Top Tweets for #harmoni2
👑 Has King Keytruda finally met its challenger?
HARMONi-2 | PD-L1 TPS ≥1% | 1L advanced NSCLC
• PFS: HR 0.51
• OS: HR 0.73
PD-1 × VEGF — ivonescimab beat pembrolizumab in HARMONi-2.
#MVOnco #WCLC2026 #HARMONi2 #NSCLC #LungCancer #Ivonescimab #Pembrolizumab
🚨🔥@OncoAlert Hot off the press.
#BigNews #PressRelease by @SMMT_TX
⭐️ #HARMONi2 phase 3 trial of 1st line #Ivonescimab vs #Pembrolizumab in pts with #PDL1+ advanced non-small-cell #LungCancer (which previously showed #PFS benefit) now showing:
✅Statistically Significant ⬆️
#OverallSurvival (#OS) Benefit
👇🏻
https://t.co/CQejBTqLn3
🚨🔥@OncoAlert Hot off the press
Just published @TheLancet
Results of #HARMONi2 phase 3 trial of #Ivonescimab (#PD1 & #VEGF Ab) vs #Pembrolizumab in pts with #PDL1+ advanced non-small cell #LungCancer in China.
⬆️#mPFS: 11.1 vs 5.8 months #HR: 0.51
👇🏻
https://t.co/I2qVjQ0u6M
🚨🔥@OncoAlert Hot off the press
Just published @TheLancet
Results of #HARMONi2 phase 3 trial of #Ivonescimab (#PD1 & #VEGF Ab) vs #Pembrolizumab in pts with #PDL1+ advanced non-small cell #LungCancer in China.
⬆️#mPFS: 11.1 vs 5.8 months #HR: 0.51
👇🏻
https://t.co/I2qVjQ0u6M
New era for bispecific drugs in Oncology #HARMONi2
🚨🔥@OncoAlert Hot off the press
Just published @TheLancet
Results of #HARMONi2 phase 3 trial of #Ivonescimab (#PD1 & #VEGF Ab) vs #Pembrolizumab in pts with #PDL1+ advanced non-small cell #LungCancer in China.
⬆️#mPFS: 11.1 vs 5.8 months #HR: 0.51
👇🏻
https://t.co/I2qVjQ0u6M
🚨🔥@OncoAlert Hot off the press
Just published @TheLancet
Results of #HARMONi2 phase 3 trial of #Ivonescimab (#PD1 & #VEGF Ab) vs #Pembrolizumab in pts with #PDL1+ advanced non-small cell #LungCancer in China.
⬆️#mPFS: 11.1 vs 5.8 months #HR: 0.51
👇🏻
https://t.co/I2qVjQ0u6M
Lung Ca Highlights #WCLC24 w/ @GlopesMd @SylvesterCancer
- #CM77T vs #CM816
- #SKIPPirr
- #HARMONi2
- #TROPIONLung01
Full Int:
- https://t.co/JtLxjrJNFK
- https://t.co/iL4Q6icxIL
- Also on the “Oncology Brothers” podcast
#lcsm #OncTwitter #MedTwitter @TargetedOnc @IASLC
1. #HARMONi2: 1L #ivonescimab (PD1/VEGF bispecific) mNSCLC PDL1 ≥ 1% vs Pembro alone.
- mPFS of 11.14 vs 5.8 mos
- ⬆️ PFS for PDL1 ≥ 50% (HR: 0.46)
- ⬆️ PFS for PDL1 1-49% (HR: 0.54), but SoC is Pembro + Chemo (🚫 single agent Pembro)
- 🇨🇳 only study, will need 🌎 study
2/7
#WCLC24 Highlights #CommunityOncology:
1. #HARMONi2 in mNSCLC
2. #CM77TvsCM816 resectable NSCLC
3. #TROPIONLung01 in 2L mNSCLC
4. #SKIPPirr: AEs for Amivantamab
5. #TNM staging: 9th Ed
6. Personal highlights
#lcsm #OncTwitter @IASLC
1/7
#HARMONi2: PD-1/VEG-F bispecific antibody #Ivonescimab vs #pembro, at #WCLC2024, improved PFS and acceptable tox. ?next big thing… OS data and international trials surely to follow
Fantastic discussion of #WCLC24 highlights. Including promising ivonescimab results from #HARMONi2 offering hope for #EGFR+ #LungCancer pts who’ve progressed on TKIs. 🙏 @StephenVLiu, @marinagarassino @MattSmeltzer & the panel - an excellent listen. #LCSM
https://t.co/woTwKt3s7M
HARMONi-2: n=398 wt pts PDL1+. Pembro 200 vs Ivonecscimab. 1o=PFS(BICR). HR=0.51. Benefit across PDL1 & histology. TRAEs relatively low. No deterioration in QLQC30. Jawdropping PFS benefit. OS waited but surely will be positive. Congrats @AkesoInc
#WCLC24 Dr John Heymach @MDAndersonNews asks if we are ready to disrupt the harmony in 1L chemoIO options? Providing a well balanced critique of the #HARMONi2
➡️ Why did the pembro control arm underperform?
➡️ Would this PFS benefit extend to OS?
@OncLive takeover @Latinamd
🔥🚨@OncoAlert HOT OFF THE PRESS.
Just presented at the presidential symposium @IASLC #WCLC24
Results of #HARMONi2 trial of
#Ivonescimab VS #Pembrolizumab in advanced non-small cell #LungCancer with PD-L1 >1%.
✅ Significant ⬆️mPFS
11.14 vs. 5.82 months (HR 0.51)
#Benefit in:
✅PD-L1 low (1-49%) & High (>50%)
✅Squamous or Non-Squamous
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