Clinical Lecturer & Neurology doctor @UCLIoN @UCLH @AdrianIsaacsLab @PataniLab, using stem cells to study motor neuron disease & dementia. Funding: @acmedsci
Take a look at our recent Lancet Neurology review. Amyotrophic lateral sclerosis caused by TARDBP mutations: https://t.co/yXkRg4ePPe
It’s been a huge privilege working with this incredible writing team and we hope you enjoy reading it.
⭐️🤩🤓🤩⭐️
Out @ScienceMagazine! New tech to activate ALS gene therapies only in the right cells at the right time - Increased safety to have more options for ALS.
We do it by taking advantage of cryptic splicing.
https://t.co/tPNurQJREV
@UCLIoN@TheCrick@OscarWilkins16@MaxZYJChien
Our paper on cryptic splicing-controlled protein expression, which we hope will inspire safer and more adventurous gene therapy approaches for ALS and FTD, has been published in @ScienceMagazine https://t.co/YriG3I4ILF
Glad to see our review on the use of omics to study glia in ALS led by the superb Stan Majewski (not on X/Twitter) out in @GLIA_Journal!
@PataniLab@TheCrick@UCLIoN
https://t.co/Zdff9p0m26
Delighted to share our work, out today in @MDJ_Journal ! We highlight alpha-synuclein SAA positivity in PSP and CBS patient CSF samples. This may represent Lewy body co-pathology which can impact on clinical course (1/2)
@PSPAssociation@MDC_IoN_UCL
https://t.co/6hqrKSRI3w
“I am committed to finding effective treatments for MND and FTD.”
@RubikaBalendra won the 2024 #ENCALS Young Investigator award earlier this year, and chats about her #MND#ALS#FTD research in our latest blog post.
Read more ⬇️
https://t.co/grtZotnhYQ
Delighted that this has been published! I am very grateful to my co-author, faculty advisors, series editor and Elsevier. @Documiev @ElsevierConnect https://t.co/iUStGOI7Iw
Our open access opinion in @Brain1878 on the disappointing C9 ASO trials and next steps to deliver an effective treatment for C9ALS/FTD co-written with @AlexCammack @RubikaBalendra@UKDRI@UCLIoN https://t.co/A4kgL7j5bA
I am incredibly grateful and honoured to be the recipient of the ENCALS Young Investigator Award alongside the brilliant @ratkorad. I greatly appreciate the pwALS, supervisors, colleagues, collaborators and funders who have supported my research. @ENCALS https://t.co/UZSpPclOea
#ENCALS2024 closed. Tack Sweden! Massive honour being recognised alongside an amazing young investigator @RubikaBalendra. Thanks to everyone (pwALS, families, collaborator, healthcare professionals, funders etc.) for supporting our research @UEAResearch@EuansCentre@MNDScotland
Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by @AshlingGiblin and @AlexCammack https://t.co/NIm2FmGZV5 1/9
C9orf72 poly(PR) binds to 558 RNAs in human cells and the sequence GAAGA is enriched at its binding sites. Poly(PR) has nanomolar affinity for GAAGA RNA and this RNA induces poly(PR) phase separation. @Isaacs_Adrian@RubikaBalendra
https://t.co/IhLMhhfqMZ
Beaten to tweeting our paper by @ShorterLab! Check out the RNAs that bind C9orf72 polyPR -we hope a useful resource for the field @LSAjournal https://t.co/YDt8OT70a7