typing does not.

🧵1/10

[Neil Renic @NC_Renic]

First person in the family to become an academic:

Cons:
- No money
- No investments
- Questionable career prospects
- Wearing a backpack

Pros:
- more peer-reviewed articles than siblings

[Rafael Irizarry @rafalab]

🚨 We're hiring! 🚨

Join us at @HarvardBiostats and @dfcidatascience

We are filling THREE positions:

1️⃣ Tenure-track (any rank) in AI/ML
2️⃣ Assistant Professor in Single Cell Genomics
3️⃣ Lecturer &amp; Director Training/Education

Need to apply separately for each role. Links 👇

[Dajiang Liu @dajiangliu81]

Please RT to raise some awareness for @AllofUsResearch users.

[Sarah-Jane Dawson @SarahJ_Dawson]

Thrilled to share our new paper! Congratulations @SHollizeck⁩, Ning Wang, ⁦@dineika_chandra⁩ who led the work ⁦@TheDawsonLab⁩ ⁦@PeterMacRes⁩ ⁦@GenCancerCentre⁩

Unravelling mutational signatures with plasma circulating tumour DNA https://t.co/EqHEfJsWWf