Nick Saner

PhD | sleep | exercise | mitochondria

[Esther García-Domínguez @Esther_GD_]

I’m thrilled to share one of the studies from my PhD, which has just been published in @PNASNews 🤗

“Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans”

🔗👇🏼

https://t.co/k97dhmKfhf

[William A. Wallace, Ph.D. @WilliamWallace]

Controlled sleep restriction studies consistently show the same pattern: restrict healthy adults to 4-6 hours a night, and within a week, cortisol, glucose tolerance, insulin sensitivity, muscle protein synthesis, appetite hormones, and testosterone all move in the wrong direction. No single marker tells the story. The tax is cumulative.

Leproult & Van Cauter, JAMA, 2011; Buxton et al., Diabetes, 2010; Spiegel et al., Lancet, 1999; Saner et al., J Physiol, 2020; Zuraikat et al., Diabetes Care, 2024

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

Our latest work in @natureComms, led by @javi_iup: Sprint exercise disrupts mitochondrial ultrastructure, driving a unique mito stress response & remodelling in men https://t.co/vfhUZgejMs supports targeted exercise prescriptions to achieve specific mito adaptations.
Thread 🧵👇🏽

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

Exercise Intensity Terminology is a bit of a mess 😵‍💫
Our attempt to try & summarise some of the different approaches, and make some recommendations going forward, has finally been published in both MSSE: https://t.co/iHdsdK4Mhx & JSaMS: https://t.co/ONLEM5g8U8.

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

Excited to share our latest pre-print: https://t.co/9mxteYPW5h
“Exercise induces time-dependent but not sex-specific transcriptomic changes in healthy human skeletal muscle”
Led by @DaleFTaylor with @LizReisman, @bluebirdi, @Romain_Barres, @NolanJHoffman & @JohnAHawley

🧵 1/9

[Matt Lee @matt_lee1]

🚨📰Our paper: "Delaying post-exercise carbohydrate intake impairs next-day exercise capacity but not muscle glycogen or molecular responses" is now available:
https://t.co/7Womi6c8AB
Huge thanks & congrats to @JavierDiazLara1 @LizReisman @javi_iup @LouiseMBurke @BlueSpotScience

[Liz Reisman @LizReisman]

It’s finally here 🎉🙌. Extremely proud of this piece of work published in @NatureComms

https://t.co/GusZBBGpuV

Grateful to everyone who has been involved 🙏 @javi_iup @bluebirdi @BlueSpotScience @enzo19_huang @thestroudlab @RalfSchittenhe1

[Nick Saner @NickSaner]

@BlueSpotScience Thanks Dave!

[Nick Saner @NickSaner]

@FornasierSantos @BlueSpotScience Thanks @FornasierSantos
Hope you’re enjoying the Olympics!

[Liv Knowles @LivKnowles1]

This is the 2nd paper from my PhD, and came with an award for the best article published in the July special edition of @PhysiologicalG: Integrative physiology & translational omics of exercise & physical activity 🏅

A big thanks to all authors involved. Check it out below!

[Nick Saner @NickSaner]

It’s been an incredible few weeks visiting @INSEP_PARIS (as part of the PHC FASIC program) to see the high-quality research being conducted prior to the Olympics. Thanks to @Mathil_Poignard and everyone that made it such a great experience @iHealthSportVU

[Nick Saner @NickSaner]

@BakerResearchAu @erin_howden @Mark_Butler_MP Congrats Erin! 🎉

[Osvaldo Contreras @osvaldoics]

How fat hidden inside our muscles is ‘critical’ to health outcomes
https://t.co/zba2BDVJB7

Over the moon 😃 to read our recent multi-continent manuscript being highlighted in the Sydney Morning Herald @smh @theage by @sarzberry! 🗞️

Thanks @DavidScottPhD for your expertise and support.

Big kudos to Julia Timms!

@flowersmarcelo @KopinkeLab @F_Helmbacher @GordonSLynch

[Matt Lee @matt_lee1]

Access our latest review on delineating aging & physical activity-related changes in mitochondrial characteristics:
🔗https://t.co/m1j4Z5VCJu

This was a great collaborative effort with @NickSaner Alessandra Ferri @Esther_GD_ @JamesRBroatch @BlueSpotScience

[Nick Saner @NickSaner]

@LizReisman @JohnAHawley @NolanJHoffman @SpringerNature @SportsMedicineJ Nice work Liz!

[Craig A. Goodman @CraigAGoodman1]

Age-related changes in human skeletal muscle transcriptome and proteome are more affected by chronic inflammation and physical inactivity than primary aging
https://t.co/oupchrvOoL

[The Conversation - Australia + New Zealand @ConversationEDU]

Night matches at the Australian Open are a great spectacle 🎾 but sleep disruption is likely to wreak havoc even on professional athletes, writes @NickSaner (@victoriauninews) + @LivKnowles1 (@Deakin).

https://t.co/iARuRUhREX

[Matt Lee @matt_lee1]

🚨📰Very proud to see this work published! Huge thanks to the participants, my coauthors and collaborators, and all involved in this along the way.
https://t.co/x1Nabb16Ci
@JonBartlett66 @BlueSpotScience @mackinprof @NickSaner @bluebirdi @saraoikawa @tjstokes5 @MACleod_JC

[Emmanuel (Manos) Stamatakis @M_Stamatakis]

BIG day for @ProPASSconsort, 1st study out in Eur Heart J , modelling replacement FX of #PhysicalActivity/#Sleep/sitting/standing on cardiometabolic risk. Replacing [anything] with 4-5 mins of MVPA ➡️ gr8 promise. 🙏👋 to amazing #EMCRs @blodgettjm @Matthew_Ahmadi_ @AJAtkin

[Sleep Research Society @ResearchSleep]

As little as 1 percent reduction in deep #sleep per year for people over 60 years of age translates into a 27 percent increased risk of #dementia, according to a study published today in JAMA Neurology. https://t.co/zEFNfxwZ2p