Pedro Cunha

Iminente personalidade da sociedade civil

[Pedro Cunha @pedrocunha37]

It’s finally out 🎉! Our study on how low oxygen levels sensed by CD8+ T cells during activation modulate T cell function and can be harnessed to improve immunotherapeutic efficacy @eLife https://t.co/K1GFED3pig. Here's the tweetorial ⬇️⬇️⬇️(1/n)

[Aziz Sunderji @AzizSunderji]

As a new parent, I spend a lot of time changing diapers and feeding the baby. 15 months ago I wasn't doing any of this. I felt busy then too, so where did all this childcare time come from? I analyzed the Census Bureau's American Time Use Survey to find out how most parents do it. The answer: less sleep and less screen time. The funny thing is, parents report being pretty happy about this tradeoff.

[Samuel Hume @DrSamuelBHume]

What's the coolest science paper of 2025 so far?

[Pereira Lab @CellReproLab]

📢 New in @ImmunityCP: We have mapped the transcription factor “routes” that program two dendritic cell subsets opening paths for personalized #cancer #immunotherapy.
Read it here: https://t.co/u4j9xoVhEL
Here is a summary of what we discovered 🧵: 
Illustration by @azuravesta

[Pedro Cunha @pedrocunha37]

@Pubide1 @desarme_tatico Vai para lá tu fazer melhor ó Anti!

[Pereira Lab @CellReproLab]

1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in @ScienceMagazine.
https://t.co/yPDqKmpGnn
Here is a summary of what we discovered!

[Colin Lee @ColinYCLee]

Interested in tumour immunity, dendritic cells and immunotherapy? Excited to share our study on CCR7+ dendritic cells (DCs) in cancer out today, a joint effort between @LabWithers and @ClatworthyLab. (🧵 1/8)

https://t.co/DspJiAl5vf

[Rony Dahan @DahanLab]

Together with @IdoAmitLab we’re very excited to introduce BiCE (Bispecific DC-T Cell Engager)- a new platform to engineer immune cell communication for #cancer #immunotherapy. Led by the amazing @yuval_shap @orenbarboy, now out @CellCellPress: https://t.co/COVWAN7Tbf
(1/11)

[Julia Bauman @JuliaBauman2]

Here’s the short form teaser:

[Jacob Schreiber @jmschreiber91]

It's been since my last pitfall in genomics thread but he's a new one: YOU MUST ACCOUNT FOR READ DEPTH in single-cell experiments.

Why?

Because read depth will likely be confounded by CELL IDENTITY in ways that can induce leakage in downstream ML methods.

[Christina Agapakis @thisischristina]

Shoutout to this magical device that heats up mosquito bites really hot and denatures the proteins that make them itchy

[Xavier Lab @TheXavierLab]

Online @ImmunityCP! @mstrazar07 & colleagues identify HLA-II binding peptides w/monoallelic #immunopeptiomics & develop a #machinelearning tool (CAPTAn) that predicts peptide antigens based on HLA-II affinity and source protein sequence.
https://t.co/cV0dzS82dj

[Judy Minkoff, PhD @JudyMinkoff]

Summary of a really cool paper in @Nature by Rojas et al. mRNA vaccine targeting #PancreaticCancer neoantigens in combination w/ immune checkpoint inhibitor appears to generate CD8 T cells capable of eliminating tumor cells. Promising results!!
https://t.co/B8nyGX0DGJ

[ACIR @ACIR_org]

To understand how T cells disengage from targets to allow serial killing, @stinchcombejane @griffiths_lab used peroxidase labeling of CD3ε and advanced imaging to follow TCR fates during interactions with target cells. https://t.co/7zvQVrhgMk

[Nature Communications @NatureComms]

Microscopy-based phenotypic profiling of infection by Staphylococcus aureus reveals intracellular lifestyle as a prevalent feature of clinical isolates

@UnivdeCoimbra @cnc_uc @CIRI_Lyon @lopesrra
#Microbiology #Staph

https://t.co/aUZSW3Easc

[Pedro Cunha @pedrocunha37]

BONUS TRACKS: (2/2) To depict the role of HIF in our study, we designed a CAR vector with a domain to silence the negative HIF regulator VHL which showed promising in vivo results. shVHL-CAR T cells can clonally expand in vivo and fuel the functional benefits of hypoxic T cells.

[Pedro Cunha @pedrocunha37]

It’s finally out 🎉! Our study on how low oxygen levels sensed by CD8+ T cells during activation modulate T cell function and can be harnessed to improve immunotherapeutic efficacy @eLife https://t.co/K1GFED3pig. Here's the tweetorial ⬇️⬇️⬇️(1/n)

[Pedro Cunha @pedrocunha37]

BONUS TRACKS: (1/2) We show that the low O2-driven T cell alterations include HIF-dependent and independent mechanisms (e.g. PGC-1a expression), as assessed with the use of the PHD chemical inhibitor FG-4592 and silencing of VHL.