Shrika Eddula

FDE, Life Sciences @OpenAI
Prev CS @MIT @Broad

[Vladimir Aladinskiy @VladAladin]

GPT-6 Astra is the best frontier model for multi-step retrosynthesis. 🧪

In our DDD Benchmark, it outperformed every other frontier model we tested, coming remarkably close to specialist-level models for synthesis planning.

Our Rentosertib molecule, which showed an age-reversing effect across 6 aging clocks in Phase 2 clinical trials, also had to be synthesized somehow. 😅

And that’s exactly what we measure here: how well a model can predict synthetic routes for small molecules.
Great job @sama, @gdb 👏
#insilicoSOTAFM

[Shrika Eddula @ShrikaEddula]

@ChrisHayduk This is so goated

[Chris Hayduk @ChrisHayduk]

The Rosalind Workbench has been out for a week now - show me the coolest thing you've built with it!

Coolest project gets 1 free year of ChatGPT Pro!

Either comment here or quote tweet me to submit. Provide screenshots and the Rosalind plugins you used to make it happen!

[Shrika Eddula @ShrikaEddula]

@evatuecke @payathepapaya @altaratech @catherinehyeo Why hello 🐐

[Erik Reinertsen, MD, PhD @erikrtn]

Healthcare organizations can now connect EHR and additional industry data to ChatGPT https://t.co/9wclIspxYe

[Shrika Eddula @ShrikaEddula]

Huge congratulations to everyone who brought this to life, give it a spin :)

[Chris Hayduk @ChrisHayduk]

At OpenAI, it's felt like our researchers & engineers have been living in the future with Codex.

Today, we're bringing that same experience to life science researchers with the Rosalind Workbench.

[Chris Hayduk @ChrisHayduk]

At OpenAI, it's felt like our researchers & engineers have been living in the future with Codex.

Today, we're bringing that same experience to life science researchers with the Rosalind Workbench.

[Shrika Eddula @ShrikaEddula]

@conconconling Whimsy-maxxing

[Shaamil @ShaamilKarim1]

There are a lot of potentially life-saving treatments hiding in plain sight, so we built a harness to coordinate a fleet of agents and hundreds of biomedical tools to find them!

[Shrika Eddula @ShrikaEddula]

@ShaamilKarim1 @ycombinator Huge congrats, incredibly excited!! Also omg the background 👀

[Shrika Eddula @ShrikaEddula]

@tararezaeikh @MirendilAI You inspire me everyday, congrats Tara <33

[Tara Rezaei @tararezaeikh]

Today, we are formally announcing @mirendil. Mirendil exists to be a straight shot at solving bottlenecks to step-change acceleration across all areas of science and technology. If you are excited about this mission, feel free to reach out.

[Behnam Neyshabur @bneyshabur]

Today, I’m excited to formally announce @mirendil with my amazing co-founders Harsh Mehta, Shayan Salehian, and Tara Rezaei!

We’re fortunate to work with @a16z and @kleinerperkins, who led our seed round of $200M, followed by a major investment from NVIDIA, among others.

Mirendil exists to accelerate science and technology, and through them, to help solve humanity's most pressing problems.

Self-accelerating AI R&D is the most direct path to delivering on AI's broader promise, which is why we believe the most important application of AI is AI itself. Get this loop right, and it compounds. It fundamentally changes the rate of progress itself across all domains.

We believe this capability should be democratized. It should be used to power all scientific efforts trying to innovate at the frontier. There are far more important problems—and broader ones—than any single lab can take on, so more groups should be able to pursue them.

This pulls concentration of power away from a few labs: businesses and science labs can own their AI and infrastructure, keep their margins, and control their own destiny instead of ceding it all to a single AI lab.

We’re a small team with a singular focus. Our founding team consists of 20 researchers and engineers from frontier institutions including Anthropic, xAI, Google DeepMind, and OpenAI, united by a passion for science and a drive to build the technologies that move it faster. If you want to build the system that builds systems, join us!

@HarshMeh1a, @shayan_, @tararezaeikh

[Shrika Eddula @ShrikaEddula]

@ty_todd1 @modaicdev @a16z @speedrun yay congrats ty!!

[Catherine Yeo @catherinehyeo]

At the recent @OpenAIDevs Founder Day, I had fun chatting about how we use OpenAI's capabilities to scale scientific intelligence at @altaratech:
- Helping scientists and engineers reason across complex, multimodal data
- Parallelizing long-running workflows
- Building trust through greater transparency

If you're interested in tackling challenges in AI for science, we're hiring! (Link below)

[Shrika Eddula @ShrikaEddula]

@catherinehyeo @evatuecke @GreylockVC @neo @BoxGroup @Liquid2V @JeffDean My favorite people doing my favorite thing, congrats yall!

[Catherine Yeo @catherinehyeo]

Introducing Altara: the scientific intelligence platform for the physical world.

Today @evatuecke and I are excited to announce our $7M seed led by @GreylockVC, joined by @Neo, @BoxGroup, @Liquid2V, and angel investors including @JeffDean and leadership from OpenAI & AMD.

We’re already working with early customers in semiconductors, batteries, and advanced materials. More below.

[Shrika Eddula @ShrikaEddula]

@annarmonaco @paradigmai Omg exciting stuff, congrats :)

[Anna Monaco @annarmonaco]

Today we’re launching the newest version of @paradigmai

When we started Paradigm, the goal was never to tack AI onto existing spreadsheets. It was to build a new type of interface that does the work for you.

Now we’re pushing that vision much further.

Workflows turn Paradigm into a system that runs research processes for you.

Connect your CRM, existing spreadsheets, Slack, email, and internal data, and let Paradigm continuously run the research workflows your team already does.

Same intuitive interface. But now a system of action.

If you tried Paradigm before, try it again.

Manual research is now a competitive liability.

[Leonie Freisinger @lcfreisi]

My cofounder @AnnaJuliaStorch and I grew up in manufacturing towns while spending our days chasing speed - on the mountains and the racetrack. With @DryftHQ , we bring our love for both worlds to life.

That’s why we couldn’t be more excited to finally come out of stealth and announce our $5M round led by @GeneralCatalyst, with participation from @Neo, @SherylSandberg ’s Fund, @JeffAWilke, @CHughesJohnson, Dr. Markus Flik, @Qasar and many other incredible Angels. (see below)