OWL

One World Lab offers $50 antibody aliquots only from original manufacturers for affordable validation.

[OWL @OneWorldLab]

@davidasinclair An initiative has started to create more rewards, recognition, relationships and reproducibility in research. It’s called https://t.co/na80LcPpQd.

Yet changing behavior, even when it has health consequences, is beyond challenging. Especially when it’s systemic.

[OWL @OneWorldLab]

Every time this happens it reinforces that the research community must take action.

Waiting for a new administration is not the solution.

The nascent work at https://t.co/SsqoGBOh2v is the only self funding mechanism based on research as proof.

Don’t wait!

[Emma J Chory @chorye]

This is what the future of American science looks like, and frankly, it is bleak.

https://t.co/rhL6W4eIyv

[OWL @OneWorldLab]

@Nature An alternative funding mechanism generated by researchers themselves is what has been proposed by a scrappy young startup https://t.co/na80LcPpQd.

[OWL @OneWorldLab]

@paulkhls @peptai_ Any meetup happening in mid June?

[OWL @OneWorldLab]

@pdhsu Someone slipped you some psilocybin 🍄

[OWL @OneWorldLab]

@GolatoTyler The video is supercool!

[OWL @OneWorldLab]

@Nature GATACA

[OWL @OneWorldLab]

@AgingBiology Did data stop Theranos from reaching a multi billion dollar valuation?

[OWL @OneWorldLab]

@TomBixby4 @davidasinclair More like 6-7 years, but I “see” what you’re doing.

[OWL @OneWorldLab]

@davidasinclair @sinclairfriends Still rocking that same denim shirt, which also looks great for its age!!

[Patrick Hsu @pdhsu]

Here's the paper itself. If you're interested in joining the team to turn this into a medicine, please reach out https://t.co/O9YTLpQ1TE

[OWL @OneWorldLab]

Must highlight a future Nobel prize

[Patrick Hsu @pdhsu]

Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome.

The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited.

The problem with CRISPR is that it cuts up your DNA, and then hopes that unreliable cellular DNA repair will make the wanted edit. @geochurch famously called it genome vandalism. More precise versions of CRISPR only edit less than 100 bases - often only a single base. Therefore, it's not suited to make large changes safely.

However, most diseases are not the result of mutations in one location. Instead, their causes are spread all across the 3 billion base pairs in the genome.

We found bridge RNAs in bacterial “jumping genes” that allow us to make safe and arbitrary changes (insert, cut out, or flip) to every nucleotide within (up to) a 1 million bp sequence in your DNA.

In the paper, we show that we can correct the disease-causing DNA repeats that cause Friedreich's ataxia (which is a rare neurological disease). The same approach could be applied to Huntington’s and other repeat expansion disorders.
At @arcinstitute, we're working towards a full Turing machine for biology. Evo, our DNA foundation model, helps us design the optimal healthy DNA sequences. And Bridge recombination gives us the ability to seamlessly write these changes into the right place in the genome.
This work was a wonderful collaboration with my @arcinstitute cofounder @SKonermann and led by the indefatigable @ntperry13, alongside our amazing bridge editing team: @BartieLiam @dhruvakatrekar @Gabogonzalez515 @mgdurrant @james_jw_pai @AlisonFanton Juliana Martins Masa Hiraizumi @chiaroscurale @hnisimasu

[OWL @OneWorldLab]

@davidasinclair How about making access to the plants legal, instead of only synthetic derivatives under patent protection? And if derivatives are legal then why not include ergots derivate Lysergic Acid Diethylamide to the list?

[OWL @OneWorldLab]

What is the sci-fi movie that will come from this?

[David Sinclair @davidasinclair]

Harnessing the epigenetic rejuvenating properties of stem cells in flatworms & mice could us reverse aging in humans

[ChainReaction @ChainRctnGlobal]

Scientific research is broken.🧪

@erinmagennis , co-founder of @MuseMatrix_ , explains the funding game is monopolised by governments & legacy institutions. 🏰

DeSci flips the model - decentralizing participation, funding & access to research.

👉This is part 1 of our @erinmagennis voices of web3 interview.

Follow @ChainRctnGlobal to learn more.

🎥Shot by @samiwanczak

[OWL @OneWorldLab]

@D1ckDAO Is there a bar graph % probability vs # events? At 96 you have a 69% lower risk! “Bust a Nut in Cancer’s Guts” should be the name of the study.

[David Sinclair @davidasinclair]

NEW PAPER: Partial reprogramming with virally-delivered OSK genes rejuvenates senescent cells, restores tissue integrity, heals wounds & extends lifespan in mice. Can't wait to see if it works in humans @lifebiosciences 🚀 https://t.co/O7ANo5BDO2

[Solana @solana]

Accelerate permissionless science on Solana 🧪

Big shoutout to everyone who joined us at the DeSci Fair in NYC!

[ResearchHub @ResearchHub]

Apply for funding and fund promising research.

[Patrick Joyce @joycesticks]

Join us for a chat about funding novel science using preregistrations on @ResearchHub