Delighted to share that our manuscript describing the structural dynamics of SAMHD1 catalysis using time-resolved cryoEM and extensive biophysics is now available online. Fantastic collaboration between several labs and STPs @TheCrick https://t.co/0XPGBrXjpl
'Building' up to the Holiday Season - Day 15.
Protein Structure Determination at Peak Proteins (part of Sygnature Discovery).
This structure is ATP synthase which catalyses the formation of the energy storage molecule adenosine triphosphate (ATP).
Excited to share our recent work on bacterial DNA replication initiation published in @NatureComms. Great collaborative effort with @heathmurraylab key contribution from @YardimciLab. Good team work overall @simopelliciari@Ch_Winterhalter Salome and Yumi
https://t.co/MZAV5e1wSA
'Building' up to the Holiday Season - Day 6.
Protein Expression and Purification at Peak Proteins (part of @SygnatureDiscov ). At Peak Proteins we can express and purify proteins from E. coli, insect and mammalian cells.
https://t.co/7zXDup6uRD
A Crick team including @ghostpathogen@MuraliMaradana@SaterialeLab and Gitta Stockinger have found that high levels of a molecule commonly found in cruciferous vegetables like broccoli could offer protection against the Cryptosporidium parasite 🥦🛡️🪱
https://t.co/HvWliTC8el
'Building' up to the Holiday Season - Day 4.
At Peak Proteins we use the Fida 1 platform from @FIDATechnology for a number of our client projects.
📖Read more about how we use Fidabio
https://t.co/REuoub4CsF
'Building' up to the Holiday Season - Day 2.
Day 2 - Horseshoe Crabs and Endotoxins!
At Peak Proteins (part of @SygnatureDiscov), we are experienced in minimising endotoxin levels where required by our clients for assays. Read to learn more !
https://t.co/TRohP4tOmF
'Building' up to the Holiday Season - Day 1.
We're counting down to the holidays with a series of models highlighting what we do at Peak Proteins (part of @SygnatureDiscov ).
First up is our bioreactor @InforsUK - read more https://t.co/2Iffd5RdYk
Agar Plate Art!
Recently Peak Proteins' scientists got creative and designed and produced bacterial art for entrance into the @ASMicrobiology 's “Microbiology in Space" Agar Art Contest.
🚀🦠🎨
https://t.co/xPM1lkJ5HY
If you are interested in using #CryoEM and #Chemistry to study PROTACs for cancer treatment do a iCASE #PhD with James Hodgkinson, John Schwabe and me @LeicStructBio and @PeakProteins. Click here and scroll to the bottom ⬇️🔬https://t.co/71PualEHGt
Thrilled to share this review with @LMSpenkelink & @van_Oijen on the advancements in single-molecule approaches & cryo-EM🔬. These technologies are reshaping our understanding of DNA replication dynamics! #StructuralBiology#Biophysics#AcademicChatter https://t.co/BJiaC7NSmk
Our study on the cover of Molecular Cell 🥳. Thanks @AgaGambus and @GS_Lab_Bham for a great collaboration.
Structure by Milos Cvetkovic❄️, @PaoloPassaretti🧬, Agata Butryn👩🔬.
Artwork by @petermindek and the https://t.co/M6Q6EjdoVc team.
Our latest paper uses structural biology, biochemistry & biophysics to reveal the two-step catalytic mechanism of the human nucleotide pool sanitiser DNPH1. This will aid the development of novel inhibitors, which may be of use in breast cancer treatment. https://t.co/ktJJ8Enj9g