Alok Jaiswal

Scientist@ The Broad Institute of MIT & Harvard, Studying Chronic inflammatory diseases, Fibrosis, Food Allergy. Data muncher 🇳🇵🇮🇳 🇫🇮 🇺🇸

[Cell Genomics @CellGenomics]

Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases https://t.co/NVDvdi8XRO

[Broad Institute @broadinstitute]

Newly uncovered pathway behind tissue scarring, or fibrosis, in inflammatory bowel disease suggests new treatment strategies for the dangerous condition. https://t.co/6Mw7lMmAPD

[Alok Jaiswal @jaiswal_ok]

A very nice thread of our study out in @Nature on dissecting the cellular and molecular circuitry driving Fibrosis in the Gut; led together with @vladpokatayev. It was a humongous effort by the team, and especially thankful to Ramnik Xavier and Dan Graham for supporting us

[Vlad Pokatayev @vladpokatayev]

Fibrosis drives ~50% of disease deaths, yet anti-fibrotics are limited. In our @Nature study we combine single-cell + spatial profiling of IBD patients with functional genomics to map a pro-fibrotic cell circuit centered on GLIS3. https://t.co/V49d2l3caS

[Nature Reviews Methods Primers @MethodsPrimers]

Small economies with limited resources encounter a number of challenges in addressing research and development needs. @adhakal, @phutungri and @rajbhandari_33 share their attempts to face these challenges in Nepal in this Comment

https://t.co/eNKwNUElY2

[Xavier Lab @TheXavierLab]

New in @NatImmunol! We identify pH sensor GPR65 as a controller of tissue inflammation in vivo and reveal functions of the I231L #IBD risk variant in multiple immune cell populations using newly-generated knock-in mice. 1/3 https://t.co/q3kUobZK3v

[Alok Jaiswal @jaiswal_ok]

@tuomohartonen @JuliaZeitlinger Congratulations Dr. Tuomo!

[Alok Jaiswal @jaiswal_ok]

@epietilae @ZanivanLab @PiviOjala4 @LehtiLab @helsinkiuni @HelsinkiUniMed Congratulations @epietilae 🎉🎉

[Xavier Lab @TheXavierLab]

Out now in @PLOSBiology! Guadalupe Jasso and @jaiswal_ok et al. generate a single-cell transcriptomic atlas of the intestinal stromal compartment in mice. (1/3)

https://t.co/lE5cYXaV9f

[PLOS Biology @PLOSBiology]

Single-cell transcriptome of mouse intestinal stromal compartment identifies inflam-associated fibroblasts producing IL-11 & mucosa-associated fibroblasts expressing Adamdec1, needed for tissue remodeling during #colitis @TheXavierLab &co #PLOSBiology https://t.co/e9G8fGSp10

[Xavier Lab @TheXavierLab]

Out today in @cellhostmicrobe! In work led by @ericmichbrown and @HASCiencia we show that ADP-ribosyltransferases are phage-associated proteins plentiful in commensal bacteria in the human gut microbiome & confer fitness advantages in the gut. (1/4) https://t.co/NSyjCNFG6S

[Xavier Lab @TheXavierLab]

In a collaboration with Kenya Honda’s lab to characterize gut microbiomes of centenarians we identified a novel biosynthetic pathway producing a potent antimicrobial 2° bile acid that may contribute to healthy aging. @DamianPlichta 👋
https://t.co/aRWzWlqYOJ

[Xavier Lab @TheXavierLab]

Out today in @CellReports! We show that counter-regulation of lipid membrane dynamics by mammalian host cells and bacteria during xenophagy modulates an innate defense response (1/6):

https://t.co/TPcyIUHdMk

[Xavier Lab @TheXavierLab]

Congrats Bernard! An elegant example of the use of chemical immunophenotyping to uncover mechanisms regulating the balance between tolerance and inflammation https://t.co/kV3l9AbgQC

[Xavier Lab @TheXavierLab]

We are looking for postdoctoral researchers w/PhD degrees in molecular biology, biochemistry, immunology or computational biology.

Come join a dynamic team of scientists working on cutting edge research in microbiology, immunology, and more!

APPLY HERE: https://t.co/p98Iq81MuW

[Alok Jaiswal @jaiswal_ok]

Elated to see this published! work done during my PhD at @FIMM_UH And great collaborators @LehtiLab @WennerbergLab

[Mol Syst Biol @MolSystBiol]

CLIP: a #MultiOmics data integration method that combines #cancer cell line #omics data from multiple studies & identifies cancer cell line-specific genes --> https://t.co/c2djhTHmXF from T Aittokallio @helsinkiuni @jaiswal_ok @broadinstitute

[Alok Jaiswal @jaiswal_ok]

Once-Weekly Semaglutide in Adults with Overweight or Obesity | NEJM https://t.co/MvJXmyVSyo

[Ruslan Medzhitov @RMedzhitov]

Most disease have normal physiological counterparts. Here is our views on food allergy from ecological and physiological perspectives.
Should be accessible at this link.

https://t.co/hakWy5Ug3N

[Christopher Smillie @cssmillie]

The Smillie Lab opens March at @MGHMedicine! We develop methods (wet/dry) to understand microbial life on the human body #microbiome #singlecell #evolution #deeplearning. Hiring grad students, postdocs, and RAs @harvardmed @broadinstitute. Please share! https://t.co/uKyEHqvaLe

[Alok Jaiswal @jaiswal_ok]

A very nice tweetorial 👇 of this great work! and glad to contribute

[Xavier Lab @TheXavierLab]

How do ER stress response pathways maintain cell survival and function in health and disease? Out now @Sciencemagazine, we identify an arm of the PERK-eIF2α UPR pathway that determines cell fate during #ERstress.

https://t.co/nf1YSfEQ9y

[Nature Biotechnology @NatureBiotech]

A multicenter study benchmarking single-cell RNA sequencing technologies using reference samples https://t.co/22QViNaR6J