Mordes Lab

Integrating neuropathology, stem cells, and multi-omics to study neurodegeneration #ALS #dementia @UCSFPath @INDUCSF 🧠🔬🌻

[Mordes Lab @MordesLab]

Huge congrats to @JulieSmeyers for being awarded a Springboard Fellowship from Target ALS!

https://t.co/betguo8Z8p

[Mordes Lab @MordesLab]

Excited to share our @CellReports article! We investigated how the loss of TBK1 function contributes to ALS and dementia using human stem cell-derived neurons and advanced proteomics. Many thanks to all co-authors for their great work and collaboration!

https://t.co/kQUVtI0GCq

[ShorterLab @ShorterLab]

Regulation of translation elongation and integrated stress response in heat-shocked neurons: Cell Reports https://t.co/ZtyMekUasN

[ShorterLab @ShorterLab]

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: https://t.co/RgVZYiIy1u

[Mordes Lab @MordesLab]

In this study, we observed that a C9ORF72-ALS/FTD dipeptide repeat protein perturbs the phosphorylation of RNA binding proteins and STMN2 expression, and found that SRSF7 sustains STMN2 levels in induced neurons. Congrats to @JulieSmeyers and Karen! #ALS

https://t.co/Hr57fyZTbF

[Nowakowski_Lab @LabNowakowski]

Excited to share new study from the lab, work led by @JohnPAndrews_MD and grateful for all the collaborators who made this possible including @ChangLabUcsf @ucscgenomics

[Rothstein Lab @Rothstein_Lab]

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes

https://t.co/tLvIDdc4s2

[Mordes Lab @MordesLab]

Had a great time at the Oktoberfest IND collaboration hour! Thanks to everyone who stopped by.

[FrattaLab @FrattaLab]

Out @ScienceMagazine! New tech to activate ALS gene therapies only in the right cells at the right time - Increased safety to have more options for ALS.
We do it by taking advantage of cryptic splicing.
https://t.co/tPNurQJREV
@UCLIoN @TheCrick @OscarWilkins16 @MaxZYJChien

[Mordes Lab @MordesLab]

Excited to announce new funding from the NIA to investigate the connection between defects in protein homeostasis and neurodegeneration. #FTD #dementia #ALS

[Mordes Lab @MordesLab]

Had a lot of fun at lab lunch! Welcome to the lab, Nicole and Lisa!

[Mordes Lab @MordesLab]

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing https://t.co/GdLwLoHbKR

[Target ALS @TargetALS_fdn]

The Target ALS #DataEngine just got bigger!

We’ve expanded datasets across all core collections, added a user manual, and released new demo videos. Now it’s easier than ever to explore and utilize rich data for #ALSResearch.

Explore the updates: https://t.co/r0WkF5OQSI

[Vik Khurana Lab @khurana_lab]

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions: Neuron https://t.co/ahNbLNkQiU

[Francesco Limone @ScienceLemon92]

Excited to finally share work from a past life! In this small study we dissect neuronal vulnerability, myelin dysfunction and microglia activation in #ALS read our full work on @NatureAging
https://t.co/4Syvdw8qEc

[Jennifer Yokoyama @YokoyamaLabUCSF]

Check out the data that goes along with our new manuscript & conduct an exciting secondary analysis of your own! @RCFNeuro @alzdemjournals

[Martin Kampmann @MartinUCSF]

Excited to share this review on one of my favorite biological problems:

Selective vulnerability in neurodegenerative disease, and how recent technologies are yielding new insights into the underlying mechanisms.

Out in @NatRevNeurosci today!

https://t.co/LlM2SkcaSe

[Mordes Lab @MordesLab]

Exciting study from the Gitler Lab: TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes https://t.co/EFIqe0yCFr

[Adrian Isaacs @isaacs_adrian]

Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by @AshlingGiblin and @AlexCammack https://t.co/NIm2FmGZV5 1/9

[Institute for Neurodegenerative Diseases @INDUCSF]

Are you an incoming UCSF grad student interested in doing research in neurodegeneration? If you are, join us at the IND OPEN HOUSE @ Helen Diller on 11/15 to meet our current trainees and faculty and to discuss their research!

Register here: https://t.co/bcvEjE1hKQ